Targeting of sebaceous follicles as a treatment of sebaceous gland disorders

• US 6,183,773 B1
• Filed: 01/04/1999
• Issued: 02/06/2001
• Est. Priority Date: 01/04/1999
• Status: Expired due to Term

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Anderson, Richard Rox
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): GHALI, ISIS A D
• Application Number:
  US09/225,026
• Time in Patent Office: 764 Days
• Field of Search: 606/3-19, 424/450, 424/401, 514/859
• US Class Current: 424/450
• CPC Class Codes: A61K 41/0028 Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61K 41/0057 Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders

Abstract

Laser treatments of sebaceous gland disorders with laser sensitive dyes are disclosed. A preferred laser treatment includes topical application of an energy activatable material to the skin followed by laser irradiation.

Claims

1. A method for treating a sebaceous gland disorder comprising the steps of

a) topically applying a chromophore containing group to a section of skin afflicted with a sebaceous gland disorder, wherein said chromophore containing group is activated by energy which penetrates outer layers of epidermis,

b) causing a sufficient amount of said chromophore containing group to infiltrate into spaces in said skin;

and

c) exposing said section of skin to energy sufficient to cause said chromophore containing group to become photochemically or photothermally activated, thereby treating said sebaceous gland disorder.

2. The method of claim 1, wherein said chromophore containing group is methylene blue.

3. The method of claim 1, wherein said chromophore containing group is a laser sensitive material.

4. The method of claim 3, wherein said laser sensitive material is methylene blue.

5. The method of claim 1, wherein said chromophore containing group is suspended in a pharmaceutical carrier.

6. The method of claim 5, wherein said pharmaceutical carrier is a liposome.

7. The method of claim 6, wherein said pharmaceutical carrier is an oil.

8. The method of claim 7, wherein said oil is baby oil.

9. The method of claim 1, wherein said chromophore containing group penetrates said skin via a pilosebaceous unit.

10. The method of claim 1, wherein said treatment modifies the opening to the infundibulum.

11. The method of claim 10, wherein said opening is opened.

12. The method of claim 1, wherein said chromophore containing group penetrates a sebaceous gland.

13. The method of claim 12, wherein said sebaceous gland is modified.

14. The method of claim 1, wherein said sebaceous gland disorder is acne vulgaris, acne rosacea, or sebaceous gland hyperplasia.

15. The method of claim 1, wherein ultrasound is utilized to force said chromophore containing group into said spaces.

16. The method of claim 1, wherein said energy is from a pulsed laser dye.

17. The method of claim 1, wherein said energy is from a diode laser array.

18. The method of claim 1, wherein said spaces in said skin comprise spaces in hair ducts in said skin not occupied by hair.

19. The method of claim 1, wherein said spaces in said skin comprises space within sebaceous glands.

20. The method of claim 1, wherein said spaces in said skin comprise space adjacent to sebaceous glands.

21. A method for modifying the opening to the infundibulum comprising the steps of:

a) topically applying a chromophore containing group to the opening to the infundibulum, wherein said chromophore containing group is activated by energy which penetrates outer layers of epidermis,

b) causing a sufficient amount of said chromophore containing group to infiltrate into spaces about said infundibulum; and

c) exposing said section of skin with sufficient energy to cause said chromophore containing group to become photochemically or photothermally activated, thereby modifying said opening to the infundibulum.

23. The method of claim 21, wherein said chromophore containing group is a laser sensitive material.

24. The method of claim 23, wherein said laser sensitive material is methylene blue.

22. A method for modifying the pilosebaceous unit comprising the steps of:

a) topically applying a chromophore containing group to the pilosebaceous unit, wherein said chromophore containing group is activated by energy which penetrates outer layers of epidermis,

b) causing a sufficient amount of said chromophore containing group to infiltrate the pilosebaceous unit; and

c) exposing said section of skin with sufficient energy to cause said chromophore containing group to become photochemically or photothermally activated, thereby modifying the pilosebaceous unit.

25. The method of claim 22, wherein said chromophore containing group is a laser sensitive material.

26. The method of claim 25, wherein said laser sensitive material is methylene blue.