Ventilatory system with additional gas administrator

• US 6,158,434 A
• Filed: 11/13/1998
• Issued: 12/12/2000
• Est. Priority Date: 02/27/1996
• Status: Expired due to Fees

• Current Assignee: Henk W. Koster
• Original Assignee: Henk W. Koster
• Inventors: Grootendorst, Albert, Lugtigheid, Gerard
• Primary Examiner(s): Lewis, Aaron J.
• Assistant Examiner(s): MITCHELL, TEENA KAY
• Application Number:
  US09/125,851
• Time in Patent Office: 760 Days
• Field of Search: 128/204.18, 128/204.21, 128/204.22, 128/204.23, 128/205.24, 128/205.11
• US Class Current: 128/204.22
• CPC Class Codes: A61M 16/0833 T- or Y-type connectors, e.g. Y-piece
• CPC Class Codes: A61M 16/085 Gas sampling
• CPC Class Codes: A61M 16/1015 using a gas flush valve, e.g. oxygen flush valve
• CPC Class Codes: A61M 16/1055 bacterial
• CPC Class Codes: A61M 16/107 in the inspiratory path
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 16/202 electrically actuated
• CPC Class Codes: A61M 16/204 used for inhalation control
• CPC Class Codes: A61M 16/205 used for exhalation control
• CPC Class Codes: A61M 16/208 Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
• CPC Class Codes: A61M 2016/102 Measuring a parameter of the content of the delivered gas
• CPC Class Codes: A61M 2016/1025 the O2 concentration
• CPC Class Codes: A61M 2016/1035 the anaesthetic agent concentration
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: B01D 19/0063 Regulation, control including valves and floats for construction and details of valves F16K

Abstract

A ventilatory system for ventilating a patient includes a gas administration module for administering a predetermined amount of an additional gas, such as NO, to the patient, the gas administration module being provided with a predetermined number of parallel valve units each provided with a throttle valve and a controlled valve in series, the internal volume between the throttle valve and the controlled valve being so small that no interfering effects occur due to opening and closing of the controlled valve with a frequency below a maximum frequency. Preferably, the system is also provided with a tracheal gas insufflation (TGI) module and a measurement system for measuring the concentration of the additional gas.

Claims

1. A ventilatory system for ventilating a patient, comprising:

a ventilator provided with at least one first inlet for supplying a predetermined first gas mixture to said ventilator and at least one outlet for supplying a controlled amount of said predetermined first gas mixture to said patient during inspiration intervals; and

a gas administration module connected either downstream or upstream from said ventilator and arranged for administering a predetermined amount of an additional gas to said patient, said gas administration module being provided with a predetermined number of valve units which are connected in parallel and can each be independently switched between a closed state and an open state for supplying a predetermined amount of said additional gas to said patient, each of the valve units being provided with a series connection of a throttle valve with a throttle valve inlet and outlet and a controlled valve with a controlled valve inlet and outlet, said controlled valve being switchable between an open and a closed state with a predetermined frequency, said throttle valve outlet being connected to said controlled valve inlet such that there is a passage with a volume V between said throttle valve and said controlled valve that is selected to be so small that the pressure within the passage is returned to the pressure at the throttle valve inlet at any time the controlled valve opens.

2. A ventilatory system according to claim 1 where any of said throttle valves is a needle valve provided with an outlet element having an orifice and an adjustable stem assembly for at least partly closing off said orifice.

3. A ventilatory system according to claim 1 where said volume V is less than 10 mm³.

4. A ventilatory system according to claim 3 where said volume V is less than 3 mm³.

5. A ventilatory system according to claim 1 where said frequency corresponds to switching said controlled valve at least 5 times every inspiration interval.

6. A ventilatory system according to claim 1 where said valve units in their open states allow flow rates rising from a predetermined low value to a predetermined high value in accordance with a predetermined mathematical relationship.

7. A ventilatory system according to claim 6 where said mathematical relation corresponds to a binary flow bench.

8. A ventilatory system according to claim 1 where said additional gas is NO gas.

9. A ventilatory system according to claim 6 where said additional gas is NO gas and said flow rates are selected to allow administration of additional NO gas to said predetermined first gas mixture in a range of 0.05 ppm to 100 ppm.

10. A ventilatory system according to claim 1 where any of said controlled valves is an electromagnetic valve.

11. A ventilatory system according to claim 1 where said ventilator is provided with an electrical ventilator output for providing control signals and said gas administration module is provided with an electrical input coupled to said electrical ventilator output for receiving said control signals in order to automatically control said supplying said predetermined amount of said additional gas to said patient.

12. A ventilatory system according to claim 11 where said electrical input is provided with at least a first input for receiving a flow control signal for controlling the amount of administered additional gas and a second input for receiving an inspiration control signal for controlling that the additional gas is administered at least during inspiration intervals of said patient.

13. A ventilatory system according to claim 12 where said gas administration module is provided with an electronic gas administration module which has a first amplifier connected to said first input and having a gain switchable between a high and a low value by means of a gain switch, the high and low values of said gain corresponding to normal and high flow applications, respectively.

14. A ventilatory system according to claim 13 where said electronic gas administration module is provided with a divider having a divider input connected to said second input for receiving said inspiration control signal and having a divider output for providing a divider output signal which corresponds to said inspiration control signal divided by a selectable dividing number, said divider output being connected to drivers of said valve units for controlling time sections of inspiration intervals during which said additional gas is administered.

15. A ventilatory system according to claim 13 where said electronic gas administration module is provided with a third input for receiving an expiration control signal, a logic unit either connectable to said third input through a further divider or to a predetermined voltage by a second switch which is switched concurrently with said gain switch and which logic unit, when connected to said third input, is arranged for opening a preselected number of said valve units during expiration intervals and, when connected to said predetermined voltage, is arranged for closing at least one of said preselected number of said valve units during expiration intervals.

16. A ventilatory system according to claim 1 further comprising a TGI module provided with a pneumatic TGI module and an electronic TGI module, said pneumatic TGI module having a TGI inlet for receiving a predetermined second gas mixture and a TGI outlet for providing a predetermined amount of said second gas mixture, at least one TGI valve unit connected between said TGI inlet and said TGI outlet, and a pressure limiting security valve connected downstream from said at least one TGI valve unit, said electronic TGI module having an electrical driving unit connected to said at least one TGI valve unit for controlling opening and closing of said at least one TGI valve unit.

17. A ventilatory system according to claim 16 where said at least one TGI valve unit comprises a first TGI valve connected to the TGI inlet and a second TGI valve connected downstream from said first TGI valve, said electrical driving unit having a first electrical driver connected to said first TGI valve and a second electrical driver connected to said second TGI valve, said electronic TGI module and said first and second electrical drivers being arranged to open said first TGI valve outside inspiration flow intervals and to open said second TGI valve outside inversed inspiration intervals.

18. A ventilatory system according to claim 16 where said first TGI valve means are provided with a first and a second controlled TGI valve in parallel, and said second TGI valve means are provided with a third and a fourth controlled TGI valve in parallel.

19. A ventilatory system according to claim 16 where said TGI inlet is connected to an air supply and an oxygen supply through a series connection of a blender, a needle valve, and a flow meter.

20. A ventilatory system according to claim 16 where said pneumatic TGI module is provided with a pressure sensor to measure the pneumatic TGI module outlet pressure and to transmit a corresponding TGI outlet pressure signal to said electronic TGI module and said electronic TGI module is arranged to close said at least one TGI valve means whenever said TGI outlet pressure is not within a predetermined adjustable range.

21. A ventilatory system according to claim 1 further comprising a measuring system comprising a measuring chamber, at least one gas component measuring sensor within said measuring chamber, a sample port for receiving gas samples, a water separator provided with a water separator inlet connected to said sample port, said water separator having a cooling unit for cooling said water separator to a dewpoint temperature between 0°

C. and 10°

C., a first water separator outlet connected to a water discharge for draining separated water, and a second water separator outlet connected to said measuring chamber for providing dried gas samples.

22. A ventilatory system according to claim 21 where said water separator is provided with a predetermined volume of cooling liquid which is cooled by said cooling unit, the water separator being arranged such that, in operation, the gas samples are led through said cooling liquid.

23. A ventilatory system according to claim 22 further provided with a cooling liquid level control unit for controlling the level of said cooling liquid within said water separator.

24. A ventilatory system according to claim 21 where the measuring chamber comprises an NO sensor, an O₂ sensor, an NO₂ sensor, and a pressure sensor.

25. A ventilatory system according to claim 24 where said sample port is connected downstream from said gas administration module.