×

Di-aryl ethers and their derivatives as anti-cancer agents

  • US 6,169,104 B1
  • Filed: 03/25/1998
  • Issued: 01/02/2001
  • Est. Priority Date: 03/26/1997
  • Status: Expired due to Term
First Claim
Patent Images

1. A method of inhibiting the growth of a tumor cell, said method comprising contacting said tumor cell with a compound having the structure:

  • or a pharmaceutically acceptable salt thereof;

    wherein;

    X, if present, is a member selected from the group consisting of A, together with the carbons to which it is bound, forms an optionally substituted 3, 4, 5 or 6 membered carbocylic or heterocyclic ring;

    R9 and R10 are members independently selected from the group consisting of hydrogen, alkyl and halogen;

    Y is a member selected from the group consisting of H, alkyl and alkoxy;

    Z is a member selected from the group consisting of Q is a member selected from the group consisting of H, alkyl and S-alkyl;

    R1, R2, R3 and R4 are members independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, hydroxyl, alkoxy, halogen, nitro and amino; and

    R5, R6, R7 and R8 are members independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, hydroxyl, alkoxy and halogen;

    with the proviso that if Z is and Q is methyl, then Y is other than methoxy and ethoxy.

View all claims
  • 4 Assignments
Timeline View
Assignment View
    ×
    ×