Patched antibodies

• US 6,172,200 B1
• Filed: 10/20/1997
• Issued: 01/09/2001
• Est. Priority Date: 10/07/1994
• Status: Expired due to Term

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Inventors: Johnson, Ronald L., Goodrich, Lisa V., Scott, Matthew P.
• Primary Examiner(s): Kemmerer, Elizabeth
• Assistant Examiner(s): Brannock, Michael T.
• Application Number:
  US08/954,668
• Time in Patent Office: 1,177 Days
• Field of Search: 530/388.22, 530/350, 530/388.1
• US Class Current: 530/388.22
• CPC Class Codes: A01K 2217/05 Animals comprising random inserted nucleic acids (transgenic)
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/43563 from insects
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: C07K 14/705 Receptors; Cell surface antigens; Cell surface determinants tumour specific antigens C07K14/4748

Abstract

Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. The patched genes permit production of patched protein and production of antibodies that bind to patched proteins. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.

Claims

1. A monoclonal antibody that specifically binds to a naturally occurring patched protein, other than a Drosophila patched protein.