Method of treating psychological disorders by brain stimulation within the thalamus

• US 6,167,311 A
• Filed: 06/14/1999
• Issued: 12/26/2000
• Est. Priority Date: 06/14/1999
• Status: Expired due to Term

• Current Assignee: Electrocore Technologies LLC
• Original Assignee: Electrocore Technologies LLC
• Inventors: Rezai, Ali R.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US09/332,806
• Time in Patent Office: 561 Days
• Field of Search: 607/45, 600/378, 600/544
• US Class Current: 607/45
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36096 Mood disorders, e.g. depression, anxiety or panic disorder
• CPC Class Codes: A61N 1/36153 Voltage A61N1/3616 takes precedence
• CPC Class Codes: A61N 1/36167 Timing, e.g. stimulation onset

Abstract

A method for treating psychological disorders such as obsessive compulsive disorder, Tourette'"'"'s syndrome, depression, bipolar disorder, panic attacks, schizophrenia, and attention deficit disorder by stimulation of the thalamus, and in particular regions within the anterior and intralaminar nuclei of the thalamus. The method includes the steps of determining a common group of patients, each suffering from a common specific diagnosis for a psychological disorder; determining which common region of the patients'"'"' thalami are involved in carrying the pathological electrical signals which may otherwise be generated in dissimilar and disparate regions of the brains of the patients; surgically implanting an electrode and electrical signal generating device such that the electrode is positioned within the region of the thalamus identified as the common nexus; and selectively adjusting the level of electrical stimulation in accordance with the specific effect of the stimulation of the patient. In particular, the regions of the thalamus most frequently associated with psychological disorders are the anterior and intralaminar nuclei.

Claims

1. A method of therapeutically treating a psychological disorder by means of an implanted electrode coupled to an electrical signal source comprising the steps of:

surgically implanting said electrode in a brain of a patient so that a distal end thereof lies in communication with a predetermined treatment site in the thalamus of the brain, said predetermined site being selected from the group consisting of the anterior and intralaminar nuclei;

coupling a proximal end of said electrode to said electrical signal source; and

operating said electrical signal source to stimulate said predetermined treatment site in the thalamus of the brain, whereby the effects of psychological disorder are reduced.

2. The method as set forth in claim 1, wherein said stimulation increases thalamic activity.

3. The method as set forth in claim 1, wherein said stimulation decreases thalamic activity.

4. The method as set forth in claim 1, wherein said step of operating said electrical signal source comprises the step of operating said electrical signal source in a high frequency range of 50 to 2500 Hz.

5. The method as set forth in claim 1, wherein said step of operating said electrical signal source comprises the stepof operating said elctrical signal source in a low frequency range of 2 to 100 Hz.

6. The method as set forth in claim 1, wherein the stimulation is applied as a monopolar stimukation.

7. The method as set forth in claim 1, wherein the stimulation is applied as a bipolar stimulation.

8. The method as set forth in claim 1, wherein the stimulation is applied as a multipolar stimulation.

9. The method as set forth in claim 1, wherein said step of operating said electrical signal source comprises the step of operating said electrical signal source with a pulse width of selected from the range of 50 to 500 microseconds.

10. The method as set forth in claim 1, wherein said step of operating said electrical signal source comprises the step of operating said electrical signal source with a voltage selected from the range of 0.1 to 20 volts.

11. The method as set forth in claim 1, wherein said psychological disorder is selected from the group consisting of Tourette'"'"'s syndrome, obsessive compulsive disorder, depression, bipolar disorder, panic attacks, schizophrenia, and attention deficit disorder.

12. A method of therapeutically treating a psychological disorder by means of an implanted electrode coupled to an electrical signal source comprising the steps of:

identifying a specific psychological disorder exhibited by a patient;

surgically implanting said electrode in the brain of said patient so that a distal end thereof lies in communication with a predetermined treatment site in the thalamus of the brain, which predetermined treatment site is in correspondence with the common site exhibiting pathological electrical activity across a large sampling of patients exhibiting said specific psychological disorder, said predetermined site being selected from the group consisting of the the anterior and intralaminar nuclei;

coupling a proximal end of said electrode to said electrical signal source; and

operating said electrical signal source to stimulate said predetermined treatment site in the thalamus of the brain, whereby the effects of psychological disorder are reduced.

13. The method as set forth in claim 12, wherein said stimulation increases thalamic activity.

14. The method as set forth in claim 12, wherein said stimulation decreases thalamic activity.

15. The method as set forth in claim 12, wherein said step of operating said electrical signal source comprises the step of operating said electrical signal source in a high frequency range of 50 to 2500 Hz.

16. The method as set forth in claim 12, wherein said step of operating said electrical signal source comprises the stepof operating said elctrical signal source in a low frequency range of 2 to 100 Hz.

17. The method as set forth in claim 12, wherein the stimulation is applied as a monopolar stimukation.

18. The method as set forth in claim 12, wherein the stimulation is applied as a bipolar stimulation.

19. The method as set forth in claim 12, wherein the stimulation is applied as a multipolar stimulation.

20. The method as set forth in claim 12, wherein said step of operating said electrical signal source comprises the step of operating said electrical signal source with a pulse width of selected from the range of 50 to 500 microseconds.

21. The method as set forth in claim 12, wherein said step of operating said electrical signal source comprises the step of operating said electrical signal source with a voltage selected from the range of 0.1 to 20 volts.

22. The method as set forth in claim 12, wherein said psychological disorder is selected from the group consisting of Tourette'"'"'s syndrome, obsessive compulsive disorder, depression, bipolar disorder, panic attacks, schizophrenia, and attention deficit disorder.

23. A method of determining the proper therapeutic treatment for, and subsequently treating a specific psychological disorder by means of an implanted electrode coupled to an electrical signal source comprising the steps of:

identifying a large sampling of patients, each exhibiting a common specific psychological disorder;

identifying which common region of the thalamus exhibits pathological electrical activity during manifestations of the specific psychological disorder, said common region thereafter constituting a predetermined treatment site;

surgically implanting said electrode in the brain of each of said patients so that a distal end thereof lies in communication with the predetermined treatment site in the thalamus of the brain, said predetermined site being selected from the group consisting of the anterior and intralaminar nuclei;

coupling a proximal end of said electrode to said electrical signal source; and

operating said electrical signal source to stimulate said predetermined treatment site in the thalamus of the brain, whereby the effects of psychological disorder are reduced.

24. The method as set forth in claim 23, wherein said stimulation increases thalamic activity.

25. The method as set forth in claim 23, wherein said stimulation decreases thalamic activity.

26. The method as set forth in claim 23, wherein said psychological disorder is selected from the group consisting of Tourette'"'"'s syndrome, obsessive compulsive disorder, depression, bipolar disorder, panic attacks, schizophrenia, and attention deficit disorder.

27. A method of determining the proper therapeutic treatment for a specific psychological disorder comprising the steps of:

identifying a large sampling of patients, each exhibiting a common specific psychological disorder; and

identifying which common region of the thalamus exhibits pathological electrical activity during manifestations of the specific psychological disorder, said common region thereafter constituting a predetermined treatment site, whereafter a suitable means for affecting the activity of said predetermined treatment site may be employed.

28. The method as set forth in claim 27, wherein the common regions of the thalamus constituting the predetermined treatment site is selected from the group consisting of the anterior and intralaminar nuclei.

29. The method as set forth in claim 27, wherein saidpsychological disorder is selected from the group consisting of Tourette'"'"'s syndrome, obsessive compulsive disorder, depression, bipolar disorder, panic attacks, schizophrenia, and attention deficit disorder.