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Method for non-invasive blood analyte measurement with improved optical interface

  • US 6,152,876 A
  • Filed: 10/19/1998
  • Issued: 11/28/2000
  • Est. Priority Date: 04/18/1997
  • Status: Expired due to Term
First Claim
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1. A non-invasive method for measuring the concentration of blood analyte in human tissue comprising the steps of:

  • providing an apparatus for measuring infrared absorption, said apparatus including an energy source emitting infrared energy at multiple wavelengths, including selected wavelengths relevant to analyte concentration due to absorption by said analyte, operatively connected to an input element, said apparatus further including an output element operatively connected to a spectrum analyzer;

    providing an index-matching medium, said index-matching medium having minimal absorption of infrared energy at said selected wavelengths and a refractive index of between about 1.30 and 1.45, and disposing a quantity of said medium between said human tissue and said input element and output element to couple said elements to said analyte-containing tissue through said index-matching medium; and

    ,irradiating said tissue through said input element with said multiple wavelengths of infrared energy so that there is differential absorption of at least some of said wavelengths; and

    ,collecting at least a portion of the non-absorbed infrared energy with said output element for analysis of absorption with subsequent calculation of blood analyte concentration utilizing an algorithm and a model.

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