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Human antibodies derived from immunized xenomice

  • US 6,150,584 A
  • Filed: 10/02/1996
  • Issued: 11/21/2000
  • Est. Priority Date: 01/12/1990
  • Status: Expired due to Fees
First Claim
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1. A transgenic mouse wherein all of the somatic and germ cells comprise a DNA fragment of human chromosome 14 from the five most proximal VH gene segments, continuing through the D segment genes, the J segment genes and the constant region genes through Cδ

  • of the human immunoglobulin heavy chain locus, wherein said fragment does not contain a Cγ

    gene, and wherein said fragment is operably linked to a human Cγ

    2 region gene;

    said transgenic mouse producing fully human IgG2 heavy chains specific for a desired antigen when immunized with said desired antigen.

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