Carrier patch for the delivery of agents to the skin

• US 6,183,770 B1
• Filed: 04/15/1999
• Issued: 02/06/2001
• Est. Priority Date: 04/15/1999
• Status: Active Grant

• Current Assignee: Scapa Tapes North America Inc
• Original Assignee: Acutek International
• Inventors: Muchin, Michael P., Muchin, Jerome D.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): GHALI, ISIS A D
• Application Number:
  US09/292,625
• Time in Patent Office: 663 Days
• Field of Search: 424/448, 424/449, 424/447, 424/457, 424/443
• US Class Current: 424/448
• CPC Class Codes: A61F 2013/0296 for making transdermal patches (chemical processes excluded)
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Abstract

A carrier patch for delivering agents locally to the skin or systemically via the skin. The patch comprises a pad having a lower surface area to which an adhesive is adhered, and a primary agent applied to discrete regions of the patch in a manner to minimize the deleterious effects of the adhesive on the primary agent. The invention further comprises a method for the discrete application of the agent to the patch, and a method of using the patch for the delivery of the agent to the skin.

Claims

1. A carrier patch for the delivery of agents to the skin of a user, the patch comprising:

a pad having a surface area for adhering to the skin, the pad having a lower surface area,

an adhesive adhered to the lower surface area of the pad, the adhesive having a lower surface area; and

a primary agent for delivery to the skin, the primary agent having been applied on the adhesive lower surface area at discrete locations, and the agent being retained on the lower surface area of the adhesive, and the adhesive not requiring a subsequent treatment which treatment is deleterious to the efficacy of the primary agent, the primary agent being in direct contact with the skin when the patch is worn by the user, thereby to effect delivery of the primary agent to the skin.

2. The carrier patch as claimed in claim 1, wherein the deleterious treatment is at least one of a chemical, thermal or mechanical action.

3. The carrier patch as claimed in claim 1 further comprising a first liner adhered to the adhesive, the first liner being removable.

4. The carrier patch as claimed in claim 3, wherein the first liner has at least one well formed therein, and wherein the well defines selectively an aperture through which the primary agent is applied to the adhesive, or a dimple to protect the primary agent prior to use.

5. The carrier patch as claimed in claim 1, wherein the adhesive requires premoisturization prior to application to the skin.

6. The carrier patch as claimed in claim 1, wherein the adhesive does not require premoisturization prior to application to the skin.

7. The carrier patch as claimed in claim 1, wherein the adhesive includes a polymeric adhesive composition.

8. The carrier patch as claimed in claim 1, wherein the adhesive includes a pressure sensitive adhesive.

9. The carrier patch of claim 8, wherein the pressure sensitive adhesive comprises an acrylate adhesive.

10. The carrier patch as claimed in claim 1 wherein the primary agent is therapeutic.

11. The carrier patch as claimed in claim 1, wherein the adhesive of the carrier patch is active in the physical removal of keratotic plugs from the skin, the keratotic plug including dead epidermal cells formed within skin pores.

12. The carrier patch as claimed in claim 1, wherein the primary agent is distributed at least across a portion of the surface area of the patch.

13. The carrier patch as claimed in claim 1, wherein the primary agent is distributed over entirety of the surface area of the patch.

14. The carrier patch as claimed in claim 1, where the pad is formed by at least one of a cotton cloth, rayon cloth, tetron cloth, nylon cloth or plastic film.

15. The carrier patch as claimed in claim 1, where the adhesive includes at least one of a solvent, pigment or oil.

16. The carrier patch as claimed in claim 1, wherein the pad or adhesive further includes a secondary agent.

17. The carrier patch as claimed in claim 1, wherein the patch includes a cover adhered to the upper surface area of the pad, and wherein the cover is on an opposite side of the adhesive.