Wound coverings for removal of interfering factors from wound fluid

• US 6,156,334 A
• Filed: 03/26/1999
• Issued: 12/05/2000
• Est. Priority Date: 03/27/1998
• Status: Expired due to Term

• Current Assignee: Tjsmith & Nephew Limited (Smith & Nephew PLC)
• Original Assignee: Beiersdorf AG (Maxingvest AG)
• Inventors: Eichner, Wolfram, Meyer-Ingold, Wolfgang, Schink, Michael, Ettner, Norbert
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): GHALI, ISIS A D
• Application Number:
  US09/276,687
• Time in Patent Office: 620 Days
• Field of Search: 424/443, 424/449, 424/486, 514/777, 514/781, 514/772.4, 514/772.6
• US Class Current: 424/443
• CPC Class Codes: A61L 15/32 Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin A61L15/225 takes precedence
• CPC Class Codes: A61L 15/38 containing enzymes
• CPC Class Codes: A61L 15/40 containing ingredients of undetermined constitution or reaction products thereof , e.g. plant or animal extracts
• CPC Class Codes: A61L 15/42 Use of materials characterised by their function or physical properties liquid bandages A61L26/00
• CPC Class Codes: Y10T 442/2525 Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Abstract

The invention relates to novel wound coverings with which interfering factors of the wound healing process can be removed from the wound fluid of chronic wounds in a controlled manner and the normal healing process is promoted.

Claims

1. A method of healing a wound comprising applying to a wound a composition comprising a carrier covalently bonded to at least one substance which interacts with interfering factors present in a wound exudate, said wound healing process being impeded by said factors, the interfering factors being ions and the substance which interacts with the interfering factors is a chelator.

2. A method according to claim 1, wherein the chelator is selected from the group consisting of deferrioxamine, diethylenetriaminepentaacetic acid, N,N'"'"'-bis-(o-hydroxybenzyl)-ethylenediamine-N,N'"'"'-diacetic acid, 1,2-dimethyl-3-hydroxy-pyrid-4-one and 1,2-dimethyl-3-hydroxyl-3-hydroxypyridin-4-one.

3. A method according to claim 2, wherein the interfering factors are iron(III) ions and the substance which interacts with the interfering factors is deferrioxamine.

4. A wound covering comprising a carrier covalently bound to at least one substance which interacts with interfering factors present in a wound exudate, which factors impede wound healing and are ions, said substance being a chelator selected from the group consisting of deferrioxamine, diethylenetriaminepentaacetic acid, N,N'"'"'-bis-(o-hydroxybenzyl)-ethylenediamine-N,N'"'"'-diacetic acid, 1,2-dimethyl-3-hydroxy-pyrid-4-one and 1,2-dimethyl-3-hydroxyl-3-hydroxypyridin-4-one.

5. A wound covering according to claim 4, wherein the interfering factors are iron(III) ions and the substance which interacts with the interfering factors is deferrioxamine.

6. A method of healing a wound comprising applying to a wound a composition comprising a carrier covalently bonded to at least one substance which interacts with interfering factors present in a wound exudate, said wound healing process being impeded by said factors, the interfering factors being selected from the group consisting of antigens, free radicals, ions, proteins, peptides, lipids and free fatty acids, said substance bonding, complexing or chelating said factors or chemically reacting with said factors.

7. A wound covering comprising a carrier covalently bound to at least one substance which interacts with interfering factors present in a wound exudate, which factors impede wound healing and are selected from the group consisting of antigens, free radicals, ions, proteins, peptides, lipids and free fatty acids, said substance bonding, complexing or chelating said factors or chemically reacting with said factors.