Breath test for detection of drug metabolism
First Claim
1. A method for measuring a characteristic of metabolism of a drug of therapeutic value to a subject and determining a therapeutically effective dosage of said drug for said subject, the characteristic of metabolism being selected from a group consisting of a rate of metabolism and an extent of metabolism, the method comprising the steps of:
- (a) administering said drug labeled with an isotope to said subject, such that said drug is an administered drug;
(b) analyzing exhaled breath of the subject for a concentration of said isotope, said concentration of said isotope directly indicating the characteristic of metabolism of said administered drug in the subject and (C) employing said characteristic of metabolism to determine a therapeutically effective dosage of said drug for said subject.
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Abstract
A breath test for determining the rate of metabolism of a drug is described. First, a safe and effective amount of the drug, preferably appropriately labelled and most preferably isotopically-labelled, is administered to a subject. After a suitable time period, the exhaled breath of the subject is analyzed to determine the concentration of a metabolite. The concentration of the metabolite is then used to determine the rate of metabolism of the drug. A breath test kit is also described. Such a breath test kit would include an item or items necessary for performing at least one of the methods of determining the rate of metabolism of a drug in a subject. For example, such a breath test kit could include an isotopically-labelled drug to be administered to the subject.
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Citations
27 Claims
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1. A method for measuring a characteristic of metabolism of a drug of therapeutic value to a subject and determining a therapeutically effective dosage of said drug for said subject, the characteristic of metabolism being selected from a group consisting of a rate of metabolism and an extent of metabolism, the method comprising the steps of:
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(a) administering said drug labeled with an isotope to said subject, such that said drug is an administered drug;
(b) analyzing exhaled breath of the subject for a concentration of said isotope, said concentration of said isotope directly indicating the characteristic of metabolism of said administered drug in the subject and (C) employing said characteristic of metabolism to determine a therapeutically effective dosage of said drug for said subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method for measuring a rate of metabolism of a drug of therapeutic value to a subject and determining a therapeutically effective dosages of said drug for said subject, comprising:
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(a) administering said drug labeled with an isotope to said subject, such that said drug is an administered drug;
(b) analyzing exhaled breath of the subject for a concentration of said isotope, said concentration of said isotope directly indicating the rate of metabolism of the administered drug in said subject and (c) employing said rate of metabolism to determine a therapeutically effective dosage of said drug for said subject. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
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Specification