Micro optical fiber sensor device

• US 6,157,442 A
• Filed: 06/19/1998
• Issued: 12/05/2000
• Est. Priority Date: 06/19/1998
• Status: Expired due to Term

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: MicroSense International, LLC
• Inventors: Raskas, Eric J.
• Primary Examiner(s): Font, Frank G.
• Assistant Examiner(s): Ratliff, Reginald A.
• Application Number:
  US09/100,295
• Time in Patent Office: 900 Days
• Field of Search: 356/39, 356/317, 356/320, 356/40
• US Class Current: 356/39
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: G01N 2400/00 Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
• CPC Class Codes: G01N 33/5438 Electrodes

Abstract

A sensor device for measuring a concentration of a substance within a sample comprises a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample, a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the active material interacting with a substance within a sample to change the wavelength of the emitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light out of the second end thereof, an optical detector for receiving the reflected beam of light from the second end of the sensor for producing a signal indicative of the reflected beam of light, and a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample.

Claims

1. A sensor device for measuring a concentration of a substance within a sample comprising:

a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample;

a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the active material interacting with a substance within a sample to change the wavelength of the emitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light out of the second end thereof;

means for receiving the reflected beam of light from the second end of the sensor for producing a signal indicative of the reflected beam of light; and

a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample.

2. The sensor device of claim 1 wherein the active material is preselected to interact with a predetermined substance within a sample.

3. The sensor device of claim 1 wherein the reflected beam of light has a wavelength which is different from the wavelength of the emitted beam of light.

4. The sensor device of claim 1 wherein the receiving means is an optical detector.

5. The sensor device of claim 1 wherein the concentration to be measured is glucose and the sample is a human.

6. The sensor device of claim 1 further comprising a pencil shaped and sized body having a tip portion, a central body, and an end cap.

7. The sensor device of claim 1 wherein the tip portion comprises a biologically active compound that is immobilized in an environment that is optically reactive.

8. A sensor device for measuring a concentration of a substance within a sample comprising:

a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and an active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the active material capable of interacting with a substance within a sample;

a light source for emitting a beam of light of a preselected wavelength with the light source being coupled to an optical device capable of transmitting the beam of light therethrough, the transmitted beam of light being directed into the first end of the sensor, through the sensor, and out of the second end into a sample, the active material interacting with a substance within a sample to change the wavelength of the transmitted beam of light to produce a reflected beam of light and the sensor for transmitting the reflected beam of light from the second end, through the sensor, and out of the first end thereof, the optical device being further capable of reflecting the reflected beam of light;

means for receiving the reflected beam of light which is reflected by the optical device for producing a signal indicative of the reflected beam of light; and

a processor for receiving the signal indicative of the reflected beam of light and for processing the signal to determine the concentration of a substance within a sample.

9. The sensor device of claim 8 wherein the active material is preselected to interact with a predetermined substance within a sample.

10. The sensor device of claim 8 wherein the reflected beam of light has a wavelength which is different from the wavelength of the transmitted beam of light.

11. The sensor device of claim 8 wherein the receiving means is an optical detector.

12. The sensor device of claim 8 wherein the concentration to be measured is glucose and the sample is a human.

13. The sensor device of claim 8 further comprising a pencil shaped and sized body having a tip portion, a central body, and an end cap.

14. The sensor device of claim 8 wherein the tip portion comprises a biologically active compound that is immobilized in an environment that is optically reactive.

15. A sensor device for measuring a concentration of a substance within a sample comprising:

a sensor comprising an optical fiber portion having a first end and a second end, the second end having a tip portion attached thereto and a first and a second active material incorporated within the tip portion, the tip portion adapted to be inserted into a sample, the first active material capable of interacting with a first substance within a sample and the second active material capable of interacting with a second substance within a sample;

a light source coupled to the first end of the sensor for emitting a beam of light into and through the sensor and into a sample, the emitted beam of light having a wavelength and the first active material interacting with a first substance within a sample to change the wavelength of the emitted beam of light to produce a first reflected beam of light, the second active material interacting with a second substance within a sample to change the wavelength of the emitted beam of light to produce a second reflected beam of light, and the sensor for transmitting the first and second reflected beams of light out of the second end thereof;

means for receiving the first and second reflected beams of light from the second end of the sensor for producing a first signal indicative of the first reflected beam of light and a second signal indicative of the second reflected beam of light; and

a processor for receiving the first and second signals and for processing the first and second signals to determine the concentration of a first substance within a sample and the concentration of a second substance with a sample.

16. The sensor device of claim 15 wherein the receiving means comprises a first means for receiving the first reflected beam of light and a second means for receiving the second beam of light.

17. The sensor device of claim 16 wherein the first means for receiving is an optical detector and the second means for receiving is an optical detector.

18. The sensor device of claim 15 wherein the first concentration to be measured is glucose and the sample is a human.

19. The sensor device of claim 15 further comprising a pencil shaped and sized body having a tip portion, a central body, and an end cap.

20. The sensor device of claim 15 wherein the tip portion comprises a biologically active compound that is immobilized in an environment that is optically reactive.