Electric mammograph

• US 6,167,300 A
• Filed: 03/08/1999
• Issued: 12/26/2000
• Est. Priority Date: 03/08/1999
• Status: Expired due to Fees

• Current Assignee: TCI CO., LTD
• Original Assignee: TCI CO., LTD
• Inventors: Cherepenin, Vladimir Alexeevich, Korjenevsky, Alexandr Vladimirovich
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US09/264,594
• Time in Patent Office: 659 Days
• Field of Search: 600/547, 128/920, 324/600, 324/713, 324/717
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics

Abstract

The electric mammograph is an electrical impedance tomograph device for obtaining three-dimensional images of the conductivity distribution in biological tissues. A planar array of electrodes is put in contact with the tissues of interest. An AC source is connected to a single remotely attached electrode and to one of the planar array electrodes. Potential differences between the at rest electrodes in the planar array and a second remote at rest electrode are measured. The images are reconstructed using a modified back projection method.

Claims

1. A method of constructing a three-dimensional conductivity distribution for a biological tissue mass, said method comprising the steps of:

(a) applying a source of alternating current (AC) to a first activated electrode of a compact set of electrodes arranged in a planar array, said compact set of electrodes being in contact with the surface of said biological tissue mass, and to a single remotely located active electrode in contact with said biological tissue mass but at some distance from said compact set of electrodes, thereby setting up an electric field in said biological tissue;

(b) measuring a potential difference between a first inactive (at rest) electrode of said compact set and a single remotely located inactive electrode, said single remote inactive electrode being remotely located with respect to both said compact set of electrodes and said single remote active electrode;

(c) switching said AC source to activate successively all of the electrodes of said compact set of electrodes except said inactive electrode of step (b) and measuring a potential difference between said inactive electrode in (b) and said single remote inactive electrode for each activated electrode in turn to thereby obtain a first set of potential difference measurements for each successively activated electrode in said compact set of electrodes;

(d) switching the electrode to be measured in said compact set of electrodes to a second inactive electrode;

(e) switching said AC source to activate successively every other electrode in said compact set of electrodes, and measuring a potential difference between said second inactive electrode and said single remote inactive electrode in turn to thereby obtain a second set of potential difference measurements for each activated electrode;

(f) continue switching the inactive electrode in said compact set of electrodes as in steps (d) and (e), activating successively the remaining electrodes in said compact set of electrodes, and measuring the potential difference between the selected inactive electrode and said single inactive remote electrode in turn until all combinations of said compact set of electrodes have been measured; and

(g) reconstructing a three-dimensional conductivity distribution of said biological tissue mass using a back projection calculation method.

2. The method of claim 1, including measuring an output voltage of said AC source for each combination of active electrodes to determine whether any particular electrode of said planar array had sufficient contact with said biological tissue to give a meaningful measurement.

3. The method of claim 2, including calculating the values of potential differences for those electrodes having insufficient contact with said biological tissue mass based on the assumption of a homogeneous conductivity distribution rather than using the actual measured potential differences.

4. The method of claim 1, including using the weighting coefficient of 1/R⁴ in the back projection calculation of step (g), where R is the distance between a point where conductivity is being reconstructed and a current point on a line along which averaging is being carried out.

5. An apparatus for producing a three-dimensional image of the conductivity distribution in a biological tissue mass, said apparatus comprising:

a) a plurality of individual electrodes disposed in a rigid planar array and adapted to be placed in contact with said biological tissue mass, said planar array having one active electrode at any given time, the remaining electrodes being inactive;

b) a single remote active electrode located at some distance from said planar array and adapted to be placed in contact with said biological tissue mass;

c) a single remote inactive electrode located at some distance from said planar array and from said single remote active electrode and adapted to be placed in contact with said biological tissue mass;

d) an alternating current (AC) source connected to one of the electrodes (active electrode) in said planar array, thereby making it an active electrode, and continuously connected to said single remote active electrode;

e) an output multiplexer to successively switch said AC source to other electrodes in said planar array making them active electrodes in turn;

f) means to measure a potential difference between the inactive electrodes in said planar array and said single inactive remote electrode;

g) an input multiplexer to successively switch said means for measuring said potential difference between said inactive electrodes in said planar array and said single remote inactive electrode;

h) means coupled to said input and output multiplexers for sequencing said AC source through said planar array electrodes while taking potential difference measurements;

i) means for recording said potential difference measurements;

j) means for calculating and reconstructing a three-dimensional conductivity distribution of said biological tissue mass; and

k) means for displaying an image of said three-dimensional conductivity distribution.

6. The apparatus of claim 5, further including a means for determining whether any particular electrode of said planar array has sufficient contact with said biological tissue to give a meaningful measurement.

7. The apparatus of claim 5, wherein said planar array of electrodes is arranged on a rigid dielectric plane and the conducting portion of each electrode protrudes from said plane.