Alkali metal and alkaline-earth metal salts of acetaminophen
First Claim
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1. An isolated alkali metal or alkaline-earth metal salt of acetaminophen.
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Abstract
Isolated salts of acetaminophen are disclosed. Alkali metal and alkaline-earth metal salts of acetaminophen were formed by reacting the free acid of acetaminophen with the corresponding metal hydroxide and then immediately isolating the resulting salt. These salts have been found to be more water soluble and less bitter in taste than the free acid form of acetaminophen. The isolated salts may also be combined with other active ingredients.
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64 Claims
- 1. An isolated alkali metal or alkaline-earth metal salt of acetaminophen.
- 8. A method of treating a mammal in need of an analgesic or antipyretic agent, comprising the oral administration of a therapeutically effective amount of an isolated alkali metal or alkaline-earth metal salt of acetaminophen.
- 14. A method of eliciting an analgesic or antipyretic response in a mammal, comprising the oral administration of a therapeutically effective amount of an isolated alkali metal or alkaline-earth metal salt of acetaminophen.
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20. The isolated compound:
- ##STR3## wherein n is 1 or 2, M is alkali metal when n is 1 and M is alkaline-earth metal when n is 2 and x is from 0 to about 10.
- View Dependent Claims (21, 22, 23, 24, 25)
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26. A method of preparing an isolated alkali metal or alkaline-earth metal salt of acetaminophen, comprising:
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reacting acetaminophen with an alkali metal or alkaline-earth metal metal hydroxide in the presence of a solvent to form a reaction mixture and immediately recovering the resulting salt from the reaction mixture. - View Dependent Claims (27, 28, 29)
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30. A method of preparing an anhydrous, isolated salt of acetaminophen, comprising:
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contacting a monovalent metal salt of acetaminophen with a divalent metal cation whereby a divalent metal salt of acetaminophen is formed via a cation exchange reaction and immediately recovering the resulting anhydrous, divalent metal salt of acetaminophen. - View Dependent Claims (31, 32, 33)
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- 34. A composition comprising an isolated alkali metal or alkaline-earth metal salt of acetaminophen and at least one other active ingredient selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, gastrointestinal agents, diuretics, bronchodilators and, sleep-inducing agents or a mixture thereof.
- 51. A pharmaceutical composition comprising the isolated compound ##STR4## wherein n is 1 or 2, M is alkali metal when n is 1 and M is alkaline-earth metal when n is 2 and x is from 0 to about 10, and at least one other active ingredient selected from the group consisting of analgesics, decongestants, expectorants, antitussives, antihistamines, gastrointestinal agents, diuretics and bronchodilators or a mixture thereof.
Specification