Method for delivering a medication

• US 6,183,461 B1
• Filed: 09/14/1999
• Issued: 02/06/2001
• Est. Priority Date: 03/11/1998
• Status: Expired due to Fees

• Current Assignee: Solace Therapeutics, Inc.
• Original Assignee: Situs, Inc.
• Inventors: Matsuura, David G., Sirivong, Mikxay, Gillespie, Walter Dean, Zupkas, Paul F., Parsons, Charles Lowell, Greelis, John Patrick
• Primary Examiner(s): SEIDEL, RICHARD K
• Assistant Examiner(s): Blyveis, Deboah
• Application Number:
  US09/395,415
• Time in Patent Office: 511 Days
• Field of Search: 604/530-532, 604/890.1, 604/891.1, 604/93.01, 604/131, 604/132, 604/141, 604/134, 604/30, 604/19, 604/500, 604/502, 604/514, 604/517
• US Class Current: 604/502
• CPC Class Codes: A61M 2210/1085 Bladder
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/152 pressurised by contraction of elastic reservoirs containers for dispensing contents by contraction of an elastic bag provided therein, in general B65D83/0061

Abstract

A drug-infusing device is implanted into a body cavity such as a bladder. The device is implanted in an uninflated, low profile state. After insertion into the body cavity, the device is filled with a substance, such as a drug, and assumes an increased profile. After the device is filled, it is allowed to float freely within the body cavity. Alternatively, the device can be tethered to a wall of the body cavity. The device delivers the drug at a controlled rate over an extended period of time. In order to deliver the drug at a controlled rate, the device preferably has a pressure-responsive valving member. The flow resistance of the valving member is responsive to the pressure at which the drug is stored within the infusing device. The resistance of the valving member decreases as the pressure within the infusing device decreases, thereby providing a resultant controlled flow rate.

Claims

1. A method of dispensing medication within a body comprising:

implanting a substantially empty resilient reservoir having a generally elongated shape into the body;

transferring medication into the resilient reservoir while it is within the body, wherein the receipt of said medication causes the resilient member to assume a shape which is at least partially arcuate; and

dispensing medication from the reservoir into the body over a substantially controlled period of time.

2. The method of claim 1, wherein said medication is an incontinence-treating drug.

3. The method of claim 1, wherein said medication is used to treat urge incontinence.

4. The method of claim 1, wherein said medication is used to treat pain or neuralgia.

5. The method of claim 1, wherein said medication is an antibiotic.

6. The method of claim 1, wherein said medication is used to treat cystitis.

7. The method of claim 1, wherein said medication is an anti-cancer drug.

8. The method of claim 1, further comprising the step of removing the resilient reservoir from the bladder after said infusing step.

9. A method of dispensing medication within a body comprising:

implanting a substantially empty infusion device into the body, the infusion device configured to contain a medication and comprising an elastomeric portion which defines a substantially elongated shape when empty;

introducing medication into the infusion device;

expanding the elastomeric portion as medication is added to the infusion device;

constraining a portion of the elastomeric portion as said elastomeric portion expands such that the expanded elastomeric portion defines a nonlinear profile; and

dispensing medication from the infusion device into the body.

10. The method of claim 9, wherein said medication is an incontinence-treating drug.

11. The method of claim 9, wherein said medication is used to treat urge incontinence.

12. The method of claim 9, wherein said medication is used to treat pain or neuralgia.

13. The method of claim 9, wherein said medication is an antibiotic.

14. The method of claim 9, wherein said medication is used to treat cystitis.

15. The method of claim 9, wherein said medication is an anti-cancer drug.

16. The method of claim 9, further comprising the step of removing the infusion device from the bladder after said infusing step.