Chemical array fabrication with identifier

• US 6,180,351 B1
• Filed: 07/22/1999
• Issued: 01/30/2001
• Est. Priority Date: 07/22/1999
• Status: Expired due to Fees

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Agilent Technologies, Inc.
• Inventors: Cattell, Herbert F.
• Primary Examiner(s): Brusca, John S.
• Assistant Examiner(s): Kim, Young J.
• Application Number:
  US09/359,536
• Time in Patent Office: 558 Days
• Field of Search: 712/200, 707/200, 435/6, 435/287.2, 435/7.5, 901/6, 901/16
• US Class Current: 435/6.11
• CPC Class Codes: C12Q 1/6837 using probe arrays or probe chips C12Q1/6874 takes precedence
• CPC Class Codes: C40B 40/04 Libraries containing only organic compounds
• CPC Class Codes: C40B 50/16 involving encoding steps

Abstract

A method of generating an addressable array of biopolymers, such as DNA probes, on a substrate. The method includes receiving from a remote station, information on a layout of the array and an associated first identifier. A local identifier is generated corresponding to the first identifier and associated array, the local identifier being shorter in length than the corresponding first identifier. The addressable array is fabricated on the substrate in accordance with the received layout information. A first copy of the local identifier is applied to the substrate or a housing carrying the substrate. The fabricated array and the first copy of the local identifier are shipped to a remote user station. A method at the corresponding user station, and apparatus and computer program products useful at either station, are further provided.

Claims

1. A method of generating an addressable array of biopolymers on a substrate, comprising:

(a) receiving from a remote station, information on a layout of the array and an associated first identifier;

(b) generating a local identifier corresponding to the first identifier and associated array layout information, the local identifier being shorter in length than the corresponding first identifier;

(c) fabricating the addressable array on the substrate in accordance with the received layout information;

(d) applying a first copy of the local identifier to the substrate or a housing carrying the substrate;

(d) shipping the fabricated array and the first copy of the local identifier to a remote station; and

(e) forwarding a second copy of the corresponding local identifier to the remote station such that the local identifier is associated with the corresponding first identifier.

2. A method according to claim 1 wherein the first identifier is unique.

3. A method according to claim 1 wherein the biopolymers are polynucleotides.

4. A method according to claim 1 wherein the biopolymers are DNA.

5. A method according to claim 1 wherein the second copy of the local identifier is forwarded to the remote station in association with the corresponding first identifier.

6. A method according to claim 5 wherein the second copy of the local identifier is applied to a same medium to which the corresponding first identifier is applied.

7. A method according to claim 1 wherein the second copy of the local identifier is shipped to the remote station on or in the same package with the corresponding first identifier and the fabricated array.

8. A method according to claim 7 wherein the second copy of the local identifier and first identifier are present together on a packaging containing the fabricated array.

9. A method according to claim 1 wherein a second copy of the local identifier is communicated to the remote station.

10. A method according to claim 1 wherein the array and the first copy of the corresponding local identifier are shipped to the same remote station from which the corresponding first identifier and the layout information were received.

11. A method according to claim 1 wherein the array and the first copy of the corresponding local identifier are shipped to a remote station different from that from which the corresponding first identifier and the layout information were received.

12. A method according to claim 1, additionally comprising saving the received first identifiers in a memory each in association with the corresponding local identifier.

13. A method according to claim 12 additionally comprising saving array layout information for each array in a memory, in association with the corresponding local identifier.

14. A method of generating, at a central fabrication station, addressable arrays of biopolymers on multiple substrates, comprising:

(a) receiving from each of multiple remote stations, information on a layout of an array and an associated first identifier;

(b) for each received first identifier and associated array, generating a local identifier corresponding to the first identifier and associated array, the local identifier being shorter in length than the corresponding first identifier;

(c) fabricating an addressable array on the substrate in accordance with each received layout information;

(d) applying a first copy of each local identifier to the substrate or a housing carrying the substrate, which substrate carries the array corresponding to the generated local identifier;

(d) shipping each of the fabricated arrays and the first copy of the corresponding local identifier to one or more of the remote stations; and

(e) forwarding a second copy of each corresponding local identifier to a remote station such that the local identifier is associated with the corresponding first identifier.

15. A method according to claim 14 wherein the first identifier is unique.

16. A method according to claim 14 additionally comprising applying a second copy of each local identifier and corresponding first identifier to a same medium, and shipping the medium and corresponding array to the same remote station from which the corresponding first identifier was received.

17. A method according to claim 14 wherein a second copy of each local identifier is communicated to the remote station from which the corresponding first identifier was received.

18. A method according to claim 14, additionally comprising at the central fabrication station, saving received first identifiers in a memory each in association with the corresponding local identifiers.

19. A method according to claim 18 additionally comprising saving array layout information for each array in a memory in association with the corresponding local and first identifiers.

20. A computer program product, comprising:

a computer readable storage medium having a computer program stored thereon for performing, when loaded into a computer communicating with a fabricator to fabricate an addressable array on the substrate, the steps of;

(a) receiving from a remote station, information on a layout of the array and an associated first identifier;

(b) generating a local identifier corresponding to the first identifier and associated array, the local identifier being shorter in length than the corresponding first identifier;

(c) controlling fabrication of the addressable array on the substrate in accordance with the received layout information;

(d) applying a first copy of the local identifier to the substrate or a housing carrying the substrate; and

(e) generating a second copy of the corresponding local identifier and forwarding the second copy to the remote station such that the local identifier is associated with the corresponding first identifier.

21. A computer program product according to claim 20 wherein the second copy is forwarded to the remote station by communication to the remote station.

22. A computer program product according to claim 20 wherein the second copy is forwarded by writing to a same medium as the corresponding first identifier for shipping to the remote station.