Focussing of therapeutic radiation on internal structures of living bodies

• US 6,179,767 B1
• Filed: 02/01/1999
• Issued: 01/30/2001
• Est. Priority Date: 02/01/1999
• Status: Expired due to Term

• Current Assignee: International Business Machines Corporation
• Original Assignee: International Business Machines Corporation
• Inventors: Ziegler, James Francis, von Gutfeld, Robert Jacob
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US09/241,503
• Time in Patent Office: 729 Days
• Field of Search: 600/1, 600/424, 600/439, 600/461, 600/462
• US Class Current: 600/1
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61N 2005/1051 using an active marker markers in general A61B90/39
• CPC Class Codes: A61N 2005/1091 Kilovoltage or orthovoltage range photons
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam

Abstract

This invention helps achieve accurate focussing of therapeutic radiation at an internal structure (e.g. cancerous organ), which is often substantially movable within a living body. For this purpose, suitable sensors are laproscopically or surgically implanted at the location of the organ. These sensors may include semiconductor materials, scintillation materials, piezo-acoustic materials, x-ray emitters, or other materials which emit a signal when they are scanned by a beam of harmless investigative radiation, such as low intensity therapeutic radiation. The emitted signal is then monitored via implanted wires or light fibers or via external detectors during scanning to determine the targetted location at which a signal maximum occurs, whereupon the desired intensity of therapeutic radiation is focussed on this targetted location.

Claims

1. A method of therapeutic treatment of an internal structure of a living body with therapeutic radiation, said method comprising the steps of:

a) implanting, at said internal structure, a sensor to identify a selected location of said internal structure, said sensor being capable of emitting a signal in response to irradiation thereof by a beam of an investigative radiation,

b) scanning a region of said living body which includes said internal structure with a beam of said investigative radiation of a sufficiently low intensity to avoid causing injury to portions of said region that are adjacent to said internal structure,

c) measuring said signal to determine occurrence of a maximum intensity of said signal during scanning step (b),

d) associating said maximum intensity with a corresponding scanned location of said region, and

e) focussing a selected intensity of said therapeutic radiation at a target determined from said corresponding scanned location of said region.

2. A method as set forth in claim 1, wherein said investigative radiation comprises said therapeutic radiation.

3. A method as set forth in claim 2, wherein said sensor comprises a semiconductor diode capable of producing electric signals of an intensity that varies with the intensity of investigative radiation impinging upon said sensor during scanning of said region by said beam.

4. A method as set forth in claim 3, wherein said measuring step c) is carried out with wires implanted in said living body, said wires connecting said semiconductor diode to a location which is external to said living body.

5. A method as set forth in claim 2, wherein said sensor comprises a scintillator material capable of producing light signals of an intensity that varies with the intensity of investigative radiation impinging upon said sensor during scanning of said region by said beam, and wherein said measuring step c) is carried out with light-transmitting fibers connecting said sensor to a location which is external to said living body.

6. A method as set forth in claim 2, wherein said sensor comprises a piezoelectric material capable of producing acoustic signals of an intensity that varies with the intensity of investigative radiation impinging upon said sensor during scanning of said region by said beam, and wherein said measuring step c) is carried out with an acoustic microphone which is disposed external to said living body.

7. A method as set forth in claim 2, wherein said sensor comprises an x-ray emitting material capable of producing acoustic signals of an intensity that varies with the intensity of investigative radiation impinging upon said sensor during scanning of said region by said beam, and wherein said measuring step c) is carried out with an x-ray detector which is disposed external to said living body.

8. A system for therapeutic treatment of an internal structure of a living body with therapeutic radiation, said system comprising:

a) a sensor implanted to identify a selected location of said internal structure, said sensor being capable of emitting a signal in response to irradiation thereof by a beam of investigative radiation,

b) a beam projector for scanning a region of said living body which includes said internal structure with a beam of said investigative radiation of a sufficiently low intensity to avoid causing injury to portions of said region that are adjacent to said internal structure,

c) a signal measurement device for measuring said signal to determine occurrence of a maximum intensity of said signal during scanning of said region by said beam projector,

d) a computing apparatus for associating said maximum intensity with a corresponding scanned location of said region, and

e) a controlled source of therapeutic radiation for focussing a selected intensity of said therapeutic radiation at a target determined from said corresponding scanned location of said region.

9. A system as set forth in claim 8, wherein said investigative radiation comprises said therapeutic radiation.

10. A system as set forth in claim 9, wherein said sensor comprises a semiconductor diode capable of producing electric signals of an intensity that varies with the intensity of investigative radiation impinging upon said sensor during scanning of said region by said beam.

11. A system as set forth in claim 10, wherein said sensor comprises wires implanted in said living body, said wires connecting said semiconductor diode to said signal measurement device.

12. A system as set forth in claim 9, wherein said sensor comprises a scintillator material capable of producing light signals of an intensity that varies with the intensity of investigative radiation impinging upon said sensor during scanning of said region by said beam, and wherein said sensor comprises light-transmitting fibers connecting said scintillator material to said signal measurement device.

13. A method as set forth in claim 9, wherein said sensor comprises a piezoelectric material capable of producing acoustic signals of an intensity that varies with the intensity of investigative radiation impinging upon said sensor during scanning of said region by said beam, and wherein said signal measurement device comprises an acoustic microphone which is disposed external to said living body.

14. A method as set forth in claim 9, wherein said sensor comprises a piezoelectric material capable of producing electrical signals of an intensity that varies with the intensity of investigative radiation impinging upon said sensor during scanning of said region by said beam, and wherein said sensor comprises wires implanted in said living body, said wires connecting said piezoelectric material to said signal measurement device.

15. A system as set forth in claim 9, wherein said sensor comprises an x-ray emitting material capable of producing x-ray signals of an intensity that varies with the intensity of investigative radiation impinging upon said sensor during scanning of said region by said beam, and wherein said signal measurement device comprises an x-ray detector which is disposed external to said living body.