Small scale NMR spectroscopic apparatus and method

• US 6,163,154 A
• Filed: 12/23/1997
• Issued: 12/19/2000
• Est. Priority Date: 12/23/1997
• Status: Expired due to Fees

• Current Assignee: American Biotechnology Workgroup, Inc.
• Original Assignee: Magnetic Diagnostic Incorporated
• Inventors: John, Boban K., Shoolery, James N., Anderson, Marvin H., Schleich, Thomas W.
• Primary Examiner(s): Oda, Christine K.
• Assistant Examiner(s): Fetzner, Tiffany A.
• Application Number:
  US08/997,072
• Time in Patent Office: 1,092 Days
• Field of Search: 324/320, 324/318, 324/319
• US Class Current: 324/320
• CPC Class Codes: G01R 33/383 using permanent magnets

Abstract

A magnet assembly for a small scale NMR spectroscopy apparatus suitable for laboratory or home use, generally comprising two permanent magnets facing one another so that the facing surfaces have opposite polarities, a pole cap on each of the two facing surfaces of the permanent magnets, and a plurality of radially polarized canceling magnets disposed about the permanent magnets and pole caps. The design and position of the radially polarized canceling magnets about the tapered pole caps reduces leakage of the magnetic field, to maintain the magnetic field strength and homogeneity within the test region, without a disadvantageous increase in the size, weight and cost of the NMR apparatus. A curved edge ring shim may be used to increase magnetic field homogeneity in the test region. Also provided is a method for measurement of glucose concentration in a fluid using NMR spectroscopy. In one aspect of the invention the fluid is a patient'"'"'s body fluid and the invention provides for in vivo measurement of the glucose concentration. The method comprises spectral editing in which a RF pulse sequence is used to isolate desired resonances of glucose and thereby facilitate resolution of the glucose signal.

Claims

1. A magnet assembly for providing a substantially homogeneous magnetic field within a test region for an NMR apparatus, comprising:

a) a pair of opposed permanent magnets, each magnet having a back surface, a front surface facing the opposing permanent magnet front surface and one or more side surfaces between the front and back surfaces;

b) a pair of opposed pole cap members, each pole cap member having a back surface adjacent the front surface of one of the permanent magnets and having a front surface defining at least in part the test region between the pole cap members and facing the opposing pole cap member front surface and each pole cap member having a radially tapered side surface extending from the back surface toward the front surface, of the pole cap member of the pole cap member,

c) a plurality of annular canceling magnets, the canceling magnets encircling the side surfaces of the permanent magnets and the pole cap members, and being radially polarized; and

d) a pair of opposed annular ring shims, each annular ring shim encircling at least in part the side surface of a pole cap member adjacent the front surface of the pole cap member, each annular ring shim having a length from a front surface to a back surface of the ring shim which is less than a length of the pole cap member from the front surface to the back surface of the pole cap member.

2. The magnet assembly of claim 1 wherein a magnetic field of 1.4 Tesla is produced in the test region between the pole cap front surfaces, and the magnet assembly has a weight of not greater than about 62 kilograms.

3. The magnet assembly of claim 2 wherein the permanent magnets are about 15.5 cm to about 17 cm in diameter.

4. The magnet assembly of claim 2 wherein the permanent magnets are about 2.4 cm to about 2.6 cm in width.

5. The magnet assembly of claim 3 including a pair of yoke members extending beyond the permanent magnets and having a thickness of about 1.4 cm to about 2.0 cm, each yoke member having a front surface adjacent the back surface of one of the permanent magnets.

6. The magnet assembly of claim 5 including a housing having a thickness of about 0.2 cm to about 0.5 cm, the housing including a port providing access to the test region between the pole caps.

7. The magnet assembly of claim 6 wherein the magnet assembly has outside square dimensions of about 30 cm to about 50 cm and a length of about 25 cm to about 40 cm.

8. The magnet assembly of claim 1 wherein the canceling magnets have a thickness from the inner to the outer surface of about 6.5 to about 9.0 mm.

9. The magnet assembly of claim 1 wherein the canceling magnets have a thickness that increases toward a front surface of the canceling magnet facing the test region.

10. The magnet assembly of claim 1 wherein the ring shim has a surface in contact with a surface of the pole cap member.

11. The magnet assembly of claim 1 wherein the ring shim extends from behind the pole cap member front surface to a location spaced in front of the pole cap member front surface.

12. The magnet assembly of claim 1 wherein the ring shim is disposed in an annular groove in a peripheral portion of the pole cap front surface at a junction between the front surface of the pole cap member and the tapered side surfaces of the pole cap member.

13. The magnet assembly of claim 1 wherein the ring shim has a rectangular cross section.

14. The magnet assembly of claim 1 wherein an outer side of the ring shim is directed away from a surface of the pole cap member and is tapered.

15. The magnet assembly of claim 14 wherein a front edge of the ring shim tapered outer side is curved so that magnetic field homogeneity in the test region is increased.

16. The magnet assembly of claim 15 wherein a front edge of an inner side of the ring shim is curved so that magnetic field homogeneity in the test region is increased.

17. The magnet assembly of claim 6 including a back plate member between the yoke member and the permanent magnet.

18. The magnet assembly of claim 1 wherein the permanent magnets are a neodymium-iron-boron alloy.

19. The magnet assembly of claim 1 wherein the pole caps are iron.

20. The magnet assembly of claim 1 having at least 3 canceling magnets disposed about each pole cap, 1 canceling magnet disposed about each permanent magnet, and 1 canceling magnet disposed about the interface of each pole cap and permanent magnet.

21. The magnet assembly of claim 1 wherein at least a section of a canceling magnet is radially aligned with the ring shim.

22. The magnet assembly of claim 1 wherein the ring shims are a ferromagnetic material.

23. The magnet assembly of claim 1 having a plurality of canceling magnets longitudinally displaced from adjacent canceling magnets along a length of each pole cap member.

24. The magnet assembly of claim 23 wherein the canceling magnets have an inner surface at least a section of which is spaced away from a surface of the pole cap member.

25. The magnet assembly of claim 1 wherein the canceling magnets are a neodymium-iron-boron alloy.

26. The magnet assembly of claim 17 wherein the back plate member has a thickness of about 0.2 to about 0.5 cm.

27. The magnet assembly of claim 5 wherein the yoke member has a centrally tapering back surface.

28. A magnet assembly for providing a substantially homogeneous magnetic field within a test region for an NMR apparatus, comprising:

a) a pair of opposed permanent magnets, each magnet having a back surface, a front surface facing the opposing permanent magnet front surface and a side surface extending between the back and front surfaces;

b) a pair of opposed pole cap members, each pole cap member having a back surface adjacent the front surface of one of the permanent magnets and a front surface that defines at least in part a test region between the pole cap members that faces the opposing pole cap member front surface, and each pole cap member having radially tapered side surfaces extending from the back surface of the pole cap member toward the front surface of the pole cap member; and

c) a plurality of annular canceling magnets encircling the side surface of the pole cap member, which are adjacent to and longitudinally displaced from one another, and at least one annular canceling magnet encircling the side surfaces of the pole cap member and the permanent magnet at a junction therebetween, which has a height from an inner surface to an outer surface greater than a height of the canceling magnets encircling the pole cap member, and at least one annular canceling magnet encircling the side surface of the permanent magnet which has a height from an inner surface to an outer surface less than the height of the canceling magnets encircling around the pole cap member.

29. A NMR apparatus for measurement of a constituent concentration in a patient, comprising:

a) a magnet assembly for providing a substantially homogeneous magnetic field within a test region, comprising

a pair of opposed permanent magnets, each magnet having a back surface, a front surface facing the opposing permanent magnet front surface and one or more side surfaces disposed between the front and back surfaces;

a pair of opposed pole cap members, each pole cap member having a back surface adjacent the front surface of one of the permanent magnets, a front surface facing the opposing pole cap member front surface, and a radially tapered side surface extending from the back surface of the pole cap member toward the front surface of the pole cap member; and

a plurality of annular canceling magnets encircling the side surfaces of the permanent magnets and pole cap members and being radially polarized;

b) a pair of opposed annular ring shims, each annular ring shim encircling at least in part the side surface of a pole cap member adjacent the front surface of the pole cap member, each annular ring shim having a length from a front surface to a back surface of the ring shim which is less than a length of the pole cap member from the front surface to the back surface of the pole cap member;

c) a coil; and

d) a test region defined at least in part by said pole caps and said coil.