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Stabilized pharmaceutical compositions

  • US 6,153,223 A
  • Filed: 06/05/1998
  • Issued: 11/28/2000
  • Est. Priority Date: 06/05/1998
  • Status: Expired due to Term
First Claim
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1. A method for stabilizing a pharmaceutical composition which comprises the step of:

  • a) premixing a pharmaceutically acceptable carrier and an aqueous solution of an acid;

    b) drying the premixture from step a) to form an acidic pharmaceutically acceptable carrier; and

    c) admixing a stabilizing amount of the dried acidic pharmaceutically acceptable carrier from step b) with a pharmaceutical agent unstable at a pH above about 3.5 to form a stabilized pharmaceutical composition, whereinthe acidic pharmaceutically acceptable carrier provides an acidic stabilizing microenvironment around the pharmaceutical agent.

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