Targeted hysteresis hyperthermia as a method for treating diseased tissue
First Claim
1. A method for site specific treatment of diseased tissue in a patient, comprising the steps of:
- (i) delivering a magnetic material which has a magnetic heating efficiency of at least about 4.5×
10-8 J.m./A.g. when magnetic field conditions are equal to or less than about 7.5×
107 A/s to diseased tissue in a patient; and
(ii) exposing the magnetic material in the patient to a linear alternating magnetic field with a frequency of greater than about 10 kHz and a field strength such that the product of field strength, frequency, and the radius of the exposed region is less than about 7.5×
107 A/s to generate hysteresis heat in the diseased tissue.
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Accused Products
Abstract
A method for site specific treatment of diseased tissue in a patient, comprising the steps of: (i) selecting at least a magnetic material which has a magnetic heating efficiency of at least about 4.5×10-8 J.m./A.g, when magnetic field conditions are equal to or less than about 7.5×107 A/s; (ii) delivering the magnetic material to diseased tissue in a patient; and (iii) exposing the magnetic material in the patient to a linear alternating magnetic field with a frequency of greater than about 10 kHz and a field strength such that the product of field strength, frequency and the radius of the exposed region is less than about 7.5×107 A/s to generate hysteresis heat in the diseased tissue.
120 Citations
45 Claims
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1. A method for site specific treatment of diseased tissue in a patient, comprising the steps of:
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(i) delivering a magnetic material which has a magnetic heating efficiency of at least about 4.5×
10-8 J.m./A.g. when magnetic field conditions are equal to or less than about 7.5×
107 A/s to diseased tissue in a patient; and(ii) exposing the magnetic material in the patient to a linear alternating magnetic field with a frequency of greater than about 10 kHz and a field strength such that the product of field strength, frequency, and the radius of the exposed region is less than about 7.5×
107 A/s to generate hysteresis heat in the diseased tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A method for generating hysteresis heat in a tissue, comprising:
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delivering to the tissue magnetic material having a magnetic heating efficiency of at least about 4.5×
10-8 J.m./A.g., when the magnetic field conditions are about 7.5×
107 A/s or less; andexposing the tissue, containing the delivered magnetic material, to a linear alternating magnetic field with a frequency of about 10 kHz or greater and a field strength such that the product of field strength, frequency, and the radius of the exposed tissue is less than about 7.5×
107 A/s to generate hysteresis heat in the tissue. - View Dependent Claims (37, 38)
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39. A method for the treatment of cancerous growth or tumors, comprising:
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delivering to a tissue containing a cancerous growth or tumor, a magnetic material having a magnetic heating efficiency of at least about 4.5×
10-8 J.m./A.g., when the magnetic field conditions are about 7.5×
107 A/s or less; andexposing the tissue, containing the delivered magnetic material, to a linear alternating magnetic field with a frequency of about 10 kHz or greater and a field strength such that the product of field strength, frequency, and the radius of the exposed tissue is less than about 7.5×
10e7 A/s to generate hysteresis heat in the tissue.
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40. A method for the heat treatment of a target tissue in a patient, comprising the steps of:
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administering to the patient'"'"'s tissue magnetic material having a magnetic heating efficiency of at least about 4.5×
10-8 J.m./A.g., when the magnetic field conditions are about 7.5×
107 A/s or less; andselectively exposing the tissue to a linear alternating magnetic field with a frequency of about 10 kHz or greater and a field strength such that the product of field strength, frequency, and the radius of the exposed tissue is less than about 7.5×
10e7 A/s to generate hysteresis heat in the tissue. - View Dependent Claims (41, 42, 43, 44, 45)
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Specification