Pacemaker system with diurnal pattern controlled overdrive for prevention of tachycardia

• US 6,161,041 A
• Filed: 10/26/1998
• Issued: 12/12/2000
• Est. Priority Date: 10/26/1998
• Status: Expired due to Fees

• Current Assignee: Vitatron Medical BV (Medtronic Plc)
• Original Assignee: Vitatron Medical BV (Medtronic Plc)
• Inventors: De Vries, Bernhard, Stoop, Gustaaf A. P.
• Primary Examiner(s): Layno, Carl H.
• Application Number:
  US09/179,043
• Time in Patent Office: 778 Days
• Field of Search: 607/14, 607/25, 600/516
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions

Abstract

There is provided a cardiac pacemaker system with a ventricular tachycardia prevention feature, whereby the pacemaker monitors ventricular activity during each patient awakening period to determine when VT is likely. In a preferred embodiment, QRS and T wave templates are generated cyclically during awakening, and compared to normal templates to obtain a measure of variability, indicative of refractory dispersion and thus of probable VT. Ventricular extra-systoles are also monitored and analyzed during the awakening period to see how closely they occur to the ventricular vulnerable period. When the monitored data indicates VT probability during awakening, the pacemaker responds by overdriving the heart with an intervention pacing rate which is continually adjusted as a function of the currently obtained data.

Claims

1. A cardiac pacemaker system for pacing a patient, having VP means for generating and delivering ventricular pacing pulses to a patient'"'"'s ventricle, VS means for sensing ventricular QRS and T waves, rate means for determining the patient'"'"'s spontaneous heart rate, and control means for controlling when said VP means generates and delivers ventricular pacing pulses and the pacing rate of such pulses, wherein said control means further comprises VT prevention means for controlling said VP means to deliver pacing pulses at a rate overriding the patient'"'"'s spontaneous rate when a threshold of refractory dispersion is detected during patient awakening, said VT prevention means comprising:

awakening means for determining an awakening period when the patient is awakening;

depolarization means for determining a first measure of dispersion of the patient'"'"'s depolarization wave during awakening;

repolarization means for determining a second measure of dispersion of the patient'"'"'s repolarization wave during awakening; and

intervention means for controlling said VP means to generate and deliver pacing pulses at an intervention rate that overrides the patient'"'"'s spontaneous rate as a function of said first and second measures.

2. The system as described in claim 1, wherein said VT prevention means comprises learning means operative during the patient'"'"'s non-awakening period for generating and storing reference signals representative of the patient'"'"'s depolarization and repolarization waves during said non-awakening period, and current means for obtaining current signals representative of said depolarization and repolarization signals during said awakening period.

3. The system as described in claim 2, wherein said learning means comprises template means for obtaining and storing reference depolarization and repolarization templates, and said current means comprises current template means for cyclically obtaining and storing current depolarization and repolarization templates.

4. The system as described in claim 3, wherein said depolarization means comprises first comparison means for comparing the current depolarization template with said reference depolarization template to obtain a depolarization deviation value, and said repolarization means comprises second comparison means for comparing the current repolarization template with said reference repolarization template to obtain a repolarization deviation value.

5. The system as described in claim 4, wherein said depolarization means comprises first weighting means for weighting said depolarization deviation value as a function of depolarization wave stability to obtain said first measure, and said repolarization means comprises second weighting means for weighting said repolarization deviation value as a function of repolarization wave stability to obtain said second measure.

6. The system as described in claim 1, further comprising VES means for obtaining data representative of each patient ventricular extra systole and its criticality with respect to the ventricular vulnerable period.

7. The system as described in claim 1, wherein said VT prevention means further comprises means operative during said awakening period for accumulating weighted data representative of depolarization dispersion and repolarization dispersion.

8. A cardiac pacemaker system for pacing a patient, having VP means for generating and delivering ventricular pacing pulses to a patient'"'"'s ventricle, VS means for sensing ventricular QRS and T waves, rate means for determining the patient'"'"'s spontaneous heart rate, and control means for controlling when said VP means generates and delivers ventricular pacing pulses and the pacing rate of such pulses, wherein said control means further comprises VT prevention means for controlling said VP means to deliver pacing pulses at a rate overriding the patient'"'"'s spontaneous rate when a threshold of refractory dispersion is detected during patient awakening, said VT prevention means comprising:

awakening means for determining an awakening period when the patient is awakening;

dispersion data means for determining during said awakening period data representative of ventricular refractory dispersion;

threshold means for determining from said data when patient refractory dispersion exceeds said threshold; and

overdrive control means for setting pacing rate at an intervention rate which is adjusted as a function of said data.

9. The system as described in claim 8, wherein said dispersion data means comprises first means for obtaining data representative of a first predetermined parameter of the QRS-T wave signals and second means for obtaining data representative of a second predetermined parameter of the QRS-T wave signals.

10. A pacemaker system for pacing a patient'"'"'s heart, having VP means for generating and delivering pacing pulses to a patient'"'"'s ventricle, rate control means for controlling the rate of said pacing pulses, and said rate control means having VT prevention means for controlling said rate to an intervention rate when said patient has a detected measure of refractory dispersion during awakening, said VT prevention means comprising:

awakening means for determining when said patient is in a state of awakening;

dispersion means for determining a measure of dispersion of ventricular refractoriness; and

intervention means for setting and continually adjusting said intervention rate as a function of said dispersion measure.

11. The system as described in claim 10, wherein said dispersion means comprises means for cyclically obtaining a measure of the variability of the patient'"'"'s QRS during the awakening state.

12. The system as described in claim 10, wherein said dispersion means comprises means for obtaining a reference measure of the patient'"'"'s QRS waveforn when the patient is not awakening, means for obtaining a current measure of the patient'"'"'s current QRS waveform during awakening, and comparing means for comparing said current measure with said reference measure.

13. The system as described in claim 10, wherein said dispersion means comprises means for cyclically obtaining a measure of the variability of the patient'"'"'s T wave during the awakening state.

14. The system as described in claim 10, wherein said dispersion means comprises means for obtaining a reference measure of the patient'"'"'s T wave when the patient is not awakening, means for obtaining a current measure of the patient'"'"'s current T wave during awakening, and comparing means for comparing said current measure with said reference measure.

15. The system as described in claim 10, wherein said dispersion means comprises QT means for cyclically obtaining a measure of the variability of the patient'"'"'s QT interval during the awakening state.

16. The system as described in claim 10, further comprising VES means for detecting when a ventricular extra systole occurs during the awakening state that is close to the end of the ventricular refractory period, and wherein said intervention means comprises determining means for determining said intervention rate as a function of said VES detecting.

17. The system as described in claim 10, wherein said dispersion means comprises means for obtaining at least two respective measures of said dispersion, and accumulating means for accumulating said measures, and wherein said intervention means adjusts said intervention rate as a function of said accumulated measures.

18. The system as described in claim 10, comprising rate means for determining the patient'"'"'s spontaneous rate, and wherein said VT prevention means comprises means for setting said intervention right higher than said spontaneous rate, whereby said pacemaker overdrives the patient'"'"'s spontaneous rate during said awakening state.

19. The system as described in claim 17, wherein said intervention means comprises increment means for incrementing said intervention rate when said accumulated measures increase, and for decrementing said intervention rate when said accumulated measures decrease.

20. The system as described in claim 10, wherein said dispersion means comprises data means for cyclically obtaining data representative of ventricular refractoriness.