Expandable treatment device for photodynamic therapy and method of using same

• US 6,159,236 A
• Filed: 01/28/1999
• Issued: 12/12/2000
• Est. Priority Date: 01/28/1999
• Status: Expired due to Term

• Current Assignee: Advanced Photodynamic Technologies, Inc. (Ondine Biomedical, Inc.)
• Original Assignee: Advanced Photodynamic Technologies, Inc. (Ondine Biomedical, Inc.)
• Inventors: Biel, Merrill A.
• Primary Examiner(s): Dvorak, Linda C. M.
• Assistant Examiner(s): RAM, JOCELYN D
• Application Number:
  US09/239,353
• Time in Patent Office: 684 Days
• Field of Search: 606/2, 606/3, 606/13-16, 606/21, 607/88, 607/89, 607/92, 604/20, 604/21, 604/96
• US Class Current: 607/92
• CPC Class Codes: A61B 2018/2261 with scattering, diffusion or dispersion of light
• CPC Class Codes: A61M 2205/051 with radiation therapy
• CPC Class Codes: A61M 2205/587 Lighting arrangements
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61N 2005/0609 Stomach and/or esophagus
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

The invention relates to a medical device including a tube and expandable member and one or more light sources disposed in an elongated member disposed in the tube. The light sources emit energy for photodynamic therapy through a window to the treatment area. The treatment device may further include a heat and/or light dissipating layer, such as a layer of gold alloy paint, or other light blocking material.

Claims

1. A medical device for photodynamic therapy comprising:

a tube having a proximal end, a distal end and a lumen therein, an expandable member disposed on a distal portion of the tube, the expandable member configured to expand and contract to one or more states; and

an elongated member providing one or more light sources, the elongated member disposed in at least a portion of the tube, the one or more light sources configured to emit energy for photodynamic therapy, and wherein the elongated member is slidably movable within the lumen of the elongated tube.

2. The medical device for photodynamic therapy of claim 1 wherein the energy for photodynamic therapy passes through at least a portion of the medical device.

3. The medical device for photodynamic therapy of claim 2 wherein the energy for photodynamic therapy passes substantially unrestricted through at least a portion of the medical device.

4. The medical device for photodynamic therapy of claim 1 wherein the one or more light sources provides light wavelengths ranging from about 450 nm to about 850 nm;

a light dosage rate ranging from about 0 mw/cm² to about 150 mw/cm² ; and

a light dose ranging from 0 J/cm² to about 300 J/cm².

5. The medical device for photodynamic therapy of claim 1 wherein the expandable member has a cross-sectional shape that is triangular-like.

6. The medical device for photodynamic therapy of claim 1 further comprising a layer of gold or gold alloy disposed on the expandable member.

7. The medical device for photodynamic therapy of claim 1 wherein at least a portion of the elongated member is made of alight diffusing material.

8. The medical device for photodynamic therapy of claim 1 further comprising a remote light source operatively coupled to the elongated member via at least one of a fiber optic element, a plurality of internal filaments, or one or more VCSELs.

9. The medical device for photodynamic therapy of claim 1 wherein the elongated member is configured to treat disease in the throat or cheek.

10. The medical device for photodynamic therapy of claim 1 wherein the expandable member is made of a polymer.

11. The medical device for photodynamic therapy of claim 1 wherein the tube and the expandable member further including a window for substantially unobstructed delivery of a light emitting source to a portion of a body.

12. A medical device for photodynamic therapy comprising:

a catheter having a balloon disposed thereon, said catheter providing a lumen therewithin for ventilation purposes, the balloon configured to be juxtaposed to one or more body portions; and

one or more light sources in light communication with the balloon, the one or more light sources configured to emit energy from the balloon for photodynamic therapy;

wherein the one or more light sources provide light wavelengths ranging from about 450 nm to about 850 nm;

a light dosage rate ranging from about 0 to mw/cm² to about 150 mw/cm² ; and

a light dose ranging from 0 J/cm² to about 300 J/cm².

13. A method of using a light emitting treatment device comprising the steps of:

identifying a treatment site in a body;

providing a tube having a proximal end, a distal end and a lumen therein, an expandable member being disposed proximate the distal end of the tube;

providing an elongated member having one or more light sources, the elongated member being disposed in at least a portion of the tube;

providing a control device coupled to the light source to provide at least one of a range of intensity or selective operation of an emitted light energy;

disposing the expandable member at the treatment site;

positioning the expandable member to direct the light source to emit energy at the treatment site, the one or more light sources configured to provide light wavelengths ranging from about 450 nm to about 850 nm;

a light dosage rate ranging from about 0 mw/cm² to about 150 mw/cm² ; and

a light dose ranging from 0 J/cm² to about 300 J/cm² ; and

activating the light source and the control device for a period of time to emit energy at the treatment site for photodynamic therapy.

14. A light emitting treatment device comprising:

an expandable member configured to conform to one or more treatment surfaces;

one or more light members in light communication with the expandable member;

wherein the expandable member and the one or more light members form an assembly and the one or more light members are configured to emit energy from the assembly for photodynamic therapy of the one or more treatment surfaces; and

one or more light detectors in light communication with the expandable member and configured to provide monitoring of the one or more treatment surfaces.

15. The light emitting treatment device of claim 14 wherein the monitoring includes at least one of light wavelength (nm), light dosage (joules/cm²), or light dosage rate (mw/cm²).

16. A medical device for photodynamic therapy comprising:

a tube having a proximal end, a distal end and a lumen therein, an expandable member disposed on a distal portion of the tube, the expandable member configured to expand and contract to one or more states; and

an elongated member providing one or more light sources, said elongated member being disposed in at least a portion of the tube, the one or more light sources configured to emit energy for photodynamic therapy; and

a heat dissipating layer disposed on a portion of either the tube or the elongated member or both.

17. A medical device for photodynamic therapy comprising:

a tube having a proximal end, a distal end and a lumen therein, an expandable member disposed on a distal portion of the tube, the expandable member configured to expand and contract to one or more states;

one or more light sources disposed in at least a portion of the tube, the one or more light sources configured to emit energy for photodynamic therapy; and

a control device operatively coupled to the light source to provide at least one of a range of intensity or selective operation of the emitted energy.

18. A light emitting treatment device comprising:

an expandable member configured to conform to one or more treatment surfaces, a portion of the expandable member being configured to substantially restrict light energy for photodynamic therapy from exiting the treatment device; and

one or more light members in light communication with the expandable member, wherein the expandable member and the one or more light members form an assembly and the one or more light members are configured to emit energy from the assembly for photodynamic therapy of the one or more treatment surfaces.

19. A method of using a light emitting treatment device comprising the steps of:

identifying a treatment site in a body;

disposing the expandable member at the treatment site;

providing a light source in light communication with the expandable member;

injecting a drug or dye at the treatment site;

positioning the expandable member to direct the light source to emit energy at the treatment site, the one or more light sources configured to provide light wavelengths ranging from about 450 nm to about 850 nm;

a light dosage rate ranging from about 0 mw/cm² to about 150 mw/cm² ; and

a light dose ranging from 0 J/cm² to about 300 J/cm² ; and

activating the light source for a period of time to emit energy at the treatment site for photodynamic therapy.

20. A medical device for photodynamic therapy comprising:

a catheter having a distal end adapted to be placed within a cavity of a body, said catheter providing a lumen for respiratory ventilation purposes of the body; and

one or more light sources in light communication with the catheter, the one or more light sources configured to emit energy for photodynamic therapy;

wherein the one or more light sources provide light wavelengths ranging from about 450 nm to about 850 nm;

a light dosage rate ranging from about 0 mw/cm² to about 150 mw/cm² ; and

a light dose ranging from 0 J/cm² to about 300 J/cm².