Method for performing magnetic resonance angiography using a contrast agent

• US 6,167,293 A
• Filed: 04/19/1996
• Issued: 12/26/2000
• Est. Priority Date: 04/19/1996
• Status: Expired due to Term

• Current Assignee: General Electric Company, Martin R. Prince
• Original Assignee: General Electric Company, Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Prince, Martin R., Foo, Thomas Kwok-Fah, Chenevert, Thomas Leonard
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US08/635,078
• Time in Patent Office: 1,712 Days
• Field of Search: 128/653.4, 128/653.3, 128/653.2, 128/716, 128/721, 324/306, 324/309, 424/9.3, 600/410, 600/419, 600/420, 600/529, 600/534
• US Class Current: 600/420
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging

Abstract

A 3DFT MRA dynamic study is performed using a contrast agent to enhance image contrast. A monitor pulse sequence is performed at a high temporal rate to monitor the magnitude of the NMR signal produced in a monitor region after the contrast agent is injected into the patient. When the monitor signal reaches a threshold value, the patient is signaled and the 3DFT image data set is acquired.

Claims

1. A method for producing an image with NMR data acquired from a region of interest in a patient placed in an MRI system, the steps comprising:

a) injecting a contrast agent into the patient;

b) producing a monitor signal by repeatedly acquiring NMR data from a monitor region in the patient using a monitor pulse sequence in the MRI system;

c) detecting the flow of contrast agent into the region of interest by monitoring the value of the monitor signal;

d) acquiring NMR image data from the region of interest using a series of image pulse sequences in the MRI system when the flow of contrast agent into the region of interest is detected; and

e) reconstructing an image using the acquired NMR image data.

2. The method as recited in claim 1 in which step d) is performed after the monitor signal exceeds a specified threshold value.

3. The method as recited in claim 1 which includes signaling the patient prior to performing step d) to enable the patient to begin a breath-hold prior to the acquisition of NMR image data.

4. The method as recited in claim 3 in which the patient is signaled when the monitor signal exceeds a specified threshold value.

5. The method as recited in claim 1 in which the monitor pulse sequence employs one magnetic field gradient to select a first slab of spins for excitation by an RF pulse, and it employs a second read out magnetic field gradient during the acquisition of the NMR data.

6. The method as recited in claim 5 in which a third magnetic field gradient is employed in the monitor pulse sequence to select a second slab of spins which intersects the first slab of spins.

7. The method as recited in claim 6 in which a third magnetic field gradient is employed in the monitor pulse sequence to select a second slab of spins which intersects the first slab of spins.

8. The method as recited in claim 1 in which the image pulse sequence is a 3DFT pulse sequence and the NMR image data depicts a three-dimensional volume in the region of interest.

9. The method as recited in claim 1 in which the value of the monitor signal is determined by averaging a plurality of NMR data acquisitions from the monitor region.

10. The method as recited in claim 1 in which the value of the monitor signal is determined by integrating an NMR signal acquired by the monitor pulse sequence.

11. The method as recited in claim 1 in which the monitor region is within the region of interest from which the NMR image data is acquired.

12. The method as recited in claim 1 in which at least a portion of the monitor region is outside the region of interest from which the NMR image data is acquired.

13. The method as recited in claim 1 in which step c) is performed by:

measuring a baseline value of the monitor signal by acquiring NMR data from the monitor region prior to injecting the contrast agent using the monitor pulse sequence;

establishing a threshold value of the monitor value of the monitor signal relative to said baseline value of the monitor signal; and

determining that contrast agent is flowing into the region of interest when the monitor signal value exceeds the threshold value.

14. The method as recited in claim 13 in which the baseline value of the monitor signal is measured by acquiring NMR data from the monitor region during a plurality of patient respiratory cycles.

15. The method as recited in claim 13 in which the threshold value is a preset deviation from the baseline value.

16. A method for producing an image with NMR data acquired from a region of interest in a patient placed in an MRI system, the steps comprising:

a) injecting a contrast agent into the patient;

b) producing a monitor signal by repeatedly acquiring NMR data from a monitor region in the patient using a monitor pulse sequence in the MRI system;

c) detecting the flow of contrast agent into the region of interest by monitoring the value of the monitor signal;

d) acquiring NMR image data from the region of interest using a series of image pulse sequences in the MRI system when the flow of contrast agent into the region of interest is detected;

e) reconstructing an image using the acquired NMR image data; and

in which the mean value of the monitor signal is calculated and step (d) is performed after the value of the monitor signal exceeds a selected number of standard deviations from its calculated mean value.

17. The method as recited in claim 16 which includes signaling the patient prior to performing step d) to enable the patient to begin a breath-hold prior to the acquisition of NMR image data.

18. The method as recited in claim 17 in which the patient is signaled when the monitor signal exceeds a specified threshold value.

19. The method as recited in claim 16 in which the monitor pulse sequence employs one magnetic field gradient to select a first slab of spins for excitation by an RF pulse, and it employs a second read out magnetic field gradient during the acquisition of the NMR data.

20. The method as recited in claim 16 in which the image pulse sequence is a 3DFT pulse sequence and the NMR image data depicts a three-dimensional volume in the region of interest.

21. The method as recited in claim 16 in which the value of the monitor signal is determined by averaging a plurality of NMR data acquisitions from the monitor region.

22. The method as recited in claim 16 in which the value of the monitor signal is determined by integrating an NMR signal acquired by the monitor pulse sequence.

23. The method as recited in claim 16 in which the monitor region is within the region of interest from which the NMR image data is acquired.

24. The method as recited in claim 16 in which at least a portion of the monitor region is outside the region of interest from which the NMR image data is acquired.