Production of enantiomer-free biarylketocarboxylic acids
First Claim
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1. Process for the preparation of enantiomerically pure biarylketocarboxylic acids, characterized in that the auxiliary base used in the resolution is S-phenylethyl-amine.
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Abstract
The invention relates to a continuous process for the preparation of enantiomerically pure biarylketocarboxylic acids, S-phenylethylamine being employed as an auxiliary base in the resolution. Biarylketocarboxylic acids, in particular substituted biaryl-4-ketocarboxylic acids, are inhibitors of enzymes of the matrix metalloproteinases class. By inhibition of the abovementioned enzymes, it is possible, for example, to control osteoarthritis, rheumatoid arthritis and metastases.
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1 Claim
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1. Process for the preparation of enantiomerically pure biarylketocarboxylic acids, characterized in that the auxiliary base used in the resolution is S-phenylethyl-amine.
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