Cardiovascular information measurement system

• US 6,176,832 B1
• Filed: 08/27/1998
• Issued: 01/23/2001
• Est. Priority Date: 09/01/1997
• Status: Expired due to Term

• Current Assignee: Terumo Kabushiki Kaisha (Terumo Corporation)
• Original Assignee: Terumo Kabushiki Kaisha (Terumo Corporation)
• Inventors: Habu, Yoshiyuki, Yaegashi, Mitsutoshi
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US09/141,263
• Time in Patent Office: 880 Days
• Field of Search: 600/485, 600/490, 600/493-6, 600/500, 600/503, 600/504, 600/505, 600/465
• US Class Current: 600/485
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00

Abstract

It is an object of the present invention to provide a cardiovascular information measurement system capable of performing an accurate blood pressure measurement and calculating an accurate cardiovascular index in consideration of the pulsation of a blood vessel wall. To achieve this object, the cardiovascular information measurement system includes ultrasonic transducer groups (4a, 4b) for simultaneously detecting sectional shapes (3a, 3b) of two arterial portions, a cross-sectional area calculation unit (5) for calculating cross-sectional areas of the two arterial portions on the basis of the detected sectional shapes, a flow velocity calculation unit (6) for calculating an average blood flow velocity in an artery on the basis of the cross-sectional areas calculated by the cross-sectional area calculation unit (5), a pulse wave velocity calculation unit (7) for calculating a pulse wave propagation velocity between the two arterial portions in accordance with time changes in the detected sectional shapes of the two arterial portions, a relative blood pressure calculation unit (8) for calculating a relative blood pressure value to a reference blood pressure value obtained in a specific time phase, on the basis of the calculated blood flow velocity and the calculated pulse wave propagation velocity, and an absolute blood pressure calculation unit (10) for calculating an absolute blood pressure value on the basis of the relative blood pressure value and the reference blood pressure value obtained in the specific time phase and measured in advance.

Claims

1. A cardiovascular information measurement system characterized by comprising:

sectional shape detection means for simultaneously detecting sectional shapes of at least two arterial portions;

cross-sectional area calculation means for calculating cross-sectional areas of the two arterial portions on the basis of the sectional shapes detected by said sectional shape detection means;

flow velocity calculation means for calculating an average blood flow velocity in an artery on the basis of the cross-sectional areas calculated by said cross-sectional area calculation means;

pulse wave velocity calculation means for calculating a pulse wave propagation velocity between the two arterial portions in accordance with time changes in the sectional shapes of the two arterial portions which are detected by said sectional shape detection means;

relative blood pressure calculation means for calculating a relative blood pressure value to a reference blood pressure value obtained in a specific time phase, on the basis of the blood flow velocity calculated by said flow velocity calculation means and the pulse wave velocity calculated by said pulse wave velocity calculation means; and

absolute blood pressure calculation means for calculating an absolute blood pressure value on the basis of the relative blood pressure value and the reference blood pressure value obtained in the specific time phase and measured in advance.

2. The system according to claim 1, characterized in that said flow velocity calculation means calculates an average blood flow velocity of a portion surrounded by the two arterial portions and a blood vessel wall in accordance with the cross-sectional areas of the two arterial portions, their time differential values, and a distance between the sections of the two arterial portions.

3. The system according to claim 1, characterized in that said sectional shape detection means comprises ultrasonic emission means for emitting an ultrasonic wave toward the artery, ultrasonic detection means for detecting an ultrasonic wave reflected in a living body, and binarization means for binarizing an output signal from said ultrasonic detection means using an appropriate threshold value as a reference in order to extract the sectional shape of the arterial wall.

4. The system according to claim 3, characterized in that said binarization means comprises threshold value correction means for correcting the threshold value by vasodilation and vasoconstriction.

5. The system according to claim 3, characterized in that said binarization means comprises means for detecting a position right above the center of the artery.

6. The system according to claim 3, characterized in that said ultrasonic emission means and said ultrasonic detection means comprise a plurality of ultrasonic emission means and a plurality of ultrasonic detection means, and said system further comprises pulse wave velocity measurement means for measuring a pulse wave propagation velocity in accordance with a phase difference of changes in sectional shapes of a plurality of arterial walls which are obtained by said plurality of ultrasonic detection means.

7. The system according to claim 3, characterized in that said sectional shape detection means further comprises conversion means for converting an output from said ultrasonic detection means into an image signal.

8. The system according to claim 7, characterized in that said binarization means binarizes the converted image signal using an appropriate image density value as a threshold value after said conversion means converts the output signal from said ultrasonic detection means into the image signal.

9. The system according to claim 3, characterized in that said binarization means comprises setting means for setting the threshold value in accordance with an angle formed between an ultrasonic incident direction and the arterial wall.

10. The system according to claim 9, characterized in that said binarization means further comprises arithmetic means for calculating an angle between an ultrasonic wave incident direction and the arterial wall on the basis of the cross-sectional area detected by said sectional shape detection means and the ultrasonic wave incident direction.

11. A cardiovascular information measurement system characterized by comprising:

ultrasonic emission means for emitting an ultrasonic wave toward a blood vessel;

ultrasonic wave detection means for detecting an ultrasonic wave reflected in a living body;

binarization means for setting an appropriate threshold value in accordance with an angle between an incident direction of the ultrasonic wave and a blood vessel wall and binarizing an output signal from said ultrasonic detection means; and

index calculation means for calculating a cardiovascular index on the basis of blood vessel sectional shape information obtained from information binarized by said binarization means.

12. The system according to claim 11, characterized in that said binarization means comprises threshold value correction means for correcting the threshold value by vasodilation and vasoconstriction.

13. The system according to claim 11, characterized in that said binarization means comprises means for detecting a position right above the center of the blood vessel.

14. The system according to claim 13, characterized in that said means for detecting the position right above the center of the blood vessel comprises a plurality of pressure-sensitive elements bought into contact with a skin surface near the position right above the blood vessel while crossing the blood vessel, and a processing unit for detecting the position right above the blood vessel in accordance with pulse waves detected by said pressure-sensitive elements.

15. The system according to claim 14, characterized in that said plurality of pressure-sensitive elements are arranged substantially parallel to a plurality of ultrasonic transducers constituting said ultrasonic detection means.

16. The system according to claim 11, characterized in that said ultrasonic emission means and said ultrasonic detection means comprise a plurality of ultrasonic emission means and a plurality of ultrasonic detection means, and said system further comprises pulse wave velocity measurement means for measuring a pulse wave propagation velocity in accordance with a phase difference of changes in sectional shapes of a plurality of blood vessel walls which are obtained by said plurality of ultrasonic detection means.

17. The system according to claim 11, characterized in that said index calculation means comprises pulse wave measurement means for measuring a pulse wave on the basis of a change in blood vessel diameter or section.

18. The system according to claim 11, characterized in that said index calculation means comprises displacement detection means for detecting a change in blood vessel diameter or section, pressure measurement means for detecting a pressure acting on the wall surface of the blood vessel, and dynamic property calculation means for calculating a dynamic viscoelasticity of the blood vessel on the basis of results obtained from said displacement detection means and said pressure measurement means.