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Transdermal pressure sensitive adhesive drug delivery system

  • US 6,174,546 B1
  • Filed: 05/01/2000
  • Issued: 01/16/2001
  • Est. Priority Date: 02/21/1997
  • Status: Expired due to Fees
First Claim
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1. A pressure sensitive adhesive drug delivery composition for use in the transdermal administration of a pharmacologically active agent comprised of a homogeneous admixture of a hydrophilic macromer reinforced copolymer and a pharmacologically active agent, said copolymer comprising the crosslinked reaction product of:

  • (1) at least one A monomer consisting of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol, said alcohol having from 1 to 30 carbon atoms, wherein at least about 30 percent by weight of said A monomer consists of a monomeric (meth)acrylic acid ester of a non-tertiary alcohol having at least 12 carbon atoms, and said at least one A monomer exhibiting an average number of carbon atoms in the alcohol portion of the total (meth)acrylic acid esters of at least 10, (2) optionally at least one B monomer, (3) optionally a polymeric graft moiety C having a Tg greater than 20°

    C., and (4) a graft macromer D containing hydrophilic repeat units.

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