Biopolymer matt for use in tissue repair and reconstruction

• US 6,179,872 B1
• Filed: 03/17/1998
• Issued: 01/30/2001
• Est. Priority Date: 03/17/1998
• Status: Expired due to Fees

• Current Assignee: TEI Biosciences, Inc. (Integra LifeSciences Holdings Corporation)
• Original Assignee: Tissue Engineering, Inc. (Integra LifeSciences Holdings Corporation)
• Inventors: Sioussat, Tracy M., Begley, Michael J., Bell, Eugene
• Primary Examiner(s): Zirker, Daniel
• Application Number:
  US09/042,549
• Time in Patent Office: 1,050 Days
• Field of Search: 530/356, 530/354, 623/11, 623/16, 623/11.11, 442/123, 428/304.4
• US Class Current: 623/11.11
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/38 containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/60 Materials for use in artificial skin
• CPC Class Codes: Y10T 428/249953 Composite having voids in a component [e.g., porous, cellular, etc.]
• CPC Class Codes: Y10T 442/2525 Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Abstract

Biopolymer matt, biopolymer matt composites, biopolymer matt compositions, and methods of preparing the matt and composite matts are described. Also described are biocompatible constructs which include extracellular matrix macromolecules and methods of preparing these constructs. The matt, matt compositions and biocompatible constructs of the invention can be used in tissue repair and reconstruction.

Claims

1. A resorbable nonporous biopolymer matt comprising a densely packed random array of biopolymer fibrils.

2. The biopolymer matt of claim 1, wherein said biopolymer fibrils are selected from the group consisting of collagen, laminin, elastin, fibronectin, fibrinogen, thrombospondin, gelatin, polysaccharides, poly-1-amino acids and combinations thereof.

3. The biopolymer matt of claim 1, wherein said biopolymer fibrils are derived from collagen.

4. The biopolymer matt of claim 3, wherein said collagen is fetal porcine collagen.

5. The biopolymer matt of claim 1, wherein said biopolymer matt further comprises macromolecules necessary for cell growth, morphogenesis, differentiation, or tissue building and combinations thereof.

6. The biopolymer matt of claim 1, wherein the biopolymer fibrils are crosslinked.

7. The biopolymer matt of claim 1, further including a resorbable polymer selected from the group consisting of fibers, braids, bundles of fibers, fabrics and nonwoven fabrics.

8. The biopolymer matt of claim 1, wherein said biopolymer further includes pores.

9. The biopolymer matt of claim 1, wherein said matt is in or on a support.

10. The biopolymer matt of claim 9, wherein said support is porous.

11. The biopolymer matt of claim 10, wherein said biopolymer matt is bound to a single density biopolymer foam comprising a network of communicating microcompartments having biopolymer molecules and/or biopolymer filaments interspersed within the wall of the microcompartments, wherein the microcompartments:

have volume dimensions of x, y, and z, wherein x=length, y=width, and z=height, are substantially equal, and range from about 1 μ

m to about 300 μ

m; and

have an average wall thickness of less than about 10 μ

m.

12. The biopolymer matt of claim 11, wherein said biopolymer foam is derived from fetal porcine collagen.

13. The biopolymer matt of claim 1, wherein said biopolymer matt further comprises cells.