Antisense modulation of nucleolin expression
First Claim
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1. An antisense compound 8 to 30 nucleobases in length targeted to nucleobases 1-97 of a 5'"'"' untranslated region;
- nucleobases 2287-2401 of a 3'"'"' untranslated region;
nucleobases 96-116 of a start codon region;
nucleobases 2222-2242 of a stop codon region;
or nucleobases 160-1923 of a coding region of human Nucleolin (SEQ ID NO;
3), wherein said antisense compound specifically hybridizes with and inhibits the expression of human Nucleolin.
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Abstract
Antisense compounds, compositions and methods are provided for inhibiting the expression of Nucleolin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Nucleolin. Methods of using these compounds for modulation of Nucleolin expression and for treatment of diseases associated with expression of Nucleolin are provided.
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Citations
23 Claims
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1. An antisense compound 8 to 30 nucleobases in length targeted to nucleobases 1-97 of a 5'"'"' untranslated region;
- nucleobases 2287-2401 of a 3'"'"' untranslated region;
nucleobases 96-116 of a start codon region;
nucleobases 2222-2242 of a stop codon region;
or nucleobases 160-1923 of a coding region of human Nucleolin (SEQ ID NO;
3), wherein said antisense compound specifically hybridizes with and inhibits the expression of human Nucleolin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- nucleobases 2287-2401 of a 3'"'"' untranslated region;
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14. An antisense compound up to 30 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 10, 12, 13, 14, 15, 19, 23, 25, 26, 27, 28, 29, 32, 34, 35, 37, 38, 39, 40, 41, 42, 45, 46, 47, 49, 50, 51, 54, 55, 56, 57, 59, 61, 62, 63, 65, 66, 67, 68, 69, 70, 71, 72, 73, 75, 76, 77, 78, 79, 80, 81, 82, 84, 85, 87, 88 or 89 which inhibits the expression of human Nucleolin.
- View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23)
Specification