Method for microencapsulating of a solid substance

• US 6,156,245 A
• Filed: 02/26/1999
• Issued: 12/05/2000
• Est. Priority Date: 03/05/1998
• Status: Expired due to Term

• Current Assignee: Sumitomo Chemical Company Limited
• Original Assignee: Sumitomo Chemical Company Limited
• Inventors: Takebayashi, Yoshihiro, Ueda, Nobuhito, Nishi, Shugo
• Primary Examiner(s): HAMPTON HIGHTOWER, PATRICIA
• Application Number:
  US09/257,951
• Time in Patent Office: 648 Days
• Field of Search: 428/402.21, 424/400, 424/405, 424/408, 264/4.7, 264/4.33
• US Class Current: 264/4.7
• CPC Class Codes: B01J 13/06 by phase separation
• CPC Class Codes: B01J 13/18 In situ polymerisation with all reactants being present in the same phase
• CPC Class Codes: Y10T 428/2985 Solid-walled microcapsule from synthetic polymer

Abstract

The present invention provides a microencapsulation method of a solid substance and the microencapsulated composition obtained from said method of: (i) preparing a dispersion phase comprising (a) a solution containing a substance which forms a middle layer and (b) a solid substance that is insoluble or difficult to dissolve in said solution, (ii) obtaining a solid substance which has a layer made of the substance which forms the middle layer by phase-separating the substance which forms the middle layer from the solution and (iii) reacting a monomer that is polymelizable by condensation in the presence of the solid substance that has a layer made of the substance which forms the middle layer.

The above method can efficiently microencapsulate pharmaceutical active ingredients, pesticidal ingredients, aroma active ingredient and so on that are solid substances and affords an efficacious microencapsulated composition of solid substances.

Claims

1. A microencapsulation method of a solid material comprising (i) preparing a dispersion phase comprising (a) a solution containing a substance which forms a middle layer and (1) a solid substance that is insoluble or difficult to dissolve in said solution, (ii) obtaining a solid substance which has a layer made of the substance which forms the middle layer by phase-separating the substance which forms the middle layer from the solution and (iii) reacting a monomer that is polymerizable by condensation in the presence of the solid substance that has a layer made of the substance which forms the middle layer.

2. A microencapsulation method of a solid material according to claim 1, comprising (i) preparing a dispersion phase comprising (a) an aqueous solution containing a substance having a cloud point and (b) a solid substance that is insoluble or difficult to dissolve in water, (ii) obtaining a solid substance which has a layer made of the substance having a cloud point by raising a temperature of the solution and separating the substance having a cloud point from the solution and (iii) polymerizing a monomer by condensation in the presence of the solid substance that has a layer made of the substance having a cloud point.

3. A microencapsulation method of a solid material according to claim 2, wherein the substance having a cloud point is one selected from the group consisting of polyvinyl alcohol, hydroxyalkylcelluloses and non-ionic surfactants.

4. A microencapsulation method of a solid material according to claim 1, comprising (i) preparing a dispersion phase comprising (a) an aqueous solution containing ionic substances and (b) a solid substance that is insoluble or difficult to dissolve in water, (ii) obtaining a solid substance which has a layer made of the ionic substances by varying a pH value of the solution and separating the ionic substance from the solution and (iii) polymerizing a monomer by condensation in the presence of the solid substance that has a layer made of the ionic substance.

5. A microencapsulation method of a solid material according to claim 1, comprising (i) preparing a dispersion phase comprising (a) an aqueous solution containing gelatine and (b) a solid substance that is insoluble or difficult to dissolve in water, (ii) obtaining a solid substance which has a layer made of gelatin by lowering a temperature of the solution and separating gelatin from the solution and (iii) polymerizing a monomer by condensation in the presence of the solid substance that has a layer made of gelatin.

6. A microencapsulation method of a solid material according to claim 1, comprising (i) preparing a dispersion phase comprising (a) an aqueous solution containing polyvinyl alcohol and/or sodium carboxymethylcellulose and (b) a solid substance that is insoluble or difficult to dissolve in water, (ii) obtaining a solid substance which has a layer made of polyvinyl alcohol and/or sodium carboxymethylcellulose by adding a salt to the solution and separating polyvinyl alcohol and/or sodium carboxymethylcellulose from the solution and (iii) polymerizing a monomer by condensation in the presence of the solid substance that has a layer made of polyvinyl alcohol and/or sodium carboxymethylcellulose.

7. A microencapsulation method of a solid material according to claim 1, comprising (i) preparing a dispersion phase comprising (a) an aqueous solution containing polyvinyl alcohol and (b) a solid substance that is insoluble or difficult to dissolve in water, (ii) obtaining a solid substance which has a layer made of polyvinyl alcohol by adding boric acid to the solution and separating polyvinyl alcohol from the solution and (iii) polymerizing a monomer by condensation in the presence of the solid substance that has a layer made of polyvinyl alcohol.

8. A method as recited in either claims 1, 2, 3, 4, 5, 6 or 7, wherein the monomer is polymerizable by dehydrogenation condensation.

9. A method according to claim 8, wherein the solid substance is an active ingredient of a pesticide.

10. A microcapsule of a solid substance having a middle layer wherein the microcapsule is covered by a polymer that is prepared by condensation reaction.

11. A microcapsule according to claims 10, wherein the middle layer is made of water-soluble substance.

12. A microcapsule according to claims 10, wherein the middle layer is made of water-soluble substance which has a cloud point.

13. A microcapsule according to claims 10, wherein the polymer is selected from the group consisting of melamine resin, phenol resin, urea resin, guanamine resin, polyamide resin, cross-linked polypeptide and epoxy resin.