Method and apparatus for three-dimensional flow imaging using coded excitation

• US 6,186,949 B1
• Filed: 10/04/1999
• Issued: 02/13/2001
• Est. Priority Date: 03/31/1998
• Status: Expired due to Fees

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Chiao, Richard Yung, Hatfield, William Thomas
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): Imam, Ali M.
• Application Number:
  US09/411,207
• Time in Patent Office: 498 Days
• Field of Search: 600/437, 600/441, 600/443, 600/447, 600/458, 128/916, 736/02, 367/138
• US Class Current: 600/443
• CPC Class Codes: G01S 15/8959 using coded signals for correlation purposes
• CPC Class Codes: G01S 15/8981 Discriminating between fixed and moving objects or between objects moving at different speeds, e.g. wall clutter filter
• CPC Class Codes: G01S 15/8988 Colour Doppler imaging
• CPC Class Codes: G01S 15/8993 Three dimensional imaging systems
• CPC Class Codes: G01S 7/52038 involving non-linear properties of the propagation medium or of the reflective target
• CPC Class Codes: G01S 7/52039 exploiting the non-linear response of a contrast enhancer, e.g. a contrast agent diagnostic techniques involving the use of contrast agents A61B8/481
• CPC Class Codes: G01S 7/52046 Techniques for image enhancement involving transmitter or receiver image enhancement by image data processing G06T5/00
• CPC Class Codes: G01S 7/5206 Two-dimensional coordinated display of distance and direction; B-scan display
• CPC Class Codes: Y10S 128/916 Ultrasound 3-D imaging

Abstract

In performing three-dimensional flow imaging using coded excitation and wall filtering, a coded sequence of broadband pulses (centered at a fundamental frequency) is transmitted multiple times to a particular transmit focal position. On receive, the receive signals acquired for each firing are compressed and bandpass filtered to isolate a compressed pulse centered at the fundamental frequency. The compressed and isolated signals are then wall filtered to extract the flow imaging data. This process is repeated for a multiplicity of transmit focal positions in each of a multiplicity of scanning planes to acquire a volume of flow imaging data. Volume rendered images are then produced which allow the user to view the data volume from any angle. In addition, the data volume may be reformatted to produce two-dimensional images of arbitrary cut planes through the data volume.

Claims

1. An imaging system comprising:

a transducer array having a multiplicity of transducer elements for transmitting wave energy centered at a fundamental frequency in response to electrical activation and for transducing returned wave energy into electrical signals;

a transmitter coupled to said transducer array and programmed to activate a plurality of said transducer elements to transmit focused wave energy encoded with a transmit code during first and second transmit events for each of a multiplicity of transmit focal positions in each of a multiplicity of scan planes;

a receiver programmed to respectively form first and second receive signals from electrical signals produced by said plurality of transducer elements subsequent to said first and second transmit events respectively for each of a multiplicity of scan lines in each of said scan planes;

a wall filter programmed with first and second sets of filter coefficients to compress and bandpass first and second fundamental signal components of said first and second receive signals respectively and selectively pass frequencies corresponding to wave energy reflectors moving at a velocity above a predetermined threshold, said wall filter forming a respective flow signal derived at least in part from the compressed and bandpassed first and second fundamental signal components and the selectively passed frequencies for each of said scan lines in each of said scan planes;

a memory for storing a respective set of flow signals for each of said scan planes to form a data volume;

a computer programmed to generate imaging data representing a three-dimensional projection of said data volume having a controllable orientation onto an imaging plane by applying a projection transformation to said data volume; and

a subsystem for displaying an image which is a function of said three-dimensional projection.

2. The system as recited in claim 1, wherein said second set of filter coefficients are the negative of said first set of filter coefficients.

3. The system as recited in claim 1, wherein all but at least one of said second set of filter coefficients are the negative of said first set of filter coefficients, said at least one of said filter coefficients being perturbed to allow B-mode fundamental signal feedthrough.

4. The system as recited in claim 1, wherein said transmitter is further programmed to activate a plurality of said transducer elements to transmit focused wave energy which is uncoded during a third transmit event for each transmit focal position, said receiver is further programmed to form a third receive signal from electrical signals produced by said plurality of transducer elements subsequent to said third transmit event for each of said scan lines, and said wall filter is further programmed with a third set of filter coefficients to bandpass a harmonic signal component of said third receive signal for summing with said compressed and bandpassed first and second fundamental signal components and the selectively passed frequencies for each of the scan lines in each of said scan planes.

5. The system as recited in claim 1, wherein said transmitter is further programmed to activate a plurality of said transducer elements to transmit focused wave energy which is uncoded during third and fourth transmit events for each transmit focal position, said uncoded focused wave energy of said third transmit event being of opposite polarity to said uncoded focused wave energy of said fourth transmit event, said receiver is further programmed to form third and fourth receive signals from electrical signals produced by said plurality of transducer elements subsequent to said third and fourth transmit events respectively for each of said scan lines, and said wall filter is further programmed with third and fourth sets of filter coefficients to bandpass respective harmonic signal components of said third and fourth receive signals for summing with said compressed and bandpassed first and second fundamental signal components and the selectively passed frequencies for each of the scan lines in each of said scan planes while substantially canceling respective fundamental signal components of said third and fourth receive signals.

6. The system as recited in claim 1, wherein said transducer elements comprise piezoelectric elements for transmitting ultrasound waves in response to electrical activation and for transducing returned ultrasound waves into electrical signals.

7. An imaging system comprising:

a transducer array having a multiplicity of transducer elements for transmitting wave energy centered at a fundamental frequency in response to electrical activation and for transducing returned wave energy into electrical signals;

a transmitter coupled to said transducer array and programmed to activate a plurality of said transducer elements to transmit focused wave energy encoded with a first Golay code of a Golay code pair during first and third transmit events and transmit focused wave energy encoded with a second Golay code of said Golay code pair during second and fourth transmit events for each of a multiplicity of transmit focal positions in each of a multiplicity of scan planes;

a receiver programmed to respectively form first through fourth receive signals from electrical signals produced by said plurality of transducer elements subsequent to said first through fourth transmit events respectively for each of a multiplicity of scan lines in each of said scan planes;

a wall filter programmed with first through fourth sets of filter coefficients to decode and bandpass first through fourth fundamental signal components of said first through fourth receive signals respectively and selectively pass frequencies corresponding to wave energy reflectors moving at a velocity above a predetermined threshold, said wall filter forming a flow signal derived at least in part from said decoded and bandpassed first through fourth fundamental signal components and the selectively passed frequencies for each of said scan lines in each of said scan planes;

a memory for storing a respective set of flow signals for each of said scan planes to form a data volume;

a computer programmed to generate imaging data representing a three-dimensional projection of said data volume having a controllable orientation onto an imaging plane by applying a projection transformation to said data volume; and

a subsystem for displaying an image which is a function of said three-dimensional projection.

8. The system as recited in claim 7, wherein said third set of filter coefficients are the negative of said first set of filter coefficients, and said fourth set of filter coefficients are the negative of said second set of filter coefficients.

9. The system as recited in claim 7, wherein said third set of filter coefficients are the negative of said first set of filter coefficients, and said fourth set of filter coefficients are the negative of said second set of filter coefficients, with at least one pair of said filter coefficients being perturbed to allow B-mode fundamental signal feedthrough.

10. The system as recited in claim 7, wherein said transmitter is further programmed to activate a plurality of said transducer elements to transmit focused wave energy which is uncoded during a fifth transmit event for each of said transmit focal positions, said receiver is further programmed to form a fifth receive signal from electrical signals produced by said plurality of transducer elements subsequent to said fifth transmit event for each of said scan lines, and said wall filter is further programmed with a fifth set of filter coefficients to bandpass a harmonic signal component of said fifth receive signal for summing with said compressed and bandpassed first through fourth fundamental signal components and the selectively passed frequencies for each of said scan lines in each of said scan planes.

11. The system as recited in claim 7, wherein said transmitter is further programmed to activate a plurality of said transducer elements to transmit focused wave energy which is uncoded during fifth and sixth transmit events for each of said transmit focal positions, said uncoded focused wave energy of said fifth transmit event being of opposite polarity to said uncoded focused wave energy of said sixth transmit event, said receiver is further programmed to form fifth and sixth receive signals from electrical signals produced by said plurality of transducer elements subsequent to said fifth and sixth transmit events respectively for each of said scan lines, and said wall filter is further programmed with fifth and sixth sets of filter coefficients to bandpass respective harmonic signal components of said fifth and sixth receive signals for summing with said compressed and bandpassed first through fourth fundamental signal components and the selectively passed frequencies for each of said scan lines in each of said scan planes while substantially canceling respective fundamental signal components of said fifth and sixth receive signals.

12. The system as recited in claim 7, wherein said transducer elements comprise piezoelectric elements for transmitting ultrasound waves in response to electrical activation and for transducing returned ultrasound waves into electrical signals.

13. An imaging system comprising:

a transducer array having a multiplicity of transducer elements for transmitting wave energy centered at a fundamental frequency in response to electrical activation and for transducing returned wave energy into electrical signals;

a display monitor for displaying an image; and

a computer programmed to perform the steps of;

(a) activating transducer elements of said array to transmit focused wave energy encoded with a transmit code during first and second transmit events for each of a multiplicity of transmit focal positions in each of a multiplicity of scan planes;

(b) forming first and second receive signals from electrical signals produced by said transducer elements subsequent to said first and second transmit events respectively for each of a multiplicity of scan lines in each of said scan planes;

(c) compressing, bandpassing and wall filtering first and second fundamental signal components of said first and second receive signals respectively to form a flow signal for each of said scan lines in each of said scan planes;

(d) storing a respective set of flow signals for each of said scan planes to form a data volume;

(e) generating imaging data representing a three-dimensional projection of said data volume having a controllable orientation onto an imaging plane by applying a projection transformation to said data volume; and

(f) sending said imaging data representing a three-dimensional projection to said display monitor.

14. The system as recited in claim 13, wherein said computer includes an FIR filter and a vector summer coupled to said FIR filter for performing step (c).

15. The system as recited in claim 13, wherein said transducer elements comprise piezoelectric elements for transmitting ultrasound waves in response to electrical activation and for transducing returned ultrasound waves into electrical signals.

16. An imaging system comprising:

a transducer array having a multiplicity of transducer elements for transmitting wave energy centered at a fundamental frequency in response to electrical activation and for transducing returned wave energy into electrical signals;

a display monitor for displaying an image; and

a computer programmed to perform the steps of;

(a) activating transducer elements of said array to transmit focused wave energy encoded with a first Golay code of a Golay code pair during first and third transmit events and to transmit focused wave energy encoded with a second Golay code of said Golay code pair during second and fourth transmit events for each of a multiplicity of transmit focal positions in each of a multiplicity of scan planes;

(b) forming first through fourth receive signals from electrical signals produced by said transducer elements subsequent to said first through fourth transmit events respectively for each of a multiplicity of scan lines in each of said scan planes;

(c) decoding, bandpassing and wall filtering first through fourth fundamental signal components of said first through fourth receive signals respectively to form a flow signal for each of said scan lines in each of said scan planes;

(d) storing a respective set of flow signals for each of said scan planes to form a data volume;

(e) generating imaging data representing a three-dimensional projection of said data volume having a controllable orientation onto an imaging plane by applying a projection transformation to said data volume; and

(f) applying said imaging data representing a three-dimensional projection to said display monitor.

17. The system as recited in claim 16, wherein said computer includes an FIR filter and a vector summer coupled to said FIR filter for performing said step (c).

18. The system as recited in claim 16, wherein said transducer elements comprise piezoelectric elements for transmitting ultrasound waves in response to electrical activation and for transducing returned ultrasound waves into electrical signals.

19. A method for imaging flow of blood in a body, comprising the steps of:

transmitting N encoded focused beams of wave energy having a fundamental frequency for each of a multiplicity of transmit focal positions in each of a multiplicity of scan planes intersecting the body, where N≧

2;

generating echo signals derived from echoes of wave energy returned from the body following each transmission of a focused beam for each of a multiplicity of scan lines in each of said scan planes;

filtering a fundamental signal component for each of said echo signals to form a flow signal indicative of blood flow for each of said scan lines in each of said scan planes;

storing a respective set of flow signals for each of said scan planes to form a data volume;

generating imaging data representing a three-dimensional projection of said data volume having a controllable orientation onto an imaging plane; and

displaying an image as a function of said three-dimensional projection.

20. The method as recited in claim 19, further comprising the step of injecting a contrast agent into the body prior to the step of transmitting.

21. The method as recited in claim 19, wherein the step of filtering comprises compressing, band-passing and wall filtering said fundamental signal component.

22. A system for imaging flow of blood in a body, comprising:

a transducer array having a multiplicity of transducing elements;

a transmitter for activating said transducer array to transmit N encoded focused beams of wave energy having a fundamental frequency for each of a multiplicity of transmit focal positions in each of a multiplicity of scan planes intersecting the body, where N≧

2;

a receiver for receiving echo signals derived from echoes of wave energy returned from the body to said transducer array following each transmission of a focused beam for each of a multiplicity of scan lines in each of said scan planes;

a filter for filtering a fundamental signal component for each of said echo signals to form a flow signal indicative of blood flow for each of said scan lines in each of said scan planes;

a memory for storing a respective set of flow signals for each of said scan planes to form a data volume;

a computer programmed to generate first imaging data representing a three-dimensional projection of said data volume having a controllable orientation onto an imaging plane in a first imaging mode; and

a display subsystem for displaying an image as a function of said three-dimensional projection.

23. The system as recited in claim 22, wherein said computer includes an FIR filter, a vector summer coupled to said FIR filter, and a filter coefficient memory for providing filter coefficients to said FIR filter, said filter coefficients being selected to compress and bandpass said fundamental signal component and, in combination with said vector summer, to wall filter the compressed and bandpassed fundamental signal component.

24. The system as recited in claim 22, wherein said computer is further programmed to generate second imaging data representing a slice through said data volume in a second imaging mode.

25. The system as recited in claim 22, further comprising an operator interface for selecting said orientation of said data volume.

26. A method of operating an imaging system including a multiplicity of transducer elements for transmitting wave energy in response to electrical activation and for transducing returned wave energy into electrical signals, and a display monitor for displaying an image, said method comprising the steps of:

(a) activating transducer elements of said array to transmit encoded focused wave energy during first through N-th transmit events for each of a multiplicity of transmit focal positions in each of a multiplicity of scan planes;

(b) forming first through N-th receive signals from electrical signals produced by said plurality of transducer elements subsequent to said first through N-th transmit events, respectively, for each of a multiplicity of scan lines in each of said scan planes;

(c) compressing, bandpassing and wall filtering first through N-th fundamental signal components of said first through N-th receive signals, respectively, to form a respective flow signal for each of said scan lines in each of said scan planes;

(d) storing a respective set of flow signals for each of said scan planes to form a data volume;

(e) generating imaging data representing a three-dimensional projection of said data volume having a controllable orientation onto an imaging plane by applying a projection transformation to said data volume; and

(f) displaying an image as a function of said three-dimensional projection.

27. The method as recited in claim 26, wherein the wave energy is encoded with a predetermined transmit code for each of said first through N-th transmit events.

28. The method as recited in claim 26, wherein the wave energy is encoded with a first Golay code of a Golay code pair during one half of said first through N-th transmit events, and is encoded with a second Golay code of said Golay code pair during the other half of said first through N-th transmit events.

29. An ultrasound diagnostic system for displaying three-dimensional images of stationary and moving reflectors for an area of interest in a patient, comprising:

a transmitter for transmitting multiple sequences of at least two B-mode pulses to a volume of interest, wherein said at least two B-mode pulses in at least one sequence are transmitted to a common transmit focal position;

a receiver for receiving B-mode echo signals containing a fundamental frequency component and being associated with said B-mode pulses, said B-mode echo signals defining a three-dimensional data volume containing B-mode and B-mode flow information;

a filter for receiving said B-mode echo signals and, based thereon, producing a filtered output signal containing flow image information for moving reflectors in said three-dimensional data volume, said filtered signal containing B-mode information for stationary reflectors in said three-dimentional data volume, said B-mode information for stationary reflectors including said fundamental frequency component; and

a display for displaying a three-dimensional image comprising a B-mode flow image component of moving reflectors and a B-mode image component of stationary reflectors based on said filtered output signal.

30. The system of claim 29, further comprising:

a three-dimensional B-mode flow processor for forming a projection representative of a three-dimensional B-flow image based on said filtered output signal.

31. The system of claim 30, wherein said display is adapted to display three-dimensional B-mode and three-dimensional B-mode flow information summed with one another as said B-flow image.

32. An ultrasound imaging system comprising:

a transmitter for transmitting focused wave energy encoded with a transmit code during first and second transmit events for each of a multiplicity of transmit focal positions in each of a multiplicity of scan planes;

a receiver for forming first and second receive signals from said first and second transmit events, respectively, for each of a multiplicity of scan lines in each of said scan planes;

a filter for forming a flow signal from said first and second receive signals for each of said scan lines in each of said scan planes, a first flow signal being based on a weighted sum of said first and second receive signals;

a computer for generating imaging data representing a three-dimensional projection of a data volume containing a set of flow signals for each scan plane; and

a display for displaying a three-dimensional image which is a function of said three-dimensional projection.

33. The system of claim 32, wherein said filter comprises a wall filter programmed with first and second sets of filter coefficients to compress and bandpass first and second signal components of said first and second receive signals, respectively.

34. The system of claim 32, wherein the filter is adapted to selectively pass frequencies corresponding to wave energy from moving reflectors.

35. The system of claim 32, wherein said filter is adapted to derive said flow signals from compressed and bandpassed first and second fundamental signal components of said first and second received signals, respectively.

36. The system of claim 32, wherein said filter is adapted to derive said flow signals from selectively passed frequencies of said first and second received signals.

37. The system of claim 32, further comprising:

a memory for storing a respective set of flow signals for each of said scan planes to form a data volume.

38. An ultrasound imaging system comprising:

a transmitter for transmitting broadband focused wave energy encoded with a first Golay code of a Golay code pair during first and third transmit events and for transmitting broadband focused wave energy encoded with a second Golay code of said Golay code pair during second and fourth transmit events for each of a multiplicity of transmit focal positions in each of a multiplicity of scan planes;

a receiver for forming first through fourth receive signals from said first through fourth transmit events, respectively, for each of a multiplicity of scan lines in each of said scan planes;

a filter for forming a flow signal from said first through fourth receive signals for each of said scan lines in each of said scan planes;

a computer for generating imaging data representing a three-dimensional projection of a set of flow signals forming a data volume; and

a display for displaying an image which is a function of said three-dimensional projection.

39. A method for three-dimensional imaging of stationary and moving reflectors in a body, comprising the steps of:

transmitting at least two broadband encoded focused beams of wave energy for each of a multiplicity of transmit focal positions in each of a multiplicity of scan planes intersecting the body;

generating echo signals derived from echoes of wave energy returned from the body following each transmission of a focused beam for each of a multiplicity of scan lines in each of said scan planes;

forming a B-mode flow signal component and a B-mode signal component indicative of moving reflectors and stationary reflectors, respectively, for each of said scan lines in each of said scan planes based on said echo signals;

generating imaging data representing a three-dimensional projection of a data volume formed from said B-mode flow and B-mode signal components; and

displaying a three-dimensional image of stationary and moving reflectors as a function of said three-dimensional projection.

40. A method of operating an imaging system, comprising the steps of:

(a) transmitting encoded focused wave energy during first through N-th transmit events for each of a multiplicity of transmit focal positions in each of a multiplicity of scan planes;

(b) forming first through N-th receive signals from said first through N-th transmit events for each of a multiplicity of scan lines in each of said scan planes;

(c) filtering said first through N-th receive signals based on a weighting sum to form a respective flow signal for each scan line in each of said scan planes;

(d) generating imaging data representing a three-dimensional projection of a data volume defined by the respective flow signals; and

(e) displaying an image as a function of said three-dimensional projection.