Apparatus and procedure for measuring volumes and global and segmental corporal composition in human beings

• US 6,151,523 A
• Filed: 03/04/1998
• Issued: 11/21/2000
• Est. Priority Date: 03/06/1997
• Status: Expired due to Fees

• Current Assignee: NTE-Sener SA
• Original Assignee: NTE Incorporated
• Inventors: Pallas Areny, Ramon, Riu Costa, Pere, Elvira Canas, Jordi, Bragos Bardia, Ramon, Rosell Ferrer, Javier
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): MANTIS MERCADER, ELENI M
• Application Number:
  US09/034,223
• Time in Patent Office: 993 Days
• Field of Search: 600/506, 600/546, 600/547, 600/507
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: A61B 5/4872 Body fat

Abstract

Apparatus and procedure for measuring volumes and global and segmental corporal composition in human beings, by means of measuring the electrical impedance at various frequencies, determining in this manner, the ratio between the intracellular water and the extracellular water volumes, the contents of total and extracellular water in each segment and the contents of the segmental lean mass. The apparatus is made up of a computer (11) which controls an electronic box (12), fed through a feeding source (14), various electrodes (13) coming out from said electronic box (12) which are placed on the body under research.

Claims

1. A method for measuring volumes and global and segmental corporal composition in human beings comprising:

measuring the electrical impedance at a plurality of locations corresponding to a plurality of predeteremined segments of a human body, using a minimum of four frequencies in the range of 1 kHz to 1 MHz,

estimating the ratio between the total water and extracellular water volumes, both at global and segmental levels, by determining the k quotient between the impedance module at low frequency Z(BF), placed between 1 kHz and 50 kHz, and the impedance module at high frequency Z(AF), placed between 100 kHz to 10 MHz, said quotient being independent from the conditions of the measurement contour,

adjusting said quotient by the least squares method, both at global and segmental levels, by the following electrical impedance expression (Z) based on the frequency (f);

##EQU20## thus determining the values R.sub.∞

, R₀, f_c and α

, wherein R₂₈ represents the resistance at infinite frequency, R₀ represents the resistance at zero frequency, f_c represents the frequency at which the maximum of lm(Z) occurs and α

represents the dispersion of the cells of the biological system, with which the following values are calculated;

a) the ratio between the intracellular water and extracellular water volumes, given by;

##EQU21## b) the total water content of a segment i (TBW_seg,i), given by;

##EQU22## and the content of a segment i in extracellular water (ECW_seg,i) which is determined by;

##EQU23## wherein H is the height of the body in cm, K_TBW is a constant of proportionality for the total water (TBW), K_ECW is a constant of proportionality for the extracellular water, Ko_TBWseg,i is the independent term for segment i, Ko_ECWseg,i, is the independent term for the extracellular water (ECW) for segment i, and L'"'"'_seg,i and L'"'"'_seg,i are geometric terms to be determined for each segment I, wherein the real value (Z(∞

)) corresponds to the real value of an impedance over 100 kHz and below 1 MHz for segment i, but preferably at R∞

, and the real value (Z(10 kHz)) corresponds to the real value of an impedance over 10 kHz and below 50 kHz for segment i, but preferably at R₀ ;

c) the content of segment i in the intracellular water which is determined by means of the subtraction of ECW_seg,i from TBW_seg,i ;

d) the volume of total and extracellular water at the global level which shall be determined by the sum of the respective values of segments i;

e) the content of the segmental or regional MM_seg,i and global lean mass by means of the equation ##EQU24## N and M being terms which are introduced from the lineal regression between the ratio;

##EQU25## and the value of the amount of lean mass measured by means of an alternative method and which depend on the type of human race, and D²_eq,seg,i, a geometric parameter of segment i; and

obtaining the global value of the amount of lean mass from the sum of all the values MM_seg,i and the global fatty mass from the difference between the weight of the human body studied and the weight of the amount of global lean matter.

2. A method according the claim 1, comprising determining the volume of total and extracellular water at the global level using an RSI (right side impedance) as if it was a segment conveniently considering the specific parameters of the TBW and ECW formulas.

3. An apparatus for measuring the electrical impedance for the method of claim 1 comprising a backplane which interconnects an electrical source and four signal generator boards, wherein a first signal generator board generates at least two of said frequencies as well as reference signals for demodulation, a second board for patient interface converts the tension signals generated into current, a third detection signal board is made up of a differential amplifier and a gain amplifier with selectable gains via software and a fourth A/D obtention board is provided with an A/D converter for sampling for data obtention, wherein said electrical source is adapted to be connected to the human body under study by means of a multiplexor which permits any pair of electrodes to be connected to the said source, by connecting each one of the electrodes to an input buffer, whilst each one of their outputs is connected to a multiplexor circuit which feeds a differential amplifier, and wherein the control of the system is conducted by means of a microcontroller.

4. Apparatus according to claim 3, further comprising an accelerometer which measures acceleration to which the body has been subjected, in a synchronized manner with the impedance measure.

5. A process for measuring the volume and global and segmental corporal compositions in human beings, comprising:

measuring the electrical impedance at a plurality of locations corresponding to a plurality of predetermined segments of a human body, using various frequencies within the range between 1 kHz and 1 MHz;

estimating the ratio between total water and extracellular water volumes, both at global and segmental levels;

adjusting the estimated ratio at both global and segmental levels using the least squares method, wherein preselected parameters can be used to determine the ratio between intracellular and extracellular water volumes, the total water content of one or more predetermined segments, the intracellular water content of said one or more predetermined segments, and the volume of total and extracellular water at the global level, by adding and/or substracting the values associated with said predetermined segments.

6. The process of claim 5, wherein said parameters are used to determine the ratio, at both global and segmental levels, of lean mass to fatty mass within said human being.