Antisense inhibition of tumor necrosis factor alpha converting enzyme (TACE) expression
First Claim
Patent Images
1. An antisense compound 8 to 30 nucleobases in length targeted to nucleotides 2911 through 2930, nucleotides 2641 through 2660 or nucleotides 2681 through 2700 of a 3′
- -untranslated region, nucleotides 2770 through 2603 of a stop codon region, nucleotides 131 through 150, nucleotides 2471 through 2490 or nucleotides 2531 through 2570 of a coding region, or nucleotides 114 through 133 of an AUG codon region of human TNF-α
converting enzyme SEQ ID NO;
1, wherein said antisense compound inhibits expression of human TNF-α
converting enzyme.
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Abstract
Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-α-converting enzyme (TACE). Antisense oligonucleotides targeted to nucleic acids encoding TACE are preferred. Methods of using these oligonucleotides for inhibition of TACE expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TACE or TNF-α are provided.
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Citations
14 Claims
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1. An antisense compound 8 to 30 nucleobases in length targeted to nucleotides 2911 through 2930, nucleotides 2641 through 2660 or nucleotides 2681 through 2700 of a 3′
- -untranslated region, nucleotides 2770 through 2603 of a stop codon region, nucleotides 131 through 150, nucleotides 2471 through 2490 or nucleotides 2531 through 2570 of a coding region, or nucleotides 114 through 133 of an AUG codon region of human TNF-α
converting enzyme SEQ ID NO;
1, wherein said antisense compound inhibits expression of human TNF-α
converting enzyme. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- -untranslated region, nucleotides 2770 through 2603 of a stop codon region, nucleotides 131 through 150, nucleotides 2471 through 2490 or nucleotides 2531 through 2570 of a coding region, or nucleotides 114 through 133 of an AUG codon region of human TNF-α
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14. An antisense compound up to 30 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 2, SEQ ID NO;
3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, SEQ ID NO;
7, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, or SEQ ID NO;
12 which inhibits the expression of human TNF-α
converting enzyme.
- 2, SEQ ID NO;
Specification