Biocompatible compositions and methods of using same

• US 6,165,486 A
• Filed: 11/19/1998
• Issued: 12/26/2000
• Est. Priority Date: 11/19/1998
• Status: Expired due to Term

• Current Assignee: Carnegie Mellon University, University Of Pittsburgh (University of Pittsburgh of The Commonwealth System of Higher Education)
• Original Assignee: Carnegie Mellon University, University Of Pittsburgh (University of Pittsburgh of The Commonwealth System of Higher Education)
• Inventors: Kumta, Prashant N., Weiss, Lee E., Calvert, Jay Wynn, Marra, Kacey G.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): GHALI, ISIS A D
• Application Number:
  US09/196,288
• Time in Patent Office: 768 Days
• Field of Search: 424/423, 424/425, 606/230, 128/90
• US Class Current: 424/423
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

Blends of biodegradable polymers, preferably poly(caprolactone) and poly(D,L-lactic-co-glycolic) acid are discussed as well as their applications in the medical field, particularly with regard to bone tissue engineering. Preferably, hydroxyapatite ("HA") granules are incorporated into the blends and the resulting blends have desirable mechanical, physical, and biological characteristics. Even more preferably the compositions of the present invention are utilized to form osteoconductive composites that supported bone cell growth on the surface as well as throughout the scaffold.

Claims

1. A composition comprised of:

a bioceramic material;

a polycaprolactone; and

a copolymer of poly(lactic) acid and poly(glycolic) acid;

said copolymer and said polycaprolactone blended at a predetermined ratio, said predetermined ratio being in the range of from about 10;

90 polycaprolactone to copolymer to about 50;

50 polycaprolactone to copolymer.

2. The composition of claim 1 wherein said composition is suitable as a bone substitute.

3. The composition of claim 1, further comprising a therapeutic agent.

4. The composition of claim 1 wherein said bioceramic material is a hydroxyapatite.

8. The composition of claim 1, wherein said copolymer is at a ratio of about 65:

35 lactic acid;

glycolic acid.

5. A method of treating a patient for a boney defect comprising the steps of:

mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone;

copolymer in the range of about 10;

90 to about 50;

50;

adding a bioceramic material to said blend;

molding said blend and said bioceramic into an implant; and

implanting said implant into said patient.

6. The method of claim 5, wherein said implant is selected from the group consisting of a bone prosthesis, a hard tissue implant, and a bone scaffold.

7. The method of claim 5, wherein said bioceramic is hydroxyapatite.

9. The method of claim 5, wherein said implant is osteoconductive.

12. The method of claim 5, wherein said implant is a prosthetic template.

13. The method of claim 5, wherein said implant is a template for bone formation.

14. The method of claim 5, wherein said copolymer is at a ratio of about 65:

35 lactic acid;

glycolic acid.

10. A method of treating a patient for a cranio-facial defect comprising the steps of:

mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone;

copolymer in the range of about 10;

90 to about 50;

50;

adding a bioceramic material to said blend;

molding said blend and said bioceramic into an implant; and

implanting said implant into said patient.

15. The method of claim 10, wherein said copolymer is at a ratio of about 65:

35 lactic acid;

glycolic acid.

11. A method of treating a patient in need of a bone substitute comprising the steps of:

mixing a polycaprolactone and a copolymer of poly(lactic) acid and poly(glycolic)acid to form a blend having a ratio of polycaprolactone;

copolymer in the range of about 10;

90 to about 50;

50;

adding a bioceramic material to said blend;

molding said blend and said bioceramic into an implant; and

implanting said implant into said patient.

16. The method of claim 11, wherein said copolymer is at a ratio of about 65:

35 lactic acid;

glycolic acid.