MR tomograph comprising a positioning system for the exact determination of the position of a manually guided manipulator

• US 6,185,445 B1
• Filed: 07/22/1998
• Issued: 02/06/2001
• Est. Priority Date: 07/30/1997
• Status: Expired due to Term

• Current Assignee: Bruker Biospin GMBH (Bruker Corporation)
• Original Assignee: Bruker Medizintechnik GmbH
• Inventors: Knüttel, Bertold
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): PATEL, MAULIN M
• Application Number:
  US09/120,321
• Time in Patent Office: 930 Days
• Field of Search: 600/439, 600/124, 601/2, 602/3, 603/4, 606/130
• US Class Current: 600/411
• CPC Class Codes: A61B 10/0233 Pointed or sharp biopsy instruments
• CPC Class Codes: A61B 90/11 with guides for needles or instruments, e.g. arcuate slides or ball joints
• CPC Class Codes: A61B 90/36 Image-producing devices or illumination devices not otherwise provided for
• CPC Class Codes: G01R 33/285 Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR

Abstract

An MR tomograph, the magnet system (2) and gradient system of which permit access to the investigation volume along at least two essentially orthogonal axes, comprises a positioning system for the exact determination of the position of a manually guided manipulator (12) relative to the measuring object (6) which is investigated by means of imaging MR measurement and located in the investigation volume (3) of the MR tomograph (1); with a mounting frame (11) with which the manipulator (12) is connected via movable mechanics comprising a measuring means through which the respective spatial position of the manipulator (12) relative to the mounting frame (11) can be determined, wherein the measuring means of the movable mechanics does not utilize any MR signals and wherein the measured position of the manipulator (12) is displayed on the MR image. In this way, minimum-invasive operations, e.g. by means of a biopsy needle, can be carried out manually and the position of the manipulator, used in this connection, within the measuring object can be monitored by means of simultaneously recorded MR slice images during the operation and can be corrected, if necessary.

Claims

1. A positioning system for the exact determination of the position of a biopsy needle, relative to a measuring object, in particular the head, mamma or extremities of a patient, investigated by means of a magnetic resonance (MR) imaging measurement and located in an investigation volume of an MR tomograph, the MR tomograph having a magnet system for the generation of a homogenous magnetic field within the investigation volume and a gradient system for generating magnetic field gradient fields which vary linearly in the investigation volume, wherein the magnet system and the gradient system permit access to the investigation volume along at least two axes which intersect at an essentially right angle, the MR tomograph having a radio-frequency (RF) transmitting and receiving system for radiating RF pulses onto the measuring object and for receiving MR signals from the measuring object as well as an evaluation and display means for generating and displaying an MR image from inside the measuring object, the positioning system comprising:

a first frame component disposed on and without relative motion with respect to the measuring object;

a marking member disposed on said first frame component within the investigation volume in which the magnetic field is homogenous and the gradient fields are linear, said marking member comprising an MR substance in which measureable MR signals can be excited to define a position of said first frame component in the MR image via an imaging MR measurement;

a second frame component to which the biopsy needle is mounted, said second frame component movable relative to said first frame component;

movable mechanics disposed on said second frame component for moving the biopsy needle relative to said first frame component;

measuring means for determining a spatial position of the biopsy needle relative to said first frame component without using any MR signal; and

means for displaying said spatial position in the MR image.

2. The positioning system of claim 1, further comprising evaluation means for determining a position of the biopsy needle in the MR image by calculation on the basis of said position of said first frame component determined by means of imaging MR measurement and said position of the biopsy needle relative to said first frame component determined by said measuring means without MR measurement.

3. The positioning system of claim 1, wherein said MR substance comprises protons.

4. The positioning system of claim 1, wherein said MR substance is a gel.

5. The positioning system of claim 2, wherein said measuring means effect a path length measurement using at least one of a mechanical member, an electrical member, a piezoelectrical member and an optical member.

6. The positioning system of claim 1, wherein said MR substance is rigidly connected to the measuring object.

7. The positioning system of claim 1, wherein said MR substance is rigidly connected to said first frame component.

8. The positioning system of claim 1, wherein the entire positioning system consists essentially of non-magnetic materials.

9. The positioning system of claim 1, wherein said movable mechanics comprises an angle member for mechanically guiding the biopsy needle within a range of solid angle and wherein said measuring means comprise means for determining an angular position of the biopsy needle.

10. The positioning system of claim 9, wherein said angle member comprises a ball joint.

11. The positioning system of claim 10, wherein the manipulator comprises a biopsy needle.

12. The positioning system of claim 9 wherein said movable mechanics effects two-dimensional motion in the manner of a gimbal mounting.

13. The positioning system of claim 1, wherein said movable mechanics displace the biopsy needle relative to said first frame component along two substantially circular and substantially mutually perpendicular arcs.

14. The positioning system of claim 1, wherein said movable mechanics comprise guiding means for moving the biopsy needle relative to said second frame component and said measuring means comprise means for determining an axial position of the biopsy needle relative to said guiding means.

15. A method for determining the exact position of a tip of a biopsy needle relative to a measuring object, in particular the head, mamma or extremities of a patient, investigated by means of a magnetic resonance (MR) imaging measurement and located in an investigation volume of a MR tomograph, the MR tomograph having a magnet system for the generation of a homogenous magnetic field within the investigation volume and a gradient system for generating magnetic gradient fields which vary linearly in the investigation volume, wherein the magnet system and the gradient system permit access to the investigation volume along at least two axes which intersect at an essentially right angle, the MR tomograph having a radio-frequency (RF) transmitting and receiving system for irradiating RF pulses onto the measuring object and for receiving MR signals from the measuring object as well as an evaluation and display means for generating and displaying an MR image from inside the measuring object, the method comprising the steps of:

a) disposing a first frame component on and without relative motion with respect to the measuring object, said first frame component having a marking member disposed on said first frame component within the investigation volume in which the magnetic field is homogenous and the gradient fields are linear, said marking member comprising an MR substance in which measurable MR signals can be excited;

b) moving the biopsy needle relative to said first frame component using a second frame component to which the biopsy needle is mounted, said second frame component being movable relative to said first frame component;

c) determining a spatial position of the biopsy needle relative to said first frame component without using any MR signal;

d) determining an absolute position of said first frame component using imaging MR measurements simultaneously during actuation of the biopsy needle and using measuring signals from said marking member; and

e) displaying said spatial position of the biopsy needle in the image.

16. The method of claim 15, wherein a relative position of the biopsy needle with respect to said first frame component is determined repeatedly and simultaneously during actuation of the biopsy needle using at least one of mechanical, electrical, piezoelectrical and optical measuring signals.

17. The method of claim 15, wherein an absolute position of a certain section of said biopsy needle located within the measuring object is determined during manipulation by computer calculation and is faded into the MR image.

18. A method for guiding a tip of a biopsy needle to a predetermined point inside a measuring object, wherein the biopsy needle is guided on two circular arcs outside of the measuring object in a defined manner and can be displaced along an axis located essentially perpendicular to the circular arcs, the method comprising the steps of:

a) disposing a first frame component on and without relative motion with respect to the measuring object, said first frame component having a marking member disposed on said first frame component within the investigation volume in which the magnetic field is homogenous and the gradient fields are linear, said marking member comprising an MR substance in which measurable MR signals can be excited;

b) locating the biopsy needle outside of the measuring object;

c) displaying an MR image of the measuring object;

d) marking a desired position on said MR image;

e) determining, using evaluation and display means, optimum coordinates along the circular arcs and the axis;

f) fading permanently updated deviations from said optimum coordinates into the MR image;

g) manually minimizing said deviations through movement of said biopsy needle along the circular arc; and

h) manually inserting said biopsy needle into the measuring object along the axis taking into consideration said permanently updated deviation until a tip of the biopsy needle is located at said desired position.

19. The method according to claim 18, further comprising assisting the graphic display with an acoustic display.

20. A positioning system for the exact determination of the position of a manually guided manipulator, in particular a tip of a biopsy needle, relative to a measuring object, in particular the head, mamma or extremities of a patient, investigated by means of a magnetic resonance (MR) imaging measurement and located in an investigation volume of an MR tomograph, the MR tomograph having a magnet system for the generation of a homogenous magnet field within the investigation volume and a gradient system for generating magnetic gradient fields which vary linearly in the investigation volume, wherein the magnet system and the gradient system permit access to the investigation volume along at least two axes which intersect at an essentially right angle, the MR tomograph having a radio frequency (RF) transmitting and receiving system for irradiating RF pulses onto the measuring object and for receiving MR signals from the measuring object as well as an evaluation and display means for generating and displaying an MR image from inside the measuring object, the positioning system comprising:

a first frame component disposed on and without relative motion with respect to the measuring object;

a marking member disposed on said first frame component within the investigation volume in which the magnetic field is homogenous and the gradient fields are linear, said marking member comprising an MR substance in which measureable MR signals can be excited to define a position of said first frame component in the MR image via an imaging MR measurement;

a second frame component to which the manipulator is mounted, said second frame component movable relative to said first frame component;

movable mechanics disposed on said second frame component for moving the manipulator relative to said first frame component;

measuring means for determining a spatial position of the manipulator relative to said first frame component without using any MR signal;

means for displaying said spatial position in the MR image, wherein said movable mechanics comprises an angle member for mechanically guiding the manipulator within a range of solid angle and wherein said measuring means comprise means for determining an angular position of the manipulator, wherein said angle member comprises a ball joint.

21. A positioning system for the exact determination of the position of a manually guided manipulator, in particular a tip of a biopsy needle, relative to a measuring object, in particular the head, mamma or extremities of a patient, investigated by means of a magnetic resonance (MR) imaging measurement and located in an investigation volume of a MR tomograph, the MR tomograph having a magnet system for the generation of a homogenous magnetic field within the investigation volume and a gradient system for generating magnetic gradient fields which vary linearly in the investigation volume, wherein the magnet system and the gradient system permit access to the investigation volume along at least two axes which intersect at an essentially right angle, the MR tomograph having a radio-frequency (RF) transmitting and receiving system for radiating RF pulses onto the measuring object and for receiving MR signals measuring means for determining a spatial position of the manipulator relative to said first frame component without using any MR signal;

means for displaying said spatial position in the MR image, wherein said movable mechanics comprises an angle member for mechanically guiding the manipulator within a range of solid angle and wherein said measuring means comprise means for determining an angular position of the manipulator, wherein said angle member comprises a ball joint.