Noninvasive continuous cardiac output monitor

• US 6,186,955 B1
• Filed: 11/16/1998
• Issued: 02/13/2001
• Est. Priority Date: 11/16/1998
• Status: Expired due to Fees

• Current Assignee: Gail D. Baura
• Original Assignee: Gail D. Baura
• Inventors: Baura, Gail D.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US09/192,944
• Time in Patent Office: 820 Days
• Field of Search: 600/526, 600/547, 128/924, 128/925
• US Class Current: 600/526
• CPC Class Codes: A61B 5/028 by thermo-dilution
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients

Abstract

Method and apparatus for continuous, non-invasive determination of cardiac output which processes a sequence of non-invasive cardiography signals which are quantitatively dependent upon cardiac output within a computer system and associated neural network capable of generating a single output signal for the combined input signals, wherein the neural network applies weighting factors determined during a training phase to force the output signal to match the known value of cardiac output determined by invasive means and reports the single output signal as the determined value of cardiac output.

Claims

1. A method for noninvasive, continuous determination of cardiac output comprising:

(a) generating a sequence of noninvasive cardiography signals which are quantitatively dependent upon cardiac output;

(b) transmitting said sequence of noninvasive cardiography signals to a computer system and associated neural network programmed to be capable of generating a single output signal from the combined sequence of signals;

(c) processing said sequence of signals according to the programming incorporated in said computer system and associated neural network by;

(i) applying previously-determined weighting factors incorporated in said neural network to said sequence of signals, which weighting factors cause the output signal of the neural network to match the value of cardiac output determined, by invasive cardiography signals, to correspond to said sequence of noninvasive cardiography signals; and

(d) reporting said single output signal as the determined value of cardiac output corresponding to said sequence of noninvasive cardiography signals.

2. The method for determination of cardiac output as recited in claim 1 wherein said previously-determined weighting factors incorporated in said neural network are determined during a training phase which utilizes concurrent invasive and noninvasive patient cardiac output data.

3. The method for determination of cardiac output as recited in claim 1 wherein said sequence of noninvasive cardiography signals are generated by impedance cardiography.

4. A method for noninvasive, continuous determination of cardiac output as recited in claim 1 wherein the known value of cardiac output is determined by an indicator-dilution technique.

5. A method for noninvasive, continuous determination of cardiac output as recited in claim 4 wherein the known value of cardiac output is determined by thermodilution.

6. A method for noninvasive, continuous determination of cardiac output as recited in claim 1 wherein the sequence of non-invasive cardiography signals are generated by a partial carbon dioxide rebreathing technique.

7. A method for noninvasive, continuous determination of cardiac output as recited in claim 1 wherein the sequence of non-invasive cardiography signals are generated by an echo-doppler technique.