Sustained delivery of an active agent using an implantable system
First Claim
1. A fluid-imbibing device for delivering an active agent to a fluid environment of use, said device comprising a water-swellable semipermeable material in the form of a plug that is received in sealing relationship with the interior surface of one end of an impermeable reservoir and an active agent to be displaced from the device when the water swellable material swells, wherein the semipermeable material is assembled into an open end of the reservoir.
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Accused Products
Abstract
The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
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Citations
11 Claims
- 1. A fluid-imbibing device for delivering an active agent to a fluid environment of use, said device comprising a water-swellable semipermeable material in the form of a plug that is received in sealing relationship with the interior surface of one end of an impermeable reservoir and an active agent to be displaced from the device when the water swellable material swells, wherein the semipermeable material is assembled into an open end of the reservoir.
- 4. A fluid-imbibing device for delivering an active agent to a fluid environment of use, said device comprising a water-swellable semipermeable material in the form of a plug that is received in sealing relationship with the interior surface of one end of an impermeable reservoir and an active agent to be displaced from the device when the water swellable material swells, wherein the semipermeable material is assembled into a cavity in said reservoir.
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11. A semipermeable plug useful in an active agent delivery system for delivering active agent to a fluid environment of use, wherein said system comprises an impermeable reservoir, said plug being water-swellable and expanding linearly in said delivery system to commence pumping of active agent upon insertion of the delivery system in the fluid environment of use, wherein the semipermeable plug is assembled into an open end of said reservoir.
Specification