Polyurethane-containing delivery systems

• US 6,180,129 B1
• Filed: 10/23/1997
• Issued: 01/30/2001
• Est. Priority Date: 12/13/1988
• Status: Expired due to Fees

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Magruder, Judy A., Peery, John R., Cortese, Richard, Eckenhoff, James B., Wright, Jeremy C.
• Primary Examiner(s): Levy, Neil S.
• Application Number:
  US08/956,424
• Time in Patent Office: 1,195 Days
• Field of Search: 424/422-424, 424/430-431, 424/433-438, 424/453-455, 424/473, 604/892.1, 604/890.1, 604/891.1
• US Class Current: 424/422
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.

Claims

1. A delivery system for delivering a beneficial agent to an environment of use, the delivery system comprising:

(a) a wall surrounding an internal lumen;

(b) said wall comprising two sections;

(1) a first section made of a composition that is impermeable to the passage of fluid and (2) a second section made of a polyurethane composition that permits the passage of fluid, said first and second sections joined in a fluid tight arrangement which wall sections form said internal lumen;

(c) a beneficial agent formulation in that portion of the internal lumen formed by the wall section that is impermeable to the passage of fluid;

(d) an osmotic composition for aiding in delivering the beneficial agent from the delivery system in the lumen formed by the wall section that permits the passage of fluid; and

(e) exit means in the wall connecting the exterior of the delivery system with the internal lumen for delivering the beneficial agent to the environment of use.

2. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the environment of use is an animal.

3. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is a hormone.

4. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the delivery system is an implant.

5. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the beneficial agent is sensitive to water and the delivery system substantially protects the beneficial agent from water.

6. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein said first and second wall portions each have an end and the end of one of said first and second wall portions is placed inside the end of the other of said first and second wall portions to form said internal lumen.