×

Tunable indocyanine dyes for biomedical applications

  • US 6,180,087 B1
  • Filed: 01/18/2000
  • Issued: 01/30/2001
  • Est. Priority Date: 01/18/2000
  • Status: Expired due to Fees
First Claim
Patent Images

1. A composition comprising indocyanine dyes of formula wherein a4 and b4 are independently from 0 to 5;

  • W4 and X4 are independently selected from the group consisting of C((CH2)zzOH)2 C((CH2)zzCO2H)2 C((CH2)zzNRppRpz)2; and

    zz is from 1 to 5;

    Rpp and Rpz are independently selected from the group consisting of —

    (CH2)c

    CO2H, —

    CH2

    (CH2

    O—

    CH2)d

    CH2

    CO2H, —

    (CH2)g

    N(R14)—

    (CH2)h

    CO2H, and —

    (CH2)i

    N(R15)—

    CH2

    (CH2

    O—

    CH2)i

    CH2

    CO2H;

    Y4 and Z4 are independently selected from the group consisting of —

    (CH2)c

    CO2H, —

    CH2

    (CH2

    O—

    CH2)d

    CH2

    CO2H, —

    (CH2)e

    NH2, —

    CH2

    (CH2

    O—

    CH2)f

    CH2

    NH2, —

    (CH2)g

    N(R14)—

    (CH2)h

    CO2H, and —

    (CH2)i

    N(R15)—

    CH2

    (CH2

    O—

    CH2)j

    CH2

    CO2H;

    A2 is a single or a double bond;

    if A2 is a single bond, then B2 is selected from the group consisting of —

    O—

    , —

    S—

    , —

    Se—

    , —

    P— and



    NR38 and D2 is CR42;

    if A2 is a double bond, then B2 is selected from the group consisting of —

    O—

    , —

    S—

    , —

    Se—

    , —

    P— and



    NR38, C2 is selected from nitrogen and —

    CR41 and D2is —

    CR42;

    R45 to R57 are independently selected from the group consisting of hydrogen, C1-C10 alkyl, hydroxyl, C1-C10 alkoxyl, cyano, nitro, halogen, and —

    NR43R44, R14, R15 and R38 to R42 are independently selected from the group consisting of -hydrogen, C1-C10 alkyl, C1-C10 alkoxyl, —

    CH2(CH2

    O—

    CH2)c

    CH2

    OH, —

    (CH2)d

    CO2H, —

    CH2

    (CH2

    O—

    CH2)e

    CH2

    CO2H, —

    (CH2)f

    NH2, and —

    CH2

    (CH2

    O—

    CH2)g

    CH2

    NH2;

    c, e, g, h, and i are independently from 1 to 10;

    d, f and j are independently from 1 to 100; and

    R43 and R44 are independently selected from the group consisting of hydrogen and C1-C10 alkyl, and a pharmaceutically acceptable carrier or excipient.

View all claims
  • 2 Assignments
Timeline View
Assignment View
    ×
    ×