Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media

• US 6,156,292 A
• Filed: 12/20/1996
• Issued: 12/05/2000
• Est. Priority Date: 09/17/1991
• Status: Expired due to Fees

• Current Assignee: GE Healthcare As (GE Healthcare Technologies, Inc.)
• Original Assignee: Sonus Pharmaceuticals Inc. (Achieve Life Sciences, Inc.)
• Inventors: Quay, Steven C.
• Primary Examiner(s): Hollinden, Gary E.
• Application Number:
  US08/770,522
• Time in Patent Office: 1,446 Days
• Field of Search: 424/9.52, 424/9.51, 128/662.02, 600/431
• US Class Current: 424/9.52
• CPC Class Codes: A61K 49/223 Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Abstract

Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of microbubbles comprised of the gas.

Claims

1. An ultrasound contrast medium comprising an aqueous carrier and free gas microbubbles, the free gas microbubbles including a combination of biocompatible gases, the combination including at least one fluorinated gas selected from the group consisting of octafluoropropane, dodecafluoropentane, and decafluorobutane.

2. The ultrasound contrast agent of claim 1, wherein the combination of biocompatible gases is used as a substitute for air.

3. The ultrasound contrast agent of claim 1, further including sorbitol in said aqueous carrier.

4. The ultrasound contrast agent of claim 1, wherein the fluorinated gas is dodecafluoropentane.

5. The ultrasound contrast agent of claim 1, wherein the fluorinated gas is octafluoropropane.

6. The ultrasound contrast agent of claim 1, wherein the fluorinated gas is decafluorobutane.

7. An ultrasound contrast medium comprising a gas emulsion, the gas emulsion comprising an aqueous carrier and free gas microbubbles, the free gas microbubbles including a combination of biocompatible gases, the combination including at least one fluorinated gas selected from the group consisting of octafluoropropane, dodecafluoropentane, and decafluorobutane.

8. An ultrasound contrast medium according to claim 7 wherein the fluorinated gas is dodecafluoropentane.

9. An ultrasound contrast medium according to claim 7 wherein the fluorinated gas is octafluoropropane.

10. The ultrasound contrast agent of claim 7, wherein the fluorinated gas is decafluorobutane.

11. A method of imaging organs in a living body, including a human body, comprising administering to said body an ultrasound contrast agent according to claim 7.

12. A method of imaging organs in a living body, including a human body, comprising administering to said body an ultrasound contrast agent according to claim 7.