Starburst conjugates

• US 6,177,414 B1
• Filed: 03/08/2000
• Issued: 01/23/2001
• Est. Priority Date: 08/18/1986
• Status: Expired due to Fees

• Current Assignee: Dendritic NanoTechnologies, Inc. (Loveland Products, Inc.)
• Original Assignee: The Dow Chemical Company (Dow, Inc.)
• Inventors: Fazio, Michael J., Hedstrand, David M., Cheng, Roberta C., Kaplan, Donald A., Kruper, William J., Tomlinson, Ian A., Tomalia, Donald A., Wilson, Larry R.
• Primary Examiner(s): Levy, Neil S.
• Application Number:
  US09/521,409
• Time in Patent Office: 321 Days
• Field of Search: 424/78.17-78.18, 424/78.36, 424/78.27, 424/78.31, 424/484, 424/486, 424/501, 514/159, 514/162-166, 514/722, 514/772.1, 514/772.3, 514/772.6, 514/788, 523/1, 521/25, 521/28, 521/29, 528/328, 528/332, 528/363
• US Class Current: 514/159
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A61K 47/59 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
• CPC Class Codes: A61K 47/6885 the conjugate or the polymer being a starburst, a dendrimer, a cascade
• CPC Class Codes: A61K 47/6949 inclusion complexes, e.g. clathrates, cavitates or fullerenes
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C07C 211/29 the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
• CPC Class Codes: C07C 233/11 with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
• CPC Class Codes: C07C 237/20 the carbon skeleton containing six-membered aromatic rings
• CPC Class Codes: C08G 73/02 Polyamines
• CPC Class Codes: C08G 83/003 Dendrimers
• CPC Class Codes: C08L 101/005 Dendritic macromolecules
• CPC Class Codes: C12N 15/87 Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
• CPC Class Codes: Y10S 424/16 Dendrimers and dendritic polymers

Abstract

Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.

Claims

1. A dense star conjugate which comprises a dendrimer polymer complexed with a carried material, the carried material being salicylic acid and the dedrimer polymer comprising a polyamidoamine.

2. A formulation which comprises a conjugate of claim 1 having at least one pharmaceutically acceptable diluent or carrier present.

3. A pharmaceutically acceptable composition comprising salicylic acid complexed to a branched polyamidoamine carrier, and a diluent.

4. The composition of claim 3 wherein the carrier molecule is complexed to the salicylic acid by ionic, covalent, or Van der Waals bonding.