Infrared endoscopic imaging in a liquid with suspended particles: method and apparatus

• US 6,178,346 B1
• Filed: 10/23/1998
• Issued: 01/23/2001
• Est. Priority Date: 10/23/1998
• Status: Expired due to Term

• Current Assignee: Olympus Corporation
• Original Assignee: David C. Amundson, Hanlin H. John
• Inventors: Amundson, David C., Hanlin, H. John
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): Shaw, Shawna J.
• Application Number:
  US09/178,566
• Time in Patent Office: 823 Days
• Field of Search: 600/473, 600/310, 600/342, 600/109, 600/160, 600/178, 600/478, 606/2-4, 606/15, 348/65, 348/67, 348/68, 348/77, 348/78, 356/39, 356/43, 356/51
• US Class Current: 600/473
• CPC Class Codes: A61B 1/00165 with light-conductive means, e.g. fibre optics A61B1/07 takes precedence
• CPC Class Codes: A61B 1/042 characterised by a proximal camera, e.g. a CCD camera
• CPC Class Codes: A61B 1/063 for monochromatic or narrow-band illumination
• CPC Class Codes: A61B 1/0669 at proximal end of an endoscope
• CPC Class Codes: A61B 1/07 using light-conductive means, e.g. optical fibres
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation

Abstract

A device and method for imaging an object that is situated within a fluid environment having suspended particles uses infrared illumination. In a representative application, a catheter having fiber optics is inserted into the vasculature of a patient. The fiber optics transmits infrared light to an optical head at a distal end of the catheter, which transmits the light into a bloody environment to an object to be imaged. Light reflecting from the object is collected and transmitted throughout the fiber optic to an infrared camera, so that an image is formed. Proper selection of the wavelength of infrared illumination allows objects to be imaged through what would otherwise be an opaque liquid. The invention has particular utility in the field of medical imaging.

Claims

1. A method of acquiring an image of a structure obscured in the visible wavelength-region by blood, comprising the steps of:

projecting monochromatic infrared illumination at a wavelength corresponding to a local absorption minima through the blood to the structure to be imaged, such that at least some of said infrared illumination is reflected or scattered by the structure;

collecting at least some of the reflected or scattered infrared illumination at the same wavelength; and

transmitting at least some of the collected scattered illumination to an infrared camera, whereby an image of the structure is formed.

2. The method of claim 1, wherein the projecting step includes inserting the infrared light source directly to a position proximate the structure.

3. The method of claim 2, wherein the projecting step includes projecting illumination through an air interface.

4. The method of claim 2, wherein the projecting step includes projecting illumination through a gel interface.

5. The method of claim 1, wherein the projecting step includes inserting a transmission line capable of transmitting infrared illumination to a position proximate the structure.

6. The method of claim 5, wherein the projecting step is accomplished using a transmission line which is a fiber optic cable.

7. The method of claim 5, wherein the projecting step includes inserting the transmission line into a body of a patient.

8. The method of claim 7, wherein the projecting step includes flexibly inserting the transmission line through the vascular system of a patient.

9. The method of claim 1, wherein the projecting step includes projecting illumination having a wavelength greater than 1.4 microns.

10. The method of claim 9, wherein the projecting step includes projecting illumination having a wavelength in a range selected from the group consisting of 1.4 to 1.8 microns, 2.1 to 2.4 microns, 3.7 to 4.3, 4.6 to 5.4, and 7 to 14 microns.

11. The method of claim 10, wherein the projecting step includes projecting illumination having a wavelength in a range selected from the group consisting of 1.4 to 1.8 microns, 2.1 to 2.4 microns and 3.7 to 4.3 microns.

12. The method of claim 11, wherein the projecting step includes projecting illumination having a wavelength in a range selected from the group consisting of 1.4 to 1.8 microns, and 2.1 to 2.4 microns.

13. The method of claim 1, wherein the collecting step utilizes a device positioned proximate an end of said transmission line for concentrating said infrared illumination.

14. The method of claim 13, wherein the collecting step is accomplished using a device which is a hood.

15. The method of claim 14, wherein the collecting step is accomplished using a hood which is flared.

16. The method of claim 1, wherein the projecting step includes transmitting infrared illumination along a first transmission line, and the transmitting step includes transmitting infrared illumination along a second transmission line separate from the first transmission line.

17. The method of claim 16, wherein the projecting step is accomplished such that the first transmission line and second transmission line are fiber optic cables.

18. The method of claim 16, wherein the projecting step is accomplished such that the second transmission line defines a core and the first transmission line is a bundle of fibers positioned around the core.

19. The method of claim 16, wherein the projecting step is accomplished such that the first transmission line and second transmission line are positioned along side each other in a half circular configuration.

20. The method of claim 1, wherein the transmitting step includes transmitting at least some scattered collected illumination through an optical relay lens engaged with the camera.

21. The method of claim 1, wherein the projecting step includes projecting infrared illumination through a fiber and thence through a fiber optic head, the fiber optic head directing illumination in a desired direction with respect to the structure.

22. The method of claim 1, wherein the projecting step includes projecting infrared illumination through a fiber and thence through a fiber optic head having an optical axis, the illumination passing through the optical axis at an angle other than parallel.

23. The method of claim 1, wherein the projecting step includes projecting infrared illumination through a fiber and thence through a fiber optic head, the fiber having a polished faceted end for concentrating said illumination in a desired direction.

24. The method of claim 1, wherein the projecting step and transmitting step are performed on a common transmission line.

25. The method of claim 24, wherein the projecting step and transmitting steps are accomplished using a common transmission line that includes fiber optic cables.

26. The method of claim 25, wherein the projecting step and transmitting step are performed using an optical beamsplitter.

27. The method of claim 1, wherein the projecting step includes projecting polarized illumination.

28. The method of claim 1, wherein the projecting step includes projecting pulsed light.

29. A device for imaging an object within a bloody liquid medium, the device comprising:

an endoscope catheter including a fiber optic cable suitable for transmitting infrared light, said fiber optic cable having a distal end and a proximal end;

an infrared light source engaged with the proximal end of said cable, said light source for transmitting monochromatic infrared light at a wavelength corresponding to a local absorption minima;

an optical head assembly engaged with the distal end of said cable for transmitting infrared illumination from the infrared light source through the bloody liquid medium to the object and for receiving reflected and scattered light from the object and transmitting said reflected light to said cable; and

a lens and an infrared camera for receiving said reflected and scattered light from said cable at the same wavelength and forming an image of said object.

30. The device of claim 29, wherein the infrared light source produces infrared illumination at a wavelength greater than 1.4 microns.

31. The device of claim 29, wherein the infrared light produces infrared illumination at a wavelength corresponding to a water absorption local minimum.

32. The device of claim 31, wherein the infrared light source produces infrared illumination in the wavelength regions consisting of 1.4 to 1.8 microns, 2.1 to 2.4 microns, 3.7 to 4.3, 4.6 to 5.4, and 7 to 14 microns.

33. The device of claim 32, wherein the infrared light source produces infrared illumination in the wavelength regions consisting of 1.4 to 1.8 microns, 2.1 to 2.4 microns and 3.7 to 4.3 microns.

34. The device of claim 33, wherein the infrared light source produces infrared illumination in the wavelength regions consisting of 1.4 to 1.8 microns and 2.1 to 2.4 microns.

35. The device of claim 29, further comprising an image processor and video processor engaged with the infrared camera for processing the image formed by said infrared camera.

36. The device of claim 29, further comprising a guide wire or stylet for guiding said endoscope catheter to a desired site.

37. The device of claim 29, further comprising a light focusing hood attached to said catheter proximate said optical head assembly.

38. The device of claim 29, wherein at least a portion of the optical head assembly is housed within a transparent window attached to the distal end of the fiber optic cable.

39. The device of claim 29, further comprising a beamsplitter so that the infrared illumination and the reflected and scattered light share a common optical path.

40. The device of claim 29, wherein the fiber optic cable includes illuminating fibers and imaging fibers separate from said illumination fibers;

the illuminating fibers being engaged with the light source and the optical head, for transmitting light between the light source and the optical head;

the imaging fibers being engaged with the infrared camera and the optical head, for transmitting light between the infrared camera and the optical head.

41. The device of claim 29, wherein the light source generates light having a wavelength of about 2.1 microns.

42. The device of claim 29, wherein the imaging fibers form a core and the illuminating fibers are arranged around said core.

43. The device of claim 29, wherein the infrared light source generates light having a wavelength of about four microns.

44. The device of claim 29, wherein the infrared light source generates polarized light.

45. The device of claim 29, wherein the infrared light source generates pulsed light in a flash configuration.

46. An imaging device comprising:

means for directing infrared illumination at a wavelength through blood so that at least some of the infrared illumination will reflect from an object within said blood, thereby generating reflected illumination;

said illumination being monochromatic and corresponding to a local absorption minima of the blood;

means for receiving said reflected illumination at the same wavelength; and

an infrared camera engaged with said receiving means capable of forming an image of the object.

47. A non-invasive method of imaging an object within a closed environment such as an eye that has a mixture of blood and vitreous humor, where the blood has rendered the object opaque in the visible spectrum comprising the steps of:

introducing monochromatic infrared illumination into the closed environment so that the infrared illumination is reflected and scattered by the environment;

said monochromatic infrared illumination being at a wavelength corresponding to a local absorption minima of the blood; and

receiving said reflected and scattered light at the same wavelength with an infrared camera to form an image of the object within the closed environment.

48. The method of claim 47, that uses infrared illumination wavelengths from 1.6 to 12 microns.

49. The method of claim 47, wherein the introducing step introduces infrared illumination through an air-media interface.

50. The method of claim 47, wherein the introducing step introduces the infrared illumination though an interface selected from the group consisting of liquid and gel.

51. The method of claim 47, wherein the introducing step introduces polarized infrared illumination.

52. The method of claim 51, wherein the introducing step introduces pulsed infrared illumination.

53. Apparatus for forming an image within a closed environment containing a liquid or gel wherein blood has rendered the closed environment opaque in the visible spectrum, comprising:

means for introducing infrared illumination into the closed environment, whereby the illumination is scattered and reflected;

means for collecting the scattered and reflected illumination to form an image of objects or surface details of the closed environment; and

whereby said means for introducing illumination introduces monochromatic illumination at a wavelength corresponding to a local absorption minima and the collecting means collects the scattered and reflected illumination at the same wavelength.

54. The apparatus of claim 53, wherein the introducing means introduces infrared illumination having a wavelength of from 1.6 to 12 microns.

55. The apparatus of claim 53, that uses a fixed focal length optical objective to introduce the infrared illumination into the environment, and receive the illumination exiting the environment.

56. The apparatus of claim 53, wherein at least one of the introducing means and collecting means includes a variable focal length or zoom lens.

57. The apparatus of claim 53, further comprising a beamsplitter engaged with the introducing means and the collecting means.

58. The apparatus of claim 53, further comprising a beamsplitter engaged with the introducing means such that the an illumination optical path and an imaging optical path share a common optical element.

59. The apparatus of claim 53, wherein the introducing means introduces illumination from a fiber optic element distributed around a circumference or to one side of an objective lens.

60. The apparatus of claim 53, further comprising a CPU engaged with the collecting means for enhancing the collected illumination.

61. The apparatus of claim 53, wherein the introduced illumination has an intensity and a duty cycle, and further comprising a CPU processing unit that controls the intensity and duty cycle of the introduced illumination.

62. The apparatus of claim 53, further comprising an ophthalmic repair or surgical laser that can be used to affect repairs or procedures of an eye.