Infrared laser catheter system

• US 6,159,203 A
• Filed: 08/15/1990
• Issued: 12/12/2000
• Est. Priority Date: 07/31/1985
• Status: Expired due to Fees

• Current Assignee: Cardiofocus Incorporated
• Original Assignee: Cardiofocus Incorporated
• Inventors: Sinofsky, Edward Lawrence
• Primary Examiner(s): Shay, David M.
• Application Number:
  US07/568,348
• Time in Patent Office: 3,772 Days
• Field of Search: 128/395, 128/394, 128/348, 128/898, 606/2-19
• US Class Current: 606/7
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 2018/2065 Multiwave; Wavelength mixing, e.g. using four or more wavelengths pilot laser A61B2018/2025
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: G02B 6/4296 coupling with sources of high radiant energy, e.g. high power lasers, high temperature light sources

Abstract

Laser energy produced by a laser operating in the mid-infrared region (approximately 2 micrometers) is delivered by an optical fiber in a catheter to a surgical site for biological tissue removal and repair. Disclosed laser sources which have an output wavelength in this region include: Holmium-doped Yttrium Aluminum Garnet (Ho:YAG), Holmium-doped Yttrium Lithium Fluoride (Ho:YLF), Erbium-doped YAG, Erbium-doped YLF and Thulium-doped YAG. For tissue removal, the lasers are operated with relatively long pulses at energy levels of approximately 1 joule per pulse. For tissue repair, the lasers are operated in a continuous wave mode at low power. Laser output energy is applied to a silica-based optical fiber which has been specially purified to reduce the hydroxyl-ion concentration to a low level. The catheter may be comprised of a single optical fiber or a plurality of optical fibers arranged to give overlapping output patterns for large area coverage.

Claims

1. A system for the removal of biological tissue within a body:

a laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength in a range of 1.4-2.2 micrometers and for operating said laser energy source at an energy level sufficient to remove biological tissue;

an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and

means for directing an output of said laser source to the proximal end of said optical fiber.

2. A system in accordance with claim 1 wherein said optical fiber comprises a silica fiber purified to reduce an hydroxyl ion content sufficiently to allow transmission of laser energy from said laser energy source to the surgical site at said wavelength range of 1.4-2.2 micrometers and at said energy level sufficient to remove biological tissue.

3. A system in accordance with claim 1 wherein said laser source comprises a Holmium-doped Yttrium-Aluminum-Garnet laser.

4. A system in accordance with claim 1 wherein said laser source comprises an Erbium-doped Yttrium-Aluminum-Garnet laser.

5. A system in accordance with claim 1 wherein said laser source comprises a Holmium-doped Yttrium-Lithium-Fluoride laser.

6. A system in accordance with claim 1 wherein said laser source comprises an Erbium-doped Yttrium-Lithium-Fluoride laser.

7. A system in accordance with claim 1 wherein said laser source comprises a Thulium-doped Yttrium-Aluminum-Garnet laser.

8. A system in accordance with claim 1 further comprising an aiming laser source means for generating visible light output and means for directing said visible light output through said laser source and said optical fiber to align said laser and said fiber and to visually illuminate said surgical site.

9. A system in accordance with claim 1 wherein said laser source includes means for operating said laser source with a pulse width of about 0.2-5 milliseconds.

10. A system in accordance with claim 1 wherein said laser energy source includes means for operating said laser energy source at a repetition rate in a range of from about 1 to about 10 pulses per second.

11. A system for the removal of biological tissue within a body comprising:

a laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength in a range of 1.4-2.2 micrometers and for operating said laser energy source at an energy level sufficient to remove biological tissue;

a catheter having at least one lumen passing therethrough;

at least one optical fiber comprised of silica passing through said catheter lumen, said silica fiber being purified to reduce the hydroxyl ion content as low as possible, said optical fiber conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and

means for directing an output of said laser source to the proximal end of said optical fiber.

12. A system for the removal of biological tissue within a body comprising:

a Holmium-doped laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength in a range of about 2.06-2.1 micrometers and for operating said laser energy source at an energy level sufficient to remove biological tissue;

an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and

means for directing an output of said laser source to the proximal end of said optical fiber.

13. A system for the removal of biological tissue within a body comprising:

a laser energy source including means for operating said laser energy source in a pulsed mode with an output wavelength in a range of about 1.4-2.2 micrometers and for operating said laser energy source at an energy level sufficient to deliver energy to a surgical site of at least about 0.57 joules per square millimeter per pulse to remove biological tissue within the body;

an optical fiber for conducting laser energy from said laser energy source from a proximal end of said fiber to a surgical site at a distal end of said optical fiber; and

means for directing the output of said laser energy source to the proximal end of said optical fiber.

14. A system in accordance with claim 13 wherein said optical fiber comprises a silica fiber purified to reduce an hydroxyl ion content sufficiently to allow transmission of laser energy from said laser energy source to the surgical site at said wavelength range of about 1.4-2.2 micrometers and at said energy of at least about 0.57 joules per square millimeter per pulse.

15. A system in accordance with claim 13 wherein said laser source comprises a Holmium-doped Yttrium-Aluminum-Garnet laser.

16. A system in accordance with claim 13 wherein said laser source comprises an Erbium-doped Yttrium-Aluminum-Garnet laser.

17. A system in accordance with claim 13 wherein said laser source comprises a Holmium-doped Yttrium-Lithium-Fluoride laser.

18. A system in accordance with claim 13 wherein said laser source comprises an Erbium-doped Yttrium-Lithium-Fluoride laser.

19. A system in accordance with claim 13 wherein said laser source comprises a Thulium-doped Yttrium-Aluminum-Garnet laser.

20. A method for the removal of biological tissue within a body comprising the steps of:

inserting a catheter containing an optical fiber into the body;

guiding a distal end of the optical fiber to a surgical site within the body;

operating a laser energy source in a pulsed mode with an output beam having a wavelength in a range of from about 1.4 to about 2.2 micrometers and at an energy level sufficient to remove biological tissue;

directing the output of the laser energy source to a proximal end of the optical fiber; and

directing laser energy propagating down the optical fiber to the surgical site at the distal end of the optical fiber.

21. A method for the removal of biological tissue in accordance with claim 20 wherein said operating step comprises the step of operating said laser energy source at an energy level sufficient to deliver energy to a surgical site of at least about 0.57 joules per square millimeter per pulse.

22. A method for the removal of biological tissue in accordance with claim 20 wherein said operating step comprises the step of operating said laser energy source with a pulse width of about 0.2-5 milliseconds.

23. A method for the removal of biological tissue in accordance with claim 20 wherein said operating step comprises the step of operating said laser energy source at a repetition rate in the range of from about 1 to about 10 pulses per second.

24. A method for the removal of biological tissue in accordance with claim 20 wherein said operating step comprises the step of operating said laser energy source with an output beam having a wavelength in a range of about 2.06-2.10 micrometers.

25. A method for the removal of biological tissue in accordance with claim 20 further comprising the step of reducing an hydroxyl ion content of the optical fiber sufficiently to allow transmission of laser energy from the laser energy source to the surgical site at said wavelength range of from about 1.4 to about 2.2 micrometers and at said energy level sufficient to remove biological tissue.

26. A method for the removal of biological tissue in accordance with claim 20 wherein said operating step comprises the step of operating said laser energy source with an output beam having a wavelength of about 1.88 micrometers.