Patch applicator

• US 6,159,497 A
• Filed: 08/03/1999
• Issued: 12/12/2000
• Est. Priority Date: 10/30/1998
• Status: Expired due to Term

• Current Assignee: Noven Pharmaceuticals (Hisamitsu Pharmaceutical Company Incorporated)
• Original Assignee: Noven Pharmaceuticals (Hisamitsu Pharmaceutical Company Incorporated)
• Inventors: LaPrade, Ronald, Wick, John J.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): GHALI, ISIS A D
• Application Number:
  US09/368,014
• Time in Patent Office: 497 Days
• Field of Search: 128/155, 128/156, 424/448, 424/449
• US Class Current: 424/448
• CPC Class Codes: A61F 15/005 Bandage applicators
• CPC Class Codes: A61F 2013/00906 for transcutaneous or transdermal drugs application
• CPC Class Codes: A61F 2013/0296 for making transdermal patches (chemical processes excluded)
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
• CPC Class Codes: A61K 9/7038 Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer

Abstract

A patch applicator for easy application of a transdermal patch is disclosed, wherein the applicator is especially suitable for a small transdermal patch of size 20 cm² or less. The patch applicator includes a rigid release liner and a flexible transdermal patch releasably attached to the release liner. The release liner has a first and second poritons separated by a slit, and pulltabs affixed to the portions. The pulltabs can extend beyond an end margin of the transdermal patch, and preferably extend outwardly at an acute angle for use, so that a patch user may easily grasp the pulltabs and remove a first portion of the release liner from the patch. The patch is then applied to the skin or mucosa, followed by removal of the second portion and final application of the patch. The patch applicator reduces loss in manufacturing yield, and especially benefits the elderly population.

Claims

1. A transdermal patch comprising:

a patch adhesive layer including a therapeutically effective amount of at least one drug to be delivered to a patient and a backing layer;

a release liner releasably affixed to said patch adhesive layer, said release liner substantially covering said adhesive layer until removal for application, and comprising a first portion, a second portion, and a slit separating said first and second portions; and

first and second pulltabs, wherein said first pulltab is affixed to said first portion of said release liner, and said second pulltab is affixed to said second portion of said release liner.

2. The transdermal patch of claim 1, wherein said slit is a score line.

3. The transdermal patch of claim 1, wherein said slit is completely cut through said release liner.

4. The transdermal patch of claim 1, wherein at least one of said pulltabs extends beyond an end margin of said transdermal patch.

5. The transdermal patch of claim 1, wherein said first and second pulltabs each comprise a first region and a second region, wherein said first and second regions are separated by a fold.

6. The transdermal patch of claim 5, said fold comprises a score line.

7. The transdermal patch of claim 5, wherein said first region of said first pulltab is affixed to said first portion, and said first region of said second pulltab is affixed to said second portion.

8. The transdermal patch of claim 5, wherein said second regions of said first and second pulltabs are folded upon said first regions so as to extend outwardly from said release liner at an acute angle from said first portions.

9. The transdermal patch of claim 1, wherein said transdermal patch has an area of 20 cm² or less.

10. The transdermal patch of claim 1, wherein said transdermal patch has an area of 10 cm² or less.

11. The transdermal patch of claim 1, wherein said patch adhesive layer comprises a drug.

12. The transdermal patch of claim 1, wherein said release liner is substantially more rigid than said backing layer.

13. The transdermal patch of claim 1, wherein said release liner is fabricated from at least one material selected from the group consisting of cellophane, nylon, glassine paper, acrylonitrile polymers, acrylic polymers, paper, silicones, fluoropolymers, polyesters, polyvinyl resins, polyethylene, and cellulose acetate.

14. The transdermal patch of claim 1, wherein said release liner has a thickness of from about 3 mils to about 6 mils.

15. The transdermal patch of claim 1, wherein said pulltabs are affixed with an adhesive.

16. The transdermal patch of claim 1, wherein said pulltabs are affixed by thermobonding or fusion bonding.

17. The transdermal patch of claim 1, wherein said first tab and said second tab are of unequal areas.

18. The transdermal patch of claim 5, wherein said fold creates an angle of approximately 30 to 60 degrees between said first and second portions of said pulltabs.

19. A transdermal patch comprising:

a patch adhesive layer and a backing layer on which said patch adhesive layer is provided;

a release liner releasably affixed to said patch adhesive layer, said release liner comprising first and second portions and a slit separating said first and second portions, said release liner being substantially more rigid than said backing layer; and

first and second pulltabs, said pulltabs each comprising first and second ends with a first end adapted to be grasped by a user, and a second end affixed to one of said first and second portions of said release liner adjacent said slit, wherein said pulltabs are pulled by the user to translate a pulling force to said second end of said pulltab to cause separation of said first and second portion of said release liner at said slit due to the different rigidity of said release liner relative to said backing layer.

20. The transdermal patch of claim 19, wherein said transdermal patch has an area of 20 cm² or less.

21. The transdermal patch of claim 19, wherein said release liner has a thickness of from about 3 mils to about 6 mils.

22. The transdermal patch of claim 19, wherein said release liner has first and second sections having a bend therebetween, said second section being folded about said bend so as to be disposed at an acute angle relative to said first section for use.

23. The transdermal patch of claim 19, wherein said fold comprises a score line.

24. The transdermal patch of claim 19, wherein at least one of said pulltabs extends beyond an end margin of said transdermal patch.