Method and apparatus to measure blood flow rate in hemodialysis shunts

• US 6,153,109 A
• Filed: 01/22/1998
• Issued: 11/28/2000
• Est. Priority Date: 09/16/1994
• Status: Expired due to Fees

• Current Assignee: Transonic Systems, Inc. (Measurement Innovations Corp.)
• Original Assignee: Transonic Systems, Inc. (Measurement Innovations Corp.)
• Inventors: Krivitski, Nikolai
• Primary Examiner(s): KIM, SUN U
• Application Number:
  US09/010,697
• Time in Patent Office: 1,041 Days
• Field of Search: 210/645, 210/646, 210/739, 210/745, 210/746, 210/805, 210/85, 210/93, 210/96.1, 210/96.2, 210/97, 210/103, 210/321.6, 210/929, 73/861.05, 73/861.06, 73/861.18, 73/861.25, 73/861.27, 73/861.07, 73/861, 604/4, 604/5, 604/65, 604/67, 604/4.01, 604/5.01, 436/56, 436/164
• US Class Current: 210/739
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/3623 Means for actively controlling temperature of blood
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3655 Arterio-venous shunts or fistulae
• CPC Class Codes: A61M 1/3656 Monitoring patency or flow at connection sites; Detecting disconnections
• CPC Class Codes: A61M 1/3658 Indicating the amount of purified blood recirculating in the fistula or shunt
• CPC Class Codes: A61M 1/3663 Flow rate transducers; Flow integrators
• CPC Class Codes: A61M 1/3669 Electrical impedance measurement of body fluids; transducers specially adapted therefor
• CPC Class Codes: A61M 1/367 Circuit parts not covered by the preceding subgroups of group A61M1/3621

Abstract

A device for determining shunt flow in a hemodialysis shunt connected between two points in a cardiovascular-hemodialysis system includes a flow sensor connected to either the hemodialysis inflow (arterial) line or the outflow (venous) line. An indicator is preferably introduced into the system that is sensed by first and second sensors that are spaced apart and disposed effective for sensing the indicator at two locations in the cardiovascular-hemodialysis system. Natural indicators produced by the body, such as density variations in the blood caused by rhythmic breathing, are optionally used instead of an introduced indicator. A detector connected to the flow sensor and the first and second sensors determines, at a first flow rate, a first time a first indicator takes to move between the two locations, and at a second flow rate, a second time a second indicator takes to move between the two locations. The shunt flow is then calculated from the first and second times and the first and second flow rates.

Claims

1. A method for determining shunt flow in a shunt connected between first and second points in a circulating system, comprising the steps of:

a) establishing a first flow rate in said circulating system;

b) measuring, during said first flow rate, a first line velocity in the shunt between a first point in the shunt and a second point in the shunt;

c) establishing a second flow rate in said circulating system;

d) measuring, during said second flow rate, a second line velocity in the shunt between the first point in the shunt and the second point in the shunt; and

e) calculating said shunt flow from said first line velocity and second line velocity and said first and second flow rates.

2. A method according to claim 1, wherein said second flow rate is zero.

3. A method according to claim 1, wherein:

said circulating system is a hemodialysis system which includes a cardiovascular portion and a hemodialysis portion; and

said shunt is a hemodialysis shunt.

4. A method according to claim 3, wherein both steps of establishing are within said hemodialysis portion of said hemodialysis system.

5. A method according to claim 3, wherein both steps of measuring include detecting a change of a blood property.

6. The method of claim 1, in which step (b) of measuring the first line velocity and step (d) of measuring second line velocity comprise measuring a time at least one indicator takes to move between a first location and a second location, and calculating the line velocity from the measured time.

7. A method according to claim 6, wherein said at least one indicator includes first and second indicators.

8. A method according to claim 7, further comprising:

introducing, before the step of measuring during said first flow rate, said first indicator into said circulating system; and

introducing, before the step of measuring during said second flow rate, said second indicator into said circulating system.

9. A method according to claim 6, wherein said first and second locations are at said first and second points, respectively.

10. The method of claim 6, wherein said first and second locations are between said first and second points.

11. A device for determining shunt flow in a shunt connected between first and second points in a circulating system, comprising:

means for establishing a flow rate in said circulating system;

means for measuring a line velocity in the shunt;

such that when the means for establishing a flow rate is operated at a first flow rate, the means for measuring a line velocity measures a first line velocity in the shunt; and

when the means for establishing a flow rate is operated at a second flow rate, the means for measuring a line velocity measures a second line velocity in the shunt;

means for calculating said shunt flow from said first line velocity and second line velocity and said first and second flow rates.

12. The device of claim 11, in which the means for measuring the line velocity comprises means for measuring a time at least one indicator takes to move between a first location and a second location in the shunt, and means for calculating the line velocity from the measured time.

13. A device according to claim 12, further comprising means for introducing first indicator and second indicator in said circulating system.

14. A device according to claim 13, wherein:

said circulating system is a hemodialysis system which includes a cardiovascular portion and a hemodialysis portion;

said shunt is a hemodialysis shunt; and

said means for introducing are within said hemodialysis portion of said hemodialysis system.

15. The device of claim 12, in which the means for measuring the time at least one indicator takes to move between a first location and a second location comprises first and second sensors spaced apart and disposed effective for sensing an indicator at first and second locations in said circulating system.

16. A device according to claim 15, further comprising at least one indicator introduction location in said circulating system.

17. A device according to claim 16, wherein:

said circulating system is a hemodialysis system which includes a cardiovascular portion and a hemodialysis portion;

said shunt is a hemodialysis shunt; and

said at least one indicator introduction location is within said hemodialysis portion of said hemodialysis system.

18. A device according to claim 15, wherein said first and second locations are at said first and second points, respectively.

19. A device according to claim 15, further comprising:

third and fourth sensors;

wherein

said third sensor is disposed on an opposite side of said shunt from said first sensor, and

said fourth sensor is disposed on an opposite side of said shunt from said second sensor.

20. A device according to claim 15, wherein means for measuring a flow rate includes a flow sensor connected to said circulating system.

21. A device according to claim 15, wherein said at least one indicator is only one indicator.

22. A device according to claim 15, wherein said at least one indicator consists of first and second indicators.

23. A device according to claim 12, wherein:

said at least one indicator includes first and second indicators.

24. A device according to claim 23, wherein said first and second locations are at said first and second points, respectively.

25. A device according to claim 23, wherein said first and second locations are between said first and second points.

26. A device according to claim 11, wherein one of said first flow rate and second flow rate is zero.

27. A device according to claim 11, wherein:

said circulating system is a hemodialysis system which includes a cardiovascular portion and a hemodialysis portion; and

said shunt is a hemodialysis shunt.

28. A device according to claim 27, wherein said means for measuring comprises means for detecting a change of a blood property.

29. A device according to claim 27, wherein said means for establishing a flow rate is within said hemodialysis portion of said hemodialysis system.