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Method for identifying apoptosis modulating compounds

  • US 6,165,732 A
  • Filed: 07/31/1998
  • Issued: 12/26/2000
  • Est. Priority Date: 10/14/1997
  • Status: Expired due to Term
First Claim
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1. A method for identifying apoptosis-modulating compounds which comprises:

  • (a) providing a lipid bilayer that includes a K+ - or an Cl- -selective channel wherein the covel comprises anti-apoptotic or pro-apoptotic polypeptide of the BCL-2 family, respectively, or fragment thereof which is capable of forming an ion selective channel in vitro;

    (b) contacting a compound of interest with the bilayer; and

    (c) determining ion-selectivity of the channelwherein a change from K+ -selective to Cl- -selective indicates the compound is a death agonist and a change from Cl- -selective to K+ -selective indicates the compound is a death antagonist.

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