Sesamol inhibition of Δ-5-desaturase activity and uses therefor

• US 6,172,106 B1
• Filed: 10/28/1999
• Issued: 01/09/2001
• Est. Priority Date: 02/09/1998
• Status: Expired due to Term

• Current Assignee: Barry D. Sears
• Original Assignee: Forse R. Armour, Sambasiva R. Chavali
• Inventors: Forse, R. Armour, Chavali, Sambasiva R.
• Primary Examiner(s): Spivack, Phyllis G.
• Application Number:
  US09/429,420
• Time in Patent Office: 439 Days
• Field of Search: 514/464
• US Class Current: 514/464
• CPC Class Codes: A61K 31/36 Compounds containing methylenedioxyphenyl groups, e.g. sesamin

Abstract

Methods for inhibiting Δ-5-desaturase activity, for inhibiting arachidonic acid metabolism, for inhibiting PGE₂ levels and for inhibiting PLA₂ activity comprising administering sesamol are disclosed.

Claims

1. A method of inhibiting Δ

-5-desaturase activity in a mammal comprising administering to the mammal a composition comprising an effective amount of sesamol.

2. A method of inhibiting arachidonic acid metabolism in a mammal comprising administering to the mammal a composition comprising an effective amount of sesamol.

3. A method of inhibiting the level of PGE₂ in a mammal comprising administering to the mammal a composition comprising an effective amount of sesamol.

4. A method of inhibiting the activity of PLA₂ in a mammal comprising administering to the mammal a composition comprising an effective amount of sesamol.

5. A method of reducing IL-6 levels in a mammal comprising administering to the mammal a composition comprising an effective amount of sesamol.