Controlled viscosity dermal adhesive

• US 6,155,265 A
• Filed: 06/24/1999
• Issued: 12/05/2000
• Est. Priority Date: 12/17/1997
• Status: Expired due to Term

• Current Assignee: Clast Trading Ltd.
• Original Assignee: Hemodynamics, Inc.
• Inventors: Hammerslag, Julius G.
• Primary Examiner(s): Nguyen, Dinh X.
• Application Number:
  US09/339,146
• Time in Patent Office: 530 Days
• Field of Search: 128/898, 128/897, 623/2, 623/11, 623/66, 602/42, 602/48, 602/41, 602/43, 602/54, 602/59
• US Class Current: 128/898
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/085 with adhesive layer
• CPC Class Codes: A61B 2017/0065 the implement being an adhesive
• CPC Class Codes: A61L 24/0089 containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084
• CPC Class Codes: C08L 35/04 Homopolymers or copolymers of nitriles C08L35/06, C08L35/08 take precedence

Abstract

Methods and compositions for closing and sealing a wound, laceration, incision, or other percutaneous opening using an adhesive. In one preferred embodiment, the sides of the percutaneous opening are brought together in apposition and the adhesive is applied to the opening and the skin immediately adjacent thereto. Adhesives used in the methods exhibit sufficient viscosity to substantially prevent flow of the adhesive into the percutaneous opening. In a preferred embodiment, the adhesive is a sealing medium comprising an adhesive component and a microparticulate component. Preferred sealing media comprise cyanoacrylates combined with fumed silica. In such embodiments, the fumed silica is present in an amount sufficient to substantially prevent the medium from flowing into the opening at normal skin temperature.

Claims

1. A method of closing a percutaneous opening, having a first dermal surface on a first side of the opening and a second dermal surface on a second side of the opening and generally coplanar with the first dermal surface, the method comprising the step of:

applying an adhesive layer across at least at portion of the first and second dermal surfaces and spanning the opening, wherein the adhesive exhibits a sufficient viscosity to substantially prevent flow of the adhesive into the opening.

2. A method as in claim 1, wherein the viscosity is within the range of from about 1000 to about 100,000 centipoise.

3. A method as in claim 2, wherein the viscosity is within the range of from about 40,000 to about 80,000 centipoise.

4. A method as in claim 1, wherein the viscosity is at least about 1,000 centipoise.

5. A method as in claim 4, wherein the adhesive comprises an adhesive component and a viscosity enhancing component.

6. A method as in claim 5, wherein the adhesive component comprises a nonbiological monomer.

7. A method as in claim 6, wherein the adhesive component comprises a cyanoacrylate.

8. A method as in claim 5, wherein the viscosity enhancing component comprises silica.

9. A method as in claim 1, wherein the adhesive layer has a thickness over the opening of at least 1 millimeter.

10. A method of closing and sealing a wound in a patient, comprising the steps of:

positioning opposing sides of a wound in an adjacent configuration; and

delivering a wound closure medium comprising an adhesive component and a viscosity enhancing component to the surface of the skin spanning said wound in a quantity sufficient to retain closure of said wound, said viscosity enhancing component being present in an amount sufficient to substantially prevent the medium from flowing into a gap of about 1 millimeter or less at normal skin temperature.

11. A method as in claim 10, further comprising a step of applying an aqueous solution to the wound prior to the delivering step.

12. A method as in claim 10, further comprising the step of permitting the medium to polymerize following the delivering step.

13. A method as in claim 11, wherein the medium has a prepolymerization viscosity of at least about 1000 centipoise.

14. A method of closing and sealing a wound in a patient, comprising the steps of:

identifying a percutaneous wound having first and second sides;

delivering a layer of wound closure media to the surface of skin on each of the first and second sides and across the wound in a quantity sufficient to retain closure and sealing of said wound; and

restraining media from entering the wound.

15. A method as in claim 14, wherein the restraining step comprises providing the wound closure media with a sufficient viscosity to extend in a layer across the wound, while substantially preventing the media from entering the wound.

16. A method as in claim 15, wherein the viscosity is at least 1000 centipoise.

17. A method as in claim 16, wherein the viscosity is at least about 40,000 centipoise.