Unit dose dispensing device

• US 6,186,141 B1
• Filed: 01/29/1999
• Issued: 02/13/2001
• Est. Priority Date: 05/10/1996
• Status: Expired due to Term

• Current Assignee: Glaxo Wellcome Australia Limited (GSK plc), Glaxo Wellcome Incorporated (GSK plc)
• Original Assignee: Glaxo Wellcome Incorporated (GSK plc)
• Inventors: Pike, Gregory Charles, Riedel, Ingo Helmuth, Smith, Stephan
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): MITCHELL, TEENA KAY
• Application Number:
  US09/180,277
• Time in Patent Office: 746 Days
• Field of Search: 128/200.14, 128/200.18, 128/200.22, 128/200.23, 128/203.12, 128/203.21, 128/205.21, 239/3, 239/690, 239/692, 239/704, 239/706, 239/33, 239/338
• US Class Current: 128/203.12
• CPC Class Codes: A61B 18/12 by passing a current through the tissue to be heated, e.g. high-frequency current
• CPC Class Codes: A61B 18/1206 Generators therefor
• CPC Class Codes: A61B 18/14 Probes or electrodes therefor
• CPC Class Codes: A61B 2018/0066 without feedback, i.e. open loop control
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0036 hollow piercing means
• CPC Class Codes: A61M 15/0041 with movable piercing or cutting means
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/073 Syringe, piston type
• CPC Class Codes: A61N 5/04 Radiators for near-field treatment

Abstract

A device for dispensing a unit dose of substance comprises a nozzle assembly (2) including a container (24) housing a unit dose of the substance, and an outer body (4) to which the nozzle assembly (2) is releasably attached. The body (4) includes a system actuable to effect discharge of the substance from the nozzle assembly (2) and actuating means operably by a user to effect discharge. Preferably the discharge system comprises a spring-loaded air piston (68) actuable to inject air into the container (24) to cause discharge of the substance. In one embodiment a driving spring for the air piston is loaded with spring energy by the action of installing the nozzle assembly on the body, the driving spring thereafter being held in a cocked state until operating of the actuating means by the user to effect release of the spring energy to cause discharge.

Claims

1. A nozzle assembly for intranasal administration of a unit dose of a substance, said nozzle assembly being adapted for releasable attachment to a body having a system actuable to effect discharge of a substance, said nozzle assembly comprising a container which houses a unit dose of a substance, means for releasably attaching the nozzle assembly to the body, and dispensing means co-operable with said discharge system whereby the discharge system of the body comprises a ram, and the dispensing means of the nozzle assembly comprises means for piercing the container in response to the movement of the ram, such that dispensing of a substance from the container occurs in response to movement of the ram.

2. A nozzle assembly according to claim 1, wherein the nozzle assembly includes a passage which receives the ram either when the nozzle assembly is being mounted on the body or subsequently thereto.

3. A nozzle assembly according to claim 1, wherein the container is in the form of a capsule mounted within a chamber in the nozzle assembly, and the piercing means comprises a hollow needle mounted at an outer end of the chamber whereby the capsule is displaceable by the action of the ram towards the outer end of the chamber to cause piercing by the needle.

4. A nozzle assembly according to claim 1, wherein the discharge system of the body comprises means for injecting gas into the container, and wherein the container within the nozzle assembly is in the form of a capsule mounted within a chamber in the nozzle assembly, and the piercing means comprises a first hollow needle mounted at an outer end of the chamber and a second hollow needle carried by a piston within an inner end portion of the chamber, with the capsule lying within the chamber between the first and second needles, the arrangement being such that the piston is displaceable within the chamber under the action of the ram to displace the second needle towards the first needle to cause the two needles to pierce opposite ends of the capsule, whereby dispensing gas from the discharge system of the body can be injected into the capsule via the second needle such that a substance is dispensed from the capsule via the first needle under the effect of the injected gas.

5. A nozzle assembly according to claim 4, wherein the first needle leads into a swirl chamber upstream of an outlet orifice of the nozzle assembly.

6. A body for use with a nozzle assembly according to claim 4, said body comprising a system to effect discharge of a substance from the nozzle assembly, means co-operable with the attachment means of the nozzle assembly to releasably retain the nozzle assembly relative to the body, and actuating means operable by a user to effect discharge, wherein the discharge system comprises a ram which is co-operable with the nozzle assembly to effect piercing of the capsule by the first and second needles, said discharge system further comprising means for injecting air into the capsule via the second needle whereby to cause discharge of a substance via the first needle.

7. A body according to claim 6, wherein the ram includes an air passage which communicates with the second needle for injection of air into the capsule.

8. A body according to claim 7, wherein the means for injecting air comprises an air piston which is spring-loaded to inject air into the capsule via the air passage in the ram upon operation of the actuating means by the user.

9. A body according to claim 8, wherein the actuating means is operative initially to load a driving spring of the air piston with spring energy and to thereafter release said spring energy whereby the air piston is driven to inject air.

10. A body according to claim 8, wherein the means for releasably retaining the nozzle assembly comprises support means for the nozzle assembly, said support means being displaceable by the nozzle assembly when mounting the nozzle assembly to the body, said movement of the support means serving to load a driving spring of the air piston with spring energy, and means for retaining the driving spring in its loaded state, said retaining means being releasable in response to operation of the actuating means by the user whereby the air piston is then driven by the driving spring to effect discharge of a substance.

11. A body according to claim 10, for use with a nozzle assembly according to claim 6, wherein the support means is adapted to cooperate with the inner end of the protecting tubular portion of the nozzle when the tubular portion is inserted into the body, and the support means is displaceable within the body as a result of insertion movement of the tubular portion of the nozzle assembly in the direction of the axis of the tubular portion.

12. A body according to claim 11, wherein the means for releasably retaining the nozzle assembly further comprises means for releasably locking the tubular portion of the nozzle assembly to the support means to prevent release of the nozzle assembly during discharge.

13. A body according to claim 8, wherein the actuating means is linked to the ram such that initial operation of the actuating means displaces the ram to cause piercing of the capsule prior to release of spring energy of a driving spring of the air piston.

14. A body according to claim 8, wherein the ram is subject to the action of a driving spring of the air piston such that release of a spring energy upon operation of the actuating means will also effect driving movement of the ram to effect piercing of the capsule.

15. A nozzle assembly according to claim 1, wherein the means for releasably attaching the nozzle assembly to the body comprises a projecting tubular portion of the nozzle assembly insertable into an opening in the body, the tubular portion including a locking formation releasably engagable with locking means of the body.

16. A nozzle assembly according to claim 15 when dependent on claim 2, wherein the tubular portion includes the passage which receives the ram of the discharge system.

17. A nozzle assembly according to claim 1, wherein the outer end portion of the nozzle assembly is of a size such that it can be inserted into a nasal cavity.

18. A body for use with a nozzle assembly according to claim 1, said body comprising a system to effect discharge of a substance from the nozzle assembly, means co-operable with the attachment means of the nozzle assembly to releasably retain the nozzle assembly relative to the body, a and actuating means operable by a user to effect discharge wherein the discharge system comprises a ram which is co-operable-with the nozzle assembly.

19. A body according to claim 18, wherein the body is of a configuration such that it can be held in a hand of a user and the actuating means comprises at least one actuating member which can be actuated by a digit of the same hand.

21. A device for dispensing a unit dose of a substance comprising a nozzle assembly for intranasal administration of a unit dose of a substance, said nozzle assembly being adapted for releasable attachment to a body having a system actuable to effect discharge of a substance, said nozzle assembly comprising a container which houses a unit dose of a substance, means for releasably attaching the nozzle assembly to the body, and dispensing means co-operable with said discharge system whereby the discharge system of the body comprises a ram, and the dispensing means of the nozzle assembly comprises means for piercing the container in response to the movement of the ram, such that dispensing of a substance from the container occurs in response to movement of the ram, and a body according to claim 18, the nozzle assembly being attachable to the body for cooperation with the discharge system of the body.

20. A nozzle assembly for dispensing a unit dose of a substance, said nozzle assembly being adapted for releasable attachment to a body having a system actuable to effect discharge of a substance by the injection of air, said nozzle assembly comprising a capsule housing a unit dose of a substance, said capsule being mounted between outer and inner hallow needles at opposite ends of the capsule, the inner needle being displaceable towards the outer needle under the action of a ram so as to pierce the capsule whereby dispensing of a substance can then be effected by injecting air from the discharge system of the body into the capsule via the inner needle with a substance being discharged from the capsule via the outer needle.

22. A device for dispensing a unit dose of a substance, said device comprising a nozzle assembly including a container housing a unit dose of a substance, and a body to which the nozzle assembly is releasably attached, said body including a system actuably to effect discharge of a substance from the nozzle assembly, and actuating means operable by a user to effect discharge, the nozzle assembly being removable from the body after use and being replaceable by a further such nozzle assembly to permit dispensing of a unit dose of a substance from that nozzle assembly, wherein the discharge system comprises a spring-loaded air piston actuable to inject air into the container to cause discharge of a substance.

23. A device according to claim 22, wherein a driving spring for the air piston is loaded with spring energy by the action of installing the nozzle assembly on the body, said driving spring thereafter being held in a cocked state until operation of the actuating means by the user to effect release of the spring energy to cause discharge.