Instrument for measuring concentrations of constituent parts of blood

• US 6,151,518 A
• Filed: 03/03/1999
• Issued: 11/21/2000
• Est. Priority Date: 03/03/1998
• Status: Expired due to Fees

• Current Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Original Assignee: Fuji Photo Film Co Limited (Fujifilm Holdings Corporation)
• Inventors: Hayashi, Katsumi
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/261,214
• Time in Patent Office: 629 Days
• Field of Search: 600/310, 600/322, 600/323, 600/326, 600/330
• US Class Current: 600/322
• CPC Class Codes: A61B 5/14551 for measuring blood gases

Abstract

A blood-constituent concentration measuring instrument capable of accurately measuring concentrations of the constituent parts of blood without invading tissue. Light source means (1) emits measuring light (S) to a living organism (2). The measuring light (S) consists of a plurality of wavelength components different from one another. Straight-advance light discrimination means (3) extracts a straight-advance light component or a scattered light component close thereto from light scattered at the living organism (2). Then, extinction-index change detection means (4) detects an extinction index change in straight-advance light component or the scattered light component extracted by the straight-advance light discrimination means (4). Calculation means (5) calculates concentrations of the constituent parts of the blood, based on the extinction index change for each wavelength component of the measuring light.

Claims

1. A blood-constituent concentration measuring instrument comprising:

light source means for emitting measuring light to a portion of a living organism including a blood vessel, the measuring light having a plurality of wavelength components different from one another;

straight-advance light discrimination means for extracting a straight-advance light component or a scattered light component traveling along nearly a same optical path as said straight-advance light component from said measuring light which has passed through said living organism;

extinction-index change detection means for detecting an extinction index change in said straight-advance light component or said scattered light component extracted by said straight-advance light discrimination means; and

calculation means for calculating concentrations of the constituent parts of the blood, based on said extinction index change for each wavelength component of said measuring light.

2. The blood-constituent concentration measuring instrument as set forth in claim 1, wherein said light source means emits measuring light which has a plurality of wavelength components corresponding in number to variables to be measured, the variables corresponding to the constituent parts of blood to be measured.

3. The blood-constituent concentration measuring instrument as set forth in claim 2, wherein said straight-advance light discrimination means is constructed of an optical heterodyne interferometer that generates a beat signal representing only said straight-advance light component or said scattered light component.

4. The blood-constituent concentration measuring instrument as set forth in claim 2, wherein said straight-advance light discrimination means is constructed of a streak camera that detects said straight-advance light component or said scattered light component in such a manner that it is discriminated on a time axis from a scattered light component incident at a later time than said straight-advance light component or said scattered light component.

5. The blood-constituent concentration measuring instrument as set forth in claim 2, wherein, when said variables include n variables, said calculation means solves n simultaneous Lambert-Beer equations to calculate the concentrations of said constituent parts of blood.

6. The blood-constituent concentration measuring instrument as set forth in claim 2, wherein said variables include a hematocrit value and said calculation means performs said calculation.

7. The blood-constituent concentration measuring instrument as set forth in claim 1, wherein said straight-advance light discrimination means is constructed of an optical heterodyne interferometer that generates a beat signal representing only said straight-advance light component or said scattered light component.

8. The blood-constituent concentration measuring instrument as set forth in claim 1, wherein said straight-advance light discrimination means is constructed of a streak camera that detects said straight-advance light component or said scattered light component in such a manner that it is discriminated on a time axis from a scattered light component incident at a later time than said straight-advance light component or said scattered light component.

9. The blood-constituent concentration measuring instrument as set forth in any one of claims 1 through 4, wherein said extinction-index change detection means detects said extinction index change caused by pulsation of an artery of said living organism.

10. The blood-constituent concentration measuring instrument as set forth in claim 1, wherein said extinction-index change detection means calculates a difference between the maximum and minimum values of a signal that was obtained by detecting said straight-advance light component or said scattered light component, thereby detecting said extinction index change caused by pulsation of an artery of said living organism.

11. A method of measuring blood-constituent concentrations comprising steps of:

irradiating measuring light onto a portion of a living organism including a blood vessel, the measuring light having a plurality of wavelength components different from one another;

extracting a straight-advance light component or a scattered light component traveling along nearly a same optical path as said straight-advance light component from said measuring light which has passed through said living organism;

detecting an extinction index change in said straight-advance light component or said scattered light component extracted in said extracting step; and

calculating the concentrations of the constituent parts of the blood, based on said extinction index change for each wavelength component of said measuring light.