Bioactive coating for vaso-occlusive devices
First Claim
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1. A vaso-occlusive device comprising:
- a) a vaso-occlusive member;
b) an adhesive inner coating on at least a portion of said vaso-occlusive member; and
c) a protein-based outer coating on said inner coating.
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Abstract
This is a medical device for forming an embolism within the vasculature of a patient. More particularly, it is a vaso-occlusion device at least partially coated with a bioactive agent, a collagenous material, or a collagenous coating optionally containing or coated with other bioactive agents. A coated vaso-occlusive device which is highly flexible is also a variation.
137 Citations
42 Claims
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1. A vaso-occlusive device comprising:
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a) a vaso-occlusive member;
b) an adhesive inner coating on at least a portion of said vaso-occlusive member; and
c) a protein-based outer coating on said inner coating. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A vaso-occlusive device comprising:
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a) a vaso-occlusive member, b) a protein-based outer coating on said vaso-occlusive member; and
c) an adhesive material located between at least a portion of said outer coating and at least a portion of said vaso-occlusive member. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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24. A vaso-occlusive device comprising:
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a) a vaso-occlusive member having a flexibility;
b) a protein-based outer coating on said vaso-occlusive member in such amount and thickness that the flexibility of the vaso-occlusive device is not more than 35% stiffer than said vaso-occlusive member; and
c) an adhesive material located between at least a portion of said outer coating and at least a portion of said vaso-occlusive member. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 39, 40, 41)
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35. A vaso-occlusive device comprising:
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a) a vaso-occlusive member;
b) an adhesive inner tie layer on at least a portion of said vaso-occlusive member; and
c) a bioactive-material-based outer coating on said inner tie layer. - View Dependent Claims (36, 37, 38, 42)
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Specification