Method of controlling release of caffeine in chewing gum

• US 6,165,516 A
• Filed: 05/27/1999
• Issued: 12/26/2000
• Est. Priority Date: 11/27/1996
• Status: Expired due to Term

• Current Assignee: WM Wrigley Jr Company (Mars Incorporated)
• Original Assignee: WM Wrigley Jr Company (Mars Incorporated)
• Inventors: Reed, Michael A., Russell, Michael P., Tyrpin, Henry T., Witkewitz, David L., Schnell, Philip G., Gudas, Victor V.
• Primary Examiner(s): Corbin, Arthur L.
• Application Number:
  US09/308,972
• Time in Patent Office: 579 Days
• Field of Search: 426/3, 426/5, 426/6, 424/48
• US Class Current: 426/3
• CPC Class Codes: A23G 4/025 for coating or surface-finishing
• CPC Class Codes: A23G 4/06 characterised by the composition containing organic or inorganic compounds
• CPC Class Codes: A23G 4/064 containing inorganic compounds
• CPC Class Codes: A23G 4/068 containing plants or parts thereof, e.g. fruits, seeds, extracts containing gums A23G4/10
• CPC Class Codes: A23G 4/10 characterised by the carbohydrates used, e.g. polysaccharides containing dairy products A23G4/16
• CPC Class Codes: A23G 4/126 containing vitamins, antibiotics
• CPC Class Codes: A23G 4/20 Composite products, e.g. centre-filled , multi-layer, laminated
• CPC Class Codes: A23L 27/86 Addition of bitterness inhibitors
• CPC Class Codes: A61K 9/0058 Chewing gums non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00
• CPC Class Codes: A61K 9/2086 Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat active cores with a complete drug-free outer coat A61K9/28
• CPC Class Codes: A61K 9/209 containing drug in at least two layers or in the core and in at least one outer layer

Abstract

A method for producing a chewing gum with a controlled release of caffeine, as well as the chewing gum so produced, is obtained by physically modifying caffeine'"'"'s properties by coating and drying. Caffeine is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated caffeine is then co-dried and particle sized to produce a release-modified caffeine. When incorporated into the chewing gum, these particles are adapted to produce a fast release or a delayed release when the gum is chewed.

Claims

1. A method of producing a chewing gum containing physically-modified caffeine in order to increase the release rate of the caffeine comprising the steps of:

a) mixing a quantity of caffeine with an encapsulating agent to form a physically-modified caffeine having an increased release rate; and

b) adding a quantity of the physically-modified caffeine to a chewing gum formulation to provide a caffeine level in the gum of from about 0.2% to about 5%.

2. The method of claim 1 wherein the caffeine and encapsulating agent are also mixed with a solvent and the resulting mixture is dried prior to being added to the chewing gum.

3. The method of claim 2 wherein the encapsulating material is selected from the group consisting of maltodextrin and gum arabic.

4. The method of claim 2 wherein the mixture is spray dried and the solvent comprises water.

5. The method of claim 2 wherein a high-potency sweetener selected from the group consisting of aspartame, alitame, salts of acesulfame, cyclamate and its salts, saccharine and its salts, thaumatin, monellin, dihydrochalcones and combinations thereof is mixed in the mixture in combination with the caffeine.

6. A chewing gum made according to the method of claim 2.

7. A method of producing a chewing gum containing physically-modified caffeine in order to increase the release rate of caffeine comprising the steps of:

a) mixing a quantity of caffeine with an agglomerating agent and a solvent to partially coat the caffeine;

b) removing the solvent from the mixture of caffeine and agglomerating agent to form a dried material having an increased rate of release of the caffeine; and

c) adding a quantity of the dried material to a chewing gum formulation to provide a caffeine level in the gum of from about 0.2% to about 5%.

8. The method of claim 7 wherein the level of coating on the agglomerated caffeine is at least about 5%.

9. The method of claim 7 wherein the level of coating on the agglomerated caffeine is at least about 15%.

10. The method of claim 7 wherein the level of coating on the agglomerated caffeine is at least about 20%.

11. The method of claim 7 wherein the dried material is ground to a powder prior to adding the dried material to the chewing gum.